2020
DOI: 10.1016/j.bjoms.2019.09.023
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Osteonecrosis and osteomyelitis of the jaw associated with tumour necrosis factor-alpha (TNF-α) inhibitors: a systematic review

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Cited by 39 publications
(30 citation statements)
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“…As mentioned above, IV and oral bisphosphonates and denosumab are undoubtedly risk factors for developing MRONJ [1,2,9,29,30]. Moreover, angiogenesis inhibitors, tyrosine kinase inhibitors, monoclonal antibodies, mTOR inhibitors, and immunosuppressants have been reported as possible risk factors for the development of MRONJ [7,16,17,24] (Table 4).…”
Section: Risk Factors For Mronjmentioning
confidence: 95%
See 1 more Smart Citation
“…As mentioned above, IV and oral bisphosphonates and denosumab are undoubtedly risk factors for developing MRONJ [1,2,9,29,30]. Moreover, angiogenesis inhibitors, tyrosine kinase inhibitors, monoclonal antibodies, mTOR inhibitors, and immunosuppressants have been reported as possible risk factors for the development of MRONJ [7,16,17,24] (Table 4).…”
Section: Risk Factors For Mronjmentioning
confidence: 95%
“…Epidemiology of MRONJbeen reported to possibly induce MRONJ, as well as denosumab and bevacizumab. Two cases by rituximab[22,23], 4 cases by adalimumab and infliximab, which are monoclonal TNF-α antibodies[24], and 2 cases by romosozumab, which is a human monoclonal sclerostin antibody[25], have been reported to possibly cause MRONJ. mTOR inhibitors (everolimus and temsirolimus) and immunosuppressants (methotrexate and corticosteroids) may also cause MRONJ.…”
mentioning
confidence: 99%
“…However, anti-TNF-α therapy is associated with adverse events related to systemic exposure. These adverse events include infusion reactions [ 25 , 26 ], psoriasis or psoriasiform lesions [ 27 ], osteonecrosis of the jaw [ 28 , 29 ], the development of antinuclear antibodies (ANA) [ 30 , 31 , 32 , 33 ] and an increased risk of opportunistic infections [ 34 , 35 , 36 ] and developing lymphoma [ 37 ]. Additionally, infusion reactions are associated with therapy discontinuation [ 38 ].…”
Section: Introductionmentioning
confidence: 99%
“…15,64 Other drugs also have the potential to cause ONJ. 65,66 Currently, no systematic analysis has been performed to link the usage of recreational drugs to ONJ. This systematic review has highlighted the potential relationship between several types of illicit drugs with this severe condition.…”
Section: Discussionmentioning
confidence: 99%