Osteopetrosis complicated by osteomyelitis of the maxilla: A rare case report and review of the literature

Sallies, Moegamat; Titinchi, Fadi; Morkel, Jean

doi:10.17219/dmp/119998

Cited by 9 publications

(6 citation statements)

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“…However, the realization is difficult in the setting of OP. As a result, complications such as hardware failure, osteomyelitis, prosthetic fractures, and pseudarthrosis are common [18,19]. Results of both conservative as well as surgical treatment were reported with mixed results [20,21].…”

Section: Autosomal Dominant Osteopetrosis Aromentioning

confidence: 99%

Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis

et al. 2022

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Treatment of femoral neck fractures secondary to osteopetrosis is an uncertain and puzzled decision. Experience in the treatment, especially in the pediatric population, is scarcely reported. The duration of conservative treatment is prolonged and poses the risks of non-union and development of coxa vara deformity. The recommended treatment is closed reduction and internal fixation; however, surgery on osteopetrotic bone is challenging due to defective bone marrow function, delayed consolidation and higher risk of intraoperative fractures. Slipped capital femoral epiphysis secondary to osteopetrosis is very rarely reported. This article presents the case of a 5-year-old female patient with rapidly deteriorating physical function due to bilateral proximal femoral Salter-Harris type II fractures with associated slippage of the growth plates secondary to confirmed autosomal recessive osteopetrosis. Operative treatment was performed in a tertiary level orthopedic center with closed reduction and internal fixation with cannulated screws. A loss of fixation with coxa vara deformity was seen on the left side 7 months postoperatively with increasing pain. A revision surgery with reosteosynthesis and a valgus osteotomy was thus performed which showed good subjective and objective results 1 year postoperatively with complete bony union.

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Section: Autosomal Dominant Osteopetrosis Aromentioning

confidence: 99%

Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis

et al. 2022

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“…In the literature, the treatment method commonly uses the antibiotic therapy for jaw osteomyelitis in the patients with osteopetrosis. 3,14,15 In conclusion, the case report presents the clinical and radiographic features of osteomyelitis occurring in the fracture line after the tooth extraction in the mandible of the patient with osteopetrosis. Tooth extraction should be limited in patients with osteopetrosis because the extraction can be inducing the complications such as jaw fracture and osteomyelitis.…”

Section: Discussionmentioning

confidence: 95%

Osteomyelitis Developing in Fracture After Tooth Extraction in the Mandible of Patient with Osteopetrosis

BAĞCI,

ÜÇOK

2023

Turkiye Klinikleri J Dental Sci

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Osteopetrosis is a hereditary disease characterized by increased bone density due to a defect in osteoclast function and malformed bone resorption. 1 Osteopetrosis was originally described in 1904 by the German radiologist Albers-Schönberg. 2 Three types of osteopetrosis have been classified as the malign autosomal recessive type, the intermediate autosomal recessive, and the benign autosomal dominant type. 3 There are crucial clinical and radiological findings in the diagnosis of the osteopetrosis. 1 The clinical findings are commonly skeletal abnormalities such as fragile bone and osteosclerosis and hematologic diseases such as anemia or thrombocytopenia.In addition, vision defect and hearing impairment may occur in the patients. The radiological findings are generally diffuse osteosclerosis, increased cortical bone thickness, and decreased medullary canal diameter. 3 A "marble bone" appearance is usually common in the skeleton, a "bone-in-bone" appearance in the bones of the spine or the hand phalanges, and a "rugger-jersey spine" appearance in the vertebral endplates. 1 Orofacial examination findings of patients with the osteopetrosis are generally unerupted tooth, malformed crowns and roots, enamel hypoplasia, increased dental caries, and tooth loss. 3,4 Furthermore,

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“…Osteomyelitis primarily affects the mandible and rarely affects the maxilla because the maxilla has a thinner cortical bone and contains numerous collateral blood vessels [ 5 ]. In total, 24 cases of maxillary osteomyelitis complicated by osteopetrosis have been reported from 1971 to 2020 [ 6 ], but there were no reports from journals in the ophthalmology field. The age ranged from 8 to 66, and this case was the oldest at 76 years old compared to previous reports.…”

Section: Discussionmentioning

confidence: 99%

A Case of Osteopetrosis with Orbital Inflammation Secondary to Maxillary Osteomyelitis

Misaki,

Murao,

Shinomiya

et al. 2024

Case Rep Ophthalmol

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Introduction: Osteopetrosis is a rare heritable disorder characterized by increased bone density resulting from osteoclast dysfunction. Major complications include bone fracture, osteomyelitis, anemia, and cranial nerve compression. Optic atrophy can occur due to compression of the optic nerve. Although osteomyelitis of the jaw is a common complication, it rarely occurs in the maxilla. Here, we report a case of a 74-year-old female with osteopetrosis who developed maxillary osteomyelitis, leading to orbital inflammation. Case Presentation: She was referred to our clinic for 2 months of ptosis and swelling of the left eyelid and temporal region. Previous imaging revealed a left intraorbital occupying lesion, but a biopsy of the temporal subcutaneous tissue did not provide a definitive diagnosis. After 7 months, she presented with severe temporal swelling and purulent discharge. Upon examination, maxillary osteomyelitis resulting from caries of the upper jaw was observed. Treatment with oral antibiotics, drainage of the temporal skin fistula, and regular cleaning of the maxillary drainage improved her symptoms. Conclusion: This is a rare case of maxillary osteomyelitis associated with osteopetrosis, causing orbital inflammation.

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Osteopetrosis complicated by osteomyelitis of the maxilla: A rare case report and review of the literature

Cited by 9 publications

References 0 publications

Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis

Pediatric patient with a bilateral Salter-Harris II fracture and slipped capital femoral epiphysis secondary to autosomal recessive osteopetrosis

Osteomyelitis Developing in Fracture After Tooth Extraction in the Mandible of Patient with Osteopetrosis

A Case of Osteopetrosis with Orbital Inflammation Secondary to Maxillary Osteomyelitis

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