Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment

Hines, Jeremy T.; Jo, Woo-Lam; Cui, Quanjun; Mont, Michael A.; Koo, Kyung Hoi; Cheng, Edward Y.; Goodman, Stuart B.; Ha, Yong Chan; Hernigou, P; Jones, Lynne C.; Kim, Shin‐Yoon; Sakai, Takashi; Sugano, Nobuhiko; Yamamoto, Takuaki; Lee, Mel S.; Zhao, Dewei; Drescher, Wolf; Kim, Tae Young; Lee, Yong Seuk; Yoon, Byung‐Ho; Baek, Seung‐Hoon; Ando, Wataru; Kim, Hong Seok; Park, Jung-Wee

doi:10.3346/jkms.2021.36.e177

Cited by 117 publications

(66 citation statements)

References 111 publications

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“…Tracing the history of ONFH, research of its pathogenesis has been ongoing since the disease was described by Jean Cruveilhier, a French anatomist and pathologist but keeps incompletely understood ( Dubois and Cozen, 1960 ). However, there is one agreement that local ischemia due to compromised blood flow is the final common pathway in the pathogenesis of ONFH ( Hines et al, 2021 ). Most well-known risk factors and associated conditions of ONFH eventually leads to a kind of intra-osseous compartment syndrome inside the femoral head due to an ischemic cascade: 1 ) overgrowth of marrow adipocyte 2 ) intra-osseous hypertension; 3 ) vascular compression and intravascular hypercoagulability; 4 ) bone marrow necrosis and osteocyte death and 5 ) fibrovascular reparation around the necrotic zone ( Yoon et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

“…Osteonecrosis of femoral head (ONFH) is a progressive hip joint disorder without consensus of effective treatment, ultimately leading to total hip replacement ( Mont et al, 2006 ). The pathogenesis of ONFH is perplexing and needs further investigation ( Hines et al, 2021 ). Use of steroid, overuse of alcohol and trauma of femoral neck or head are the three well known risk factors for ONFH.…”

Section: Introductionmentioning

confidence: 99%

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Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

Peng

Wang

et al. 2021

Front. Pharmacol.

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Osteonecrosis of femoral head (ONFH) is a progressive hip joint disease without disease-modifying treatment. Lacking understanding of the pathophysiological process of ONFH has become the humper to develop therapeutic approach. Serum amyloid A (SAA) is an acute phase lipophilic protein during inflammation and we found that SAA is increased for the first time in the serum of ONFH patients through proteomic studies and quantitatively verified by ELISA. Treating rBMSCs with SAA inhibited the osteogenic differentiation via Wnt/β-catenin signaling pathway deactivation and enhanced the adipogenic differentiation via MAPK/PPARγ signaling pathway activation. Finally, bilateral critical-sized calvarial-defect rat model which received SAA treated rBMSCs demonstrated reduction of bone formation when compared to untreated rBMSCs implantation control. Hence, SAA is a vital protein in the physiological process of ONFH and can act as a potential therapeutic target to treat ONFH.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

Peng

Wang

et al. 2021

Front. Pharmacol.

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“…Osteonecrosis is a disease caused by the destruction of blood supply and decreased skeletal cell activity (Guo et al, 2014;Cui et al, 2021;Hines et al, 2021). The reconstruction of bone and blood supply in the necrotic area is the top priority in treating osteonecrosis (Zhu et al, 2020).…”

Section: Functionalized Polymer Materials In Osteonecrosis Therapymentioning

confidence: 99%

“…Osteonecrosis is a disease caused by a temporary or permanent loss of blood supply to the bone. The causes of osteonecrosis are extensive, and the pathogenesis is still unclear (Guo et al, 2014;Cui et al, 2021;Hines et al, 2021). The potential pathogenic factors that have been explored include trauma (Pascarella et al, 2019), long-term history of heavy drinking (Chen et al, 2017), hyperlipidemia (Mogensen et al, 2017), history of hormone medication (Li et al, 2018b), decompression sickness (Jones et al, 1993), and blood system diseases such as Gaucher disease (Reed et al, 2018) and sickle cell anemia (Severyns and Gayet, 2021) among others.…”

Section: Introductionmentioning

confidence: 99%

Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Dong

Zhu

Zhang

et al. 2021

Front. Bioeng. Biotechnol.

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Osteonecrosis without effective early treatment eventually leads to the collapse of the articular surface and causes arthritis. For the early stages of osteonecrosis, core decompression combined with bone grafting, is a procedure worthy of attention and clinical trial. And the study of bone graft substitutes has become a hot topic in the area of osteonecrosis research. In recent years, polymers have received more attention than other materials due to their excellent performance. However, because of the harsh microenvironment in osteonecrosis, pure polymers may not meet the stringent requirements of osteonecrosis research. The combined application of polymers and various other substances makes up for the shortcomings of polymers, and to meet a broad range of requirements for application in osteonecrosis therapy. This review focuses on various applying polymers in osteonecrosis therapy, then discusses the development of biofunctionalized composite polymers based on the polymers combined with different bioactive substances. At the end, we discuss their prospects for translation to clinical practice.

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“…Local ischemia due to compromised blood flow is the final common pathway in the pathogenesis of ON. Ischemic lesions do not always lead to irreversible bone necrosis if there is a restoration of vascular perfusion 5 . Glucocorticoid is one of the most known involved factors for ON, particularly dexamethasone, by a kind of intraosseous compartment syndrome starting with an hyperplasia of marrow fat cell to intra-osseous hypertension causing an impaired blood flow 6,7 .…”

Section: Introductionmentioning

confidence: 99%

Symptomatic osteonecrosis in French survivors of Childhood and Adolescent Leukemia: a clinical and radiological study from the L.E.A. program

HUAULT

Gautier

Charon

et al. 2022

Preprint

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Background. Osteonecrosis (ON) is a long-known complication of acute leukemia (AL) management affecting 1 to 10% of young patients, leading to long-term morbidity. Widespread access to Magnetic Resonance Imagery (MRI) over the past ten years has allowed earlier detection and more accurate assessment. This study investigated clinical and radiological features of ON, among the large French cohort L.E.A (Leucémie Enfant Adolescent) Procedure. Patients with ON were retrospectively enrolled and risk factors for the onset, the multifocal involvement and severe damage were analyzed. Quality of life (QoL) was also evaluated. A sub-study described radiological features. Results. 129/4973 patients developed ON (2.5%) and were preferentially aged over 10 years at time of AL diagnosis (OR 22.46, p <10-6). Females were preferentially affected (OR 1.8, p=0.002) like patients treated for relapse (OR 1.81, p=0.041). Patients presenting ON suffered more frequently from other sequelae (p<10-6). Most of the necrosis were involving weight-bearing joints and multiple joints in 69% of cases. MRI of 39 patients with ON were double blinded reviewed. Overall, 14/39 suffered from severe impairment, preferentially on hips. QoL of adolescents and adults was poor and permanently affected once ON occurred. Conclusions. Age of over 10 years at diagnosis of AL, relapse and female sex were at risk of developing ON involving preferentially multiple joints. One third was severe and lasting poor QoL impacting several domains was found. Future studies should include prospective data on management and biological genetic features to build a targeted screening program to detect and manage ON earlier.

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Osteonecrosis of the Femoral Head: an Updated Review of ARCO on Pathogenesis, Staging and Treatment

Cited by 117 publications

References 111 publications

Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

Serum Amyloid A Correlates With the Osteonecrosis of Femoral Head by Affecting Bone Metabolism

Polymer Scaffolds-Enhanced Bone Regeneration in Osteonecrosis Therapy

Symptomatic osteonecrosis in French survivors of Childhood and Adolescent Leukemia: a clinical and radiological study from the L.E.A. program

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