Osteointegration of Autogenous Bone Graft Associated With Osteoblastic Cells Under Treatment With Caffeine

Abstract

It was concluded that the association of AB from calvaria + OC demonstrated progressive osteointegration and accelerated the repair of bone defects in animals treated with daily caffeine.

Effects of Coffee Intake and Intraperitoneal Caffeine on Bone Repair Process - A Histologic and Histometric Study

“…The results of the present study confirm those of Lacerda et al (6), who observed a lower percentage of alveolar bone after tooth extraction associated with daily ingestion of coffee, and Macedo et al (9), who reported a delay in bone formation with the use of autogenous bone as graft material. It also corroborates the findings of another study (10) in which caffeine injected intraperitoneally was able to potentialize the disturbances of bone metabolism caused by induced osteoporosis in rats.…”

“…Studies have suggested that caffeine, a major constituent of coffee, is associated with a significantly increased risk of fractures, osteoporosis, periodontal disease and poor osseointegration of bone grafts (8,9,12). …”

“…While some studies have suggested that the effects of coffee/caffeine on bone metabolism are still controversial (6), others have reported that caffeine, a major constituent of coffee, is associated with a significant increase of periodontal diseases (7), fracture of osteoporotic bones (8), increase in urinary calcium and decrease of bone mineral density (6), as well as delay in bone repair process (9). Also, caffeine has an additional deleterious effect when administrated to animals with osteoporotic bones (10).…”

Effects of Caffeine on Bones of Osteoporotic Rats

“…13,14 Regarding the process of bone repair caused by tooth extraction, daily administration of caffeine causes a decrease in bone mineral density and in the percentage of the newly formed bone, resulting in the delay of the whole healing process. 9,10,15 Considering that caffeine is widely consumed and the number of patients with postmenopausal osteoporosis requiring surgical procedures involving bone tissue, such as dental extraction, grafts for bone reconstruction and even the installation of osseointegrated implants is increasing, it is important to clarify the structural changes related to bone repair. Thus, the present study aimed to evaluate, histomorphometrically, the effect of estrogen deficiency caused by ovariectomy in bone defects repair created by tooth extraction in rats subjected to daily treatment with caffeine.…”

“…2,3,7,8 An interesting model for the study of bone dynamics is the alveolar healing process, and this process after tooth extraction in experimental animals has been the subject of several studies, so that its sequence of events is relatively well known. 6,9,10 Several endogenous and exogenous factors control the formation, absorption, and remodeling of bone tissue, 11 among them the daily intake of caffeine stands out. Caffeine is a methyl xanthine found in many drinks, food, medications, and dietary supplements, and it is consumed by the great majority of the world population.…”