Osteomielitis crónica por Corynebacterium striatum en una adolescente

Beltrán-Arroyave, Claudia Patricia; Díaz-Díaz, Alejandro; Loaiza-Díaz, Natalia

doi:10.4067/s0716-10182016000600014

Cited by 9 publications

(3 citation statements)

References 9 publications

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“…intravenous catheter-related bloodstream infections, endocarditis, postsurgical infections, urinary tract infections, and peritoneal dialysis-related peritonitis (4)(5)(6)(7)(8)(9)(10)(11)(12). The spectrum of Corynebacterium sp.…”

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confidence: 99%

Corynebacterium Species Rarely Cause Orthopedic Infections

et al. 2018

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Corynebacteriumspp. are rarely considered pathogens, but data onCorynebacteriumspp. as a cause of orthopedic infections are sparse. Therefore, we asked how oftenCorynebacteriumspp. caused an infection in a defined cohort of orthopedic patients with a positive culture. In addition, we aimed to determine the species variety and the susceptibility of isolated strains to define potential treatment strategies. We retrospectively assessed all bone and joint samples that were collected between 2006 and 2015 from an orthopedic ward and that were positive forCorynebacteriumspp. by culture. The isolates were considered relevant to an infection if the sameCorynebacteriumsp. was present in at least two samples. We found 97 orthopedic cases with isolation ofCorynebacteriumspp. (128 positive samples). These were mainlyCorynebacterium tuberculostearicum(n= 26),Corynebacterium amycolatum(n= 17),Corynebacterium striatum(n= 13), andCorynebacterium afermentans(n= 11). Compared to the species found in a cohort of patients with positive blood cultures hospitalized in nonorthopedic wards, we found significantly moreC. striatum- andC. tuberculostearicum-positive cases but noC. jeikeium-positive cases in our orthopedic cohort. Only 16 out of 66 cases (24.2%) with an available diagnostic set of at least two samples had an infection. Antibiotic susceptibility testing (AST) showed various susceptibility results for all antibiotics except vancomycin and linezolid, to which 100% of the isolates were susceptible. The rates of susceptibility of corynebacteria isolated from orthopedic samples and of isolates from blood cultures were comparable. In conclusion, our study results confirmed that aCorynebacteriumsp. is most often isolated as a contaminant in a cohort of orthopedic patients. AST is necessary to define the optimal treatment in orthopedic infections.

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confidence: 99%

Corynebacterium Species Rarely Cause Orthopedic Infections

et al. 2018

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“…Corynebacterium striatum and P mirabilis , bacteria also identified in several samples analyzed in this study, have clinical relevance because strains resistant to several antibiotics have been frequently reported 35,36 …”

Section: Discussionmentioning

confidence: 76%

“…34 Corynebacterium striatum and P mirabilis, bacteria also identified in several samples analyzed in this study, have clinical relevance because strains resistant to several antibiotics have been frequently reported. 35,36 As for the CFU count, the most frequent values were between 10,000 and 100,000 in aerobiosis and between 1,000 and 10,000 in anaerobiosis. A study by Ferreira et al 37 with chronic wounds suggests that an infection may be present when there is a high microbial load: among the wounds analyzed, those with signs of infection were those with values greater than 10 5 CFUs/mL.…”

Section: Discussionmentioning

confidence: 98%

Does pH Influence the Bacterial Profile of Chronic Lesions? An Analysis of Venous Ulcer Samples

Sergio

Santos²,

Silveira³

et al. 2022

Adv Skin Wound Care

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OBJECTIVE To analyze the pH of venous ulcers and their relationship with the quantitative and qualitative bacterial profile of the wounds. METHODS Cross-sectional study carried out through data collection and microbiologic analyses of samples obtained from 35 venous ulcers. Investigators performed pH measurement with indicator strips and collected biologic material using swabs. After aerobic and anaerobic cultivation, colony-forming units (CFUs) were counted and used for bacterial identification via mass spectrometry. RESULTS The pH values ranged from 7.9 to 8.7; 8.5 (37.1%) was the most frequent, followed by 8.3 (28.6%). The most common species were Staphylococcus aureus (68.6%), Pseudomonas aeruginosa (62.9%), Proteus mirabilis (45.7%), and Corynebacterium striatum (40.0%). The number of CFUs ranged from 0 to 200,000 in both anaerobiosis and aerobiosis and was predominantly between 1,000 and 10,000 (37.1%) in anaerobiosis and between 10,000 and 100,000 (37.1%) in aerobiosis. No association was found between the different pH values and the variation in CFUs in anaerobiosis (P = .21) and aerobiosis (P = .55) or by bacterial species identified: S aureus (P = .41), P aeruginosa (P = .29), P mirabilis (P = .19), and C striatum (P = .96). CONCLUSIONS The pH of venous ulcers did not influence bacterial profile in quantitative or qualitative parameters.

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Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020

et al. 2021

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Corynebacterium striatum is part of microbiota of skin and nasal mucosa of humans and has been increasingly reported as the etiologic agent of community-acquired and nosocomial diseases. Antimicrobial multidrug-resistant (MDR) C. striatum strains have been increasingly related to various nosocomial diseases and/or outbreaks worldwide, including fatal invasive infections in immunosuppressed and immunocompetent patients. Although cases of infections by C. striatum still neglected in some countries, the improvement of microbiological techniques and studies led to the increase of survival of patients with C. striatum nosocomial infections at different levels of magnitude. Biofilm formation on abiotic surfaces contributes for the persistence of virulent C. striatum and dissemination of antimicrobial resistance in hospital environment. Besides that, empirical antibiotic therapy can select multi-resistant strains and transfer intra and interspecies genes horizontally. In this study, a worldwide survey of C. striatum human infections and nosocomial outbreaks was accomplished by the analysis of clinical–epidemiological and microbiological features of reported cases from varied countries, during a 44-year period (1976–2020).

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Osteomielitis crónica por Corynebacterium striatum en una adolescente

Cited by 9 publications

References 9 publications

Corynebacterium Species Rarely Cause Orthopedic Infections

Corynebacterium Species Rarely Cause Orthopedic Infections

Does pH Influence the Bacterial Profile of Chronic Lesions? An Analysis of Venous Ulcer Samples

Worldwide survey of Corynebacterium striatum increasingly associated with human invasive infections, nosocomial outbreak, and antimicrobial multidrug-resistance, 1976–2020

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