Osteopontin Combined With CD44v6, a Novel Prognostic Biomarker in Non-Small Cell Lung Cancer Undergoing Curative Resection

Receptor for hyaluronic acid-mediated motility (RHAMM, CD168) expression is prognostically important in both nodal negative and nodal positive large cell lung cancer

“…In this study, we could not reproduce the recently reported prognostic correlation of CD44v6 and OPN shown by Sun et al 11 One possible explanation is the different ratio of histological subtypes (ACA vs SCC) with more SCC in the study population of Sun et al and more ACA in our study group and the different ethnicity of the study collectives (Chinese patients in the study of Sun et al vs Middle European patients in our study). We found a negative correlation of CD44v6 and TTF1, indicating that expression of CD44v6 was less common in ACA, a fact that was also seen in the publication by Sun et al .…”

Immunohistochemical Expression and Serum Levels of CD44 as Prognostic Indicators in Patients with Non-Small Cell Lung Cancer

“…A multivariate analysis indicated that sCD44v6 level was an independent prognostic determinant for patients who underwent surgical resection for NSCLC. Although the multivariate analysis showed that there was no independent difference in immunochemical CD44v6 expression, a systematic review [14] , a meta-analysis [15] , and a recent report [33] support the finding that high CD44v6 expression is a prognostic factor for poor survival. In the present study of 261 patients, the multivariate analysis revealed that N factor and CD44v6 expression are independent prognostic factors (p = 0.0109 and 0.0485, respectively).…”

Osteopontin is a novel prognostic biomarker in early-stage non-small cell lung cancer after surgical resection

“…OPN may be one of important molecules to promote tumor progression, assess recurrence risk, and predict the prognosis of patients (Anborgh et al 2010;Johnston et al 2008). Recently, Sun et al (2013) reported that OPN was an independent and unfavorable predictor for OS and DFS in NSCLC. Their results agree with our own, and furthermore, our study documented that OPN expression was remarkably associated with increased risk of the recurrence after resection for early stage of NSCLC patients.…”