Osteopontin attenuates aging‐associated phenotypes of hematopoietic stem cells

Abstract

We have found that panel A in Figure 5 (subpanel Old + C) is mistakenly a duplication of panel H in Figure 4 (subpanel Old + FL). According to our inspection of the original data sets, this is due to a mistake during the assembly of the panels. We show here the amended correct images for Figure 5, panel A (Old + C).The change does not affect the original conclusions presented. We apologize for this mistake. All authors approve of this correction. Old + Thr

Hematopoietic Stem Cell Dynamics Are Regulated by Progenitor Demand: Lessons from a Quantitative Modeling Approach

“…In summary, the model predicts that an aged hematopoietic system reacts robustly to major challenges and preserves the general dynamics observed for the young situations in Figure 2 with a tendency of enhanced expansion of rpHSCs. These findings are in qualitative agreement with several experimental studies on transplantation of aged mice, which report multiclonal system repopulation on similar time scales compared with young recipients [60][61][62]. However, we wish to point out that those irradiation-based assays are not fully comparable to our simplifying model assumption, which does not recapitulate the effect of a damaged hematopoietic microenvironment.…”

Endothelial transplantation rejuvenates aged hematopoietic stem cell function

“…Within the BM hematopoietic microenvironment, the vascular endothelium is indispensable for supporting HSC quiescence, self-renewal, and differentiation into lineage-committed progeny (19)(20)(21)(22)(23)(24)(25). The aged BM microenvironment has also been shown to influence hematopoietic aging in young HSCs (26)(27)(28)(29)(30). While ECs are a critical component of the HSC niche (19,20,23), the individual role of aged ECs in the process of hematopoietic aging has not been examined (27).…”

HSC Niche Biology and HSC Expansion Ex Vivo

“…The underlying assumption has been that proximity serves as a surrogate marker for the relative importance of the regulatory influence of particular types of stromal cells on HSCs [12, 16, 21, 33, 34, 38, 39]. However, there are also multiple examples in which cells that are, on average, relatively distant from HSCs within the BM influence HSCs, such as osteoblasts [43]. Osteoblasts have been reported to enable a 3–4 fold expansion of human long-term culture-initiating cells (LTC-ICs) in vitro [44, 45], suggesting that stem cell self-renewal can be supported by osteoblast-derived factors.…”