Osteopontin gene polymorphism in association with systemic lupus erythematosus in Chinese patients

Xu, Anping; Bai, Jie; Lü, Jun; Liang, Yan-yi; Li, Jingao; Lai, Deyuan; Wan, Xia; Huang, Hu-hui

doi:10.1097/00029330-200712010-00011

Cited by 32 publications

(24 citation statements)

References 20 publications

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“…These were the only two primarily associated OPN polymorphisms among 12 exonic and proximal promoter tested SNPs. The association with both promoter and 3= end OPN polymorphisms has been reported for SLE also in other populations [22,23].…”

Section: Discussionsupporting

confidence: 56%

“…Third, OPN might also be involved in the control of SSc fibrosis because of its key role in the synthesis and/or turnover of matrix components in both human and murine models [20,21]. Finally, polymorphisms in the OPN gene were reported to be associated with SLE [14,22,23]. Interestingly, it has been demonstrated that SLE-associated SNPs in OPN, similarly to those in IRF5 and PTPN22, predispose to a high serum IFN-␣ activity in SLE patients [24].…”

Section: Introductionmentioning

confidence: 99%

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Association of osteopontin regulatory polymorphisms with systemic sclerosis

et al. 2011

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Association of osteopontin regulatory polymorphisms with systemic sclerosis

et al. 2011

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“…Thus, nine articles met the inclusion criteria. [8][9][10][11][12][13][14][15][16] Three of the eligible studies contained data on two different groups, 9,12,13 which were treated independently. Thus, 12 comparisons were considered in the meta-analysis, which consisted of 1938 SLE patients and 3037 controls (Table 1).…”

Section: Studies Included In the Meta-analysismentioning

confidence: 99%

“…[8][9][10][11][12][13][14][15][16] Reasons for such disparity may be small sample size, low statistical power, and/or clinical heterogeneity. In order to overcome the limitations of individual studies and resolve inconsistencies, we performed this meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

Correlation between circulating osteopontin level in systemic lupus erythematosus and disease activity and associations between osteopontin polymorphisms and disease susceptibility: A meta-analysis

Lee

Song

2016

Lupus

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Objective This study aimed to systemically review the evidence regarding the relationship between circulating blood osteopontin (OPN) level and systemic lupus erythematosus (SLE), correlation between serum OPN levels and SLE activity, and association between OPN polymorphisms and SLE susceptibility. Methods We conducted a meta-analysis on the serum/plasma OPN levels in SLE patients and healthy controls, correlation coefficients between the circulating OPN level and SLE Disease Activity Index (SLEDAI) in SLE patients, and the association between OPN polymorphisms and SLE risk. Results Nine studies with 1938 SLE patients and 3037 controls were included. Meta-analysis revealed that, compared with the control group, the OPN level was significantly higher in the SLE group (SMD = 0.965, 95% CI = 0.337-1.393, p = 0.001) and in the SLE group with renal disease (SMD = 2.219, 95% CI = 0.681-3.757, p = 0.005). Meta-analysis of correlation coefficients showed a trend of positive correlation between the circulating OPN level and SLEDAI (correlation coefficient = 0.590, 95% CI = -0.025 to 0.881, p = 0.059). While no association was found between SLE and the OPN 707 T/C and 1083 G/A polymorphisms, a significant association was identified between the OPN 1239 C allele and SLE (OR = 1.192, 95% CI = 1.008-1.410, p = 0.040), and between the OPN 9250 C allele and SLE in Asians (OR = 2.070, 95% CI = 1.570-2.730, p = 2.5 × 10). Conclusions Our meta-analysis revealed a significantly higher circulating OPN level in SLE patients, a trend of positive correlation between OPN levels and SLE activity, and a significant association between OPN 1239 C/A and 9250 C/T polymorphisms, and SLE development.

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“…19,20 High circulating OPN levels have been reported and the presence of single nucleotide polymorphisms (SNPs) of the OPN gene have been explored in several inflammatory diseases, including multiple sclerosis, lupus erythematosus, and rheumatoid arthritis. [21][22][23][24][25] A recent study has shown that OPN e156G and 11239C in the 5 9 and 3 9 ends of the OPN gene may contribute to susceptibility to systemic lupus erythematosus. 21 Until now, no report of OPN levels in patients with psoriasis has been published in the literature.…”

mentioning

confidence: 99%