Osteopontin‐integrin α<sub>v</sub>β<sub>3</sub> axis is crucial for 5‐fluorouracil resistance in oral squamous cell carcinoma

Nakamura, Takuya; Shinriki, Satoru; Jono, Hirofumi; Ueda, Mitsuharu; Nagata, Masashi; Guo, Jianying; Hayashi, Mitsuhiro; Yoshida, Ryoji; Ota, Tomoko; Ota, Kazutoshi; Kawahara, Katsunobu; Nakagawa, Yoshihiro; Yamashita, Satoshi; Nakayama, Hideki; Hiraki, Akimitsu; Shinohara, Masanori; Ando, Yumiko

doi:10.1016/j.febslet.2014.12.004

Cited by 15 publications

(10 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The mean age of patients was 25.57 years in the nine studies that reported the age of patients in this systematic review. Among all, the mean age reported by Yang et al, 16 which was 59 years, and the mean age reported by Nakamura et al, 22 which was 55.5 years, were closer to our results. In our study, the percentage of patients taking cisplatin was higher than patients using 5-FU; nonetheless, the mean frequency percentage of cisplatin resistance was lower than that of 5-FU resistance.…”

Section: Discussionsupporting

confidence: 90%

“…Another study found that the expression of osteopontin resulted in poor response to treatment and survival of cancer cells. 11 , 22 Since the medications used in the aforementioned two studies were different, it might be concluded that the type of drug resistance cannot be exclusive to one type of medication. Another cause of the emergence of drug resistance is the increased expression of pro-inflammatory cytokines in the path of drug uptake by cancer cells, which affects the drug efficacy.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

Atashi

Vahed

Emamverdizadeh

et al. 2021

J Dent Res Dent Clin Dent Prospects

View full text Add to dashboard Cite

Head and neck cancers are highly prevalent worldwide. Most of these lesions are diagnosed in the advanced stages of the disease. Thus, they do not often have a good long-term prognosis. Like other cancer types, head and neck cancers are managed by surgery, radiotherapy, and chemotherapy. Despite significant advances in the treatment of oral squamous cell carcinoma (OSCC), physicians encounter several challenges in the course of treatment. Various mechanisms mediate the clinical responses of a certain cancer to medications. Thus, efficient treatment planning requires adequate knowledge about the genes involved in drug resistance and the evaluation of the frequency percentage of resistance. Several studies have evaluated the causes and frequency percentages of 5-fluorouracil (5-FU) and cisplatin resistance. In this systematic review, all the relevant articles published until November 30, 2019, were retrieved from the Scopus, Embase, Medline, ISI, Web of Science, and Cochrane databases using certain MeSH and EMTTree keywords. A total of 2164 articles were retrieved of which, 18 were included in the review since they had reported the frequency percentages of drug resistance. Of all, 10 articles had evaluated cisplatin (1317 samples). A meta-analysis of the results revealed a frequency of 33% for cisplatin resistance. Eight studies had evaluated 5-FU (476 samples). A meta-analysis of the results revealed a frequency of 40.2 % for 5-FU resistance. Overcoming cisplatin resistance or 5-FU resistance can significantly enhance recovery in advanced HNSCC. Attempts should be made to eliminate the cause and use multi-drug regimens to increase the success rate of treatment.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

Atashi

Vahed

Emamverdizadeh

et al. 2021

J Dent Res Dent Clin Dent Prospects

View full text Add to dashboard Cite

show abstract

“…Resistance to this drug is a significant obstacle to its successful clinical application in oral cancer (Longley et al., 2003). The OPN overexpression contributed to 5‐FU resistance in OSCC via integrin αvβ3 (Nakamura et al., 2015). The pharmacological inhibition of integrin αvβ3 may help overcome resistance to 5‐FU‐based therapy (Nakamura et al., 2015).…”

Section: Clinical Perspective In the Use Of Osteopontinmentioning

confidence: 99%

“…The OPN overexpression contributed to 5‐FU resistance in OSCC via integrin αvβ3 (Nakamura et al., 2015). The pharmacological inhibition of integrin αvβ3 may help overcome resistance to 5‐FU‐based therapy (Nakamura et al., 2015).…”

Section: Clinical Perspective In the Use Of Osteopontinmentioning

confidence: 99%

The role of osteopontin in oral cancer: A brief review with emphasis on clinical applications

et al. 2020

View full text Add to dashboard Cite

Osteopontin (OPN) is a calcium-binding glycol-phosphoprotein present in many physiologic and pathological processes. This protein can control bone cell adhesion, osteoclastic activity, and bone matrix mineralization. However, its participation in pathological processes such as atherosclerosis, sarcoidosis, tuberculosis, and cancer have been described. Some studies have shown that OPN may participate in the development and progression of oral cancer. Although the role of OPN in oral cancer is not fully understood, some studies have suggested that this protein may induce malignant phenotype of cells by activation of PI3K/AKT/mTOR pathway, which favors cell proliferation, invasion, metastasis, angiogenesis, and failure of treatment. This review discusses the possible mechanism of involvement of OPN in oral cancer and its potential clinical application in diagnosis and prognosis.

show abstract

“…Показано, что использование антитела против αvβ3 почти полностью подавляет резистентность клеток к 5-фторурацилу. Авторы полагают, что фармакологическое блокирование связи интегрина αvβ3 с остеопонтином в сочетании с химиотерапией 5-фторурацилом позволит добиться значительно лучших результатов в лечении плоскоклеточного рака челюстно-лицевой области [40]. В работе N. Stojanović и соавт.…”

Section: обзорные статьиunclassified

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Tuguzbaeva¹,

Павлов²

2019

Usp. mol. onkol

View full text Add to dashboard Cite

The initiation of carcinoma progression is attributed to significant disorders in the synthesis of macromolecules that affect physiological processes in the epithelial cells of oral mucosa. It is known that the integrin family receptors are crucial for regenerative and reparative functions of the normal epithelium. In addition to their well-established physiological role, some types of integrins are the major determinants of malignant transformations. In particular, the results of recent studies in molecular oncology reveal the importance of αv integrins in the pathogenesis of carcinomas, including oral squamous cell carcinoma. This review aims to analyse the significance of αv integrins in the key processes of malignant growth and metastasis of oral squamous cell carcinoma. The prospects of using αv integrins as prognostic molecular markers and targets for developing novel diagnostic and therapeutic methods in the management of oral cancer are discussed.

show abstract

Osteopontin‐integrin α_vβ₃ axis is crucial for 5‐fluorouracil resistance in oral squamous cell carcinoma

Cited by 15 publications

References 51 publications

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

The role of osteopontin in oral cancer: A brief review with emphasis on clinical applications

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Contact Info

Product

Resources

About

Osteopontin‐integrin αvβ3 axis is crucial for 5‐fluorouracil resistance in oral squamous cell carcinoma

Cited by 15 publications

References 51 publications

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

Drug resistance against 5-fluorouracil and cisplatin in the treatment of head and neck squamous cell carcinoma: A systematic review

The role of osteopontin in oral cancer: A brief review with emphasis on clinical applications

The role of integrins αv in the pathogenesis of oral squamous cell carcinoma

Contact Info

Product

Resources

About

Osteopontin‐integrin α_vβ₃ axis is crucial for 5‐fluorouracil resistance in oral squamous cell carcinoma