Osteopetrosis: A rare cause of anemia - Review of literature

Saluja, Sumita; Bhandari, Sudip; Aggarwal, Seema; Kapoor, Sujala

doi:10.4103/0377-4929.54995

Cited by 6 publications

(8 citation statements)

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“…A decrease in the number of red blood cells may result in an anemia disorder. Previous literature showed a positive correlation between osteopetrosis and anemia disorder (Fischer et al, 1991;Gamsu et al, 1961;Lees and Sautter, 1979;Saluja et al, 2009;Sreehari et al, 2011). Our quantitative study of abnormal aging mice suggests that the anemia disorder may be directly linked to the internal expansion of cortical bones at diaphysis.…”

Section: Discussionmentioning

confidence: 46%

X-ray imaging characterization of femoral bones in aging mice with osteopetrotic disorder

Huang

Chang

2015

Micron

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Section: Discussionmentioning

confidence: 46%

X-ray imaging characterization of femoral bones in aging mice with osteopetrotic disorder

Huang

Chang

2015

Micron

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“…Cranial CT and MRI are additional investigations to rule out intracranial complications like cranial nerve palsies, ventriculomegaly, atrophy, tonsillar herniation, vertebral artery compression, etc., which are attributable to the skull base sclerosis. [45] Cranial CT did not reveal hydrocephalus, foraminal compression, or any other abnormalities in our infant.…”

Section: Discussionmentioning

confidence: 65%

“…AD variety also known as benign or tarda variety is detected in older children, adolescents, and adults and has a relatively benign course. [ 5 ] Infantile OP manifests in the first few months of life, usually with features of severe bone marrow failure. Clinical presentation includes hepatosplenomegaly and failure to thrive, while hematological manifestations are anemia and thrombocytopenia.…”

Section: Discussionmentioning

confidence: 99%

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Imaging Diagnosis of Neonatal Anemia: Report of Two Unusual Etiologies

Grover

Preethi

Saluja

et al. 2013

Journal of Clinical Imaging Science

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Anemia in neonatal period is rare, with the common causes being Rh and ABO blood group incompatibility, hemorrhagic disease of newborn, congenital hemolytic anemia, hemoglobinopathies, and TORCH (toxoplasmosis, rubella, cytomegalovirus, herpes virus) infections. Congenital leukemia and infantile osteopetrosis (OP) are among the rare causes of neonatal anemia. A review of the literature shows approximately 200 reported cases of congenital leukemia. Articles describing the imaging features of congenital leukemia are still rarer. Infantile OP, another rare disorder with a reported incidence of 1 in 250,000 has characteristic imaging features, which are diagnostic of the disease. We report a case each, of two rare diseases: Congenital leukemia and infantile osteopetrosis. Additionally, our report highlights the radiological and imaging features of congenital leukemia and infantile OP and their crucial role in arriving at an early diagnosis.

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“…Bone heterogeneity is an essential quantity and is affected by the composition of different bone tissues. In particular, bone composition and therefore bone heterogeneity may be affected by the process of bone turn over, bone matrix dynamics, and bone development kinetics 13–15,42 . Therefore, the Nakagami parameter is a potentially useful quantity to evaluate different aspects of bone characteristics.…”

Section: Resultsmentioning

confidence: 99%

Extraction of gray-scale intensity distributions from micro computed tomography imaging for femoral cortical bone differentiation between low-magnesium and normal diets in a laboratory mouse model

Wang

Cheng

et al. 2019

Sci Rep

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Previous studies have shown that the geometric development of femoral trabecular bone is affected by insufficient dietary intake of magnesium. However, it is not clear whether the development of femoral cortical bone can be quantitatively evaluated according to a diet with inadequate magnesium supplementation. Therefore, we used a micro computed tomography (CT) imaging approach with a laboratory mouse model to explore the potential application of texture analysis for the quantitative assessment of femoral cortical bones. C57BL/6J male mice were divided into two groups, where one group was fed a normal diet and the other group was fed a low-magnesium diet. We used a micro CT scanner for image acquisition, and the subsequent development of cortical bone was examined by texture analysis based on the statistical distribution of gray-scale intensities in which seven essential parameters were extracted from the micro CT images. Our calculations showed that the mean intensity increased by 7.20% ( p = 0.000134), sigma decreased by 29.18% ( p = 1.98E-12), skewness decreased by 19.52% ( p = 0.0000205), kurtosis increased by 9.62% ( p = 0.0877), energy increased by 24.19% ( p = 3.32E-09), entropy decreased by 6.14% ( p = 3.00E-10), and the Nakagami parameter increased by 104.32% ( p = 4.13E-12) in the low-magnesium group when compared to the normal group. We found that the statistical parameters extracted from the gray-scale intensity distribution were able to differentiate between femoral cortical bone developments in the two different diet groups.

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Osteopetrosis: A rare cause of anemia - Review of literature

Cited by 6 publications

References 0 publications

X-ray imaging characterization of femoral bones in aging mice with osteopetrotic disorder

X-ray imaging characterization of femoral bones in aging mice with osteopetrotic disorder

Imaging Diagnosis of Neonatal Anemia: Report of Two Unusual Etiologies

Extraction of gray-scale intensity distributions from micro computed tomography imaging for femoral cortical bone differentiation between low-magnesium and normal diets in a laboratory mouse model

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