Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis

Choi, Seong-Ho; Kim, J. H.; Kang, Eun-Jin; Lee, S.-W.; Park, M.-C.; Park, Y.-B.

doi:10.1093/rheumatology/ken385

Cited by 115 publications

(85 citation statements)

References 27 publications

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“…All of the later stage osteogenic markers (e.g., Osx, Ocn, Opn, BSP) suggest that skeletal development process was successfully recapitulated and led to the formation of mature osteoblasts and osteocytes. During the second and third week of 3-D osteo-differentiatiation CNCCs demonstrate the expression of i) OSX, a bone-specific transcription factor that is specifically expressed in osteoblasts of all skeletal elements [41], ii) OCN, an osteoblastderived hormone expressed only in fully differentiated osteoblasts and osteocytes, iii) OPN, a late osteogenic protein that regulates the biomineralization and boneremodelling [42,43] and iv) BSP, a non-collagenous protein that is a key component of the bone extracellular matrix [44,45] (Figure 3E, F, Figure 4B, C, E, F, G and Supplementary Figure 2). The formation of mature bone tissue is further characterized by the mineralization in terms of hydroxyapatite deposition in the newly formed extracellular matrix [46].…”

Section: Discussionmentioning

confidence: 99%

Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments

et al. 2016

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The experimental systems that recapitulate the complexity of native tissues and enable precise control over the microenvironment are becoming essential for the pre-clinical tests of therapeutics and tissue engineering. Here, we described a strategy to develop an in vitro platform to study the developmental biology of craniofacial osteogenesis. In this study, we directly osteo-differentiated cranial neural crest cells (

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Section: Discussionmentioning

confidence: 99%

Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments

et al. 2016

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“…The transcriptional level of tmsb15a in the pituitary gland was dramatically decreased at 90 than at 45 dpf (Table 2). Sparc, scpp7, and ogn are important humoral bone anabolic factors involved in bone mineralization, formation, and remodeling (Choi et al 2008, Delany & Hankenson 2009, Tanaka et al 2012. The expression levels of these three transcripts decreased significantly from the juvenile to the sexual maturity stage (Table 2) and might be involved in the regulation of skeletal development and growth after sex maturation.…”

Section: Discussionmentioning

confidence: 99%

Zebrafish pituitary gene expression before and after sexual maturation

He¹,

Dai²,

Chen³

et al. 2014

Journal of Endocrinology

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Sexual maturation and somatic growth cessation are associated with adolescent development, which is precisely controlled by interconnected neuroendocrine regulatory pathways in the endogenous endocrine system. The pituitary gland is one of the key regulators of the endocrine system. By analyzing the RNA sequencing (RNA-seq) transcriptome before and after sexual maturation, in this study, we characterized the global gene expression patterns in zebrafish pituitaries at 45 and 90 days post-fertilization (dpf). A total of 15 043 annotated genes were expressed in the pituitary tissue, 3072 of which were differentially expressed with a greater than or equal to twofold change between pituitaries at 45 and 90 dpf. In the pituitary transcriptome, the most abundant transcript was gh. The expression levels of gh remained high even after sexual maturation at 90 dpf. Among the eight major pituitary hormone genes, lhb was the only gene that exhibited a significant change in its expression levels between 45 and 90 dpf. Significant changes in the pituitary transcripts included genes involved in the regulation of immune responses, bone metabolism, and hormone secretion processes during the juvenile-sexual maturity transition. Real-time quantitative PCR analysis was carried out to verify the RNA-seq transcriptome results and demonstrated that the expression patterns of the eight major pituitary hormone genes did not exhibit a significant gender difference at 90 dpf. For the first time, we report the quantitative global gene expression patterns at the juvenile and sexual maturity stages. These expression patterns may account for the dynamic neuroendocrine regulation observed in body metabolism.

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“…It is secreted by various tissues such as fibroblasts [82] and immune cells, including dendritic cells, macrophages, and neutrophils [83]. Osteopontin is known to interact with various surface receptors that make it a crucial player in bone remodeling [84], wound healing, inflammation, and immune responses [83]. It is also known to be involved in vascular remodeling during endothelial injury [82].…”

Section: Minor Ecm Components In Heart Valves Also Play Significant Rmentioning

confidence: 99%

Extracellular Matrix Organization, Structure, and Function

Wiltz¹,

Arevalos²,

Balaoing³

et al. 2013

Calcific Aortic Valve Disease

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Osteopontin might be involved in bone remodelling rather than in inflammation in ankylosing spondylitis

Abstract: Patients with AS had higher levels of OPN compared with controls. The plasma OPN level was correlated with serum ALP, OCN and CTX-I levels, but not with disease activity in AS. OPN might be involved in bone remodelling rather than in inflammation in AS.

Cited by 115 publications

References 27 publications

Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments

Recapitulating cranial osteogenesis with neural crest cells in 3-D microenvironments

Zebrafish pituitary gene expression before and after sexual maturation

Extracellular Matrix Organization, Structure, and Function

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