Osteoporosis

Lane, Joseph M.; Russell, Linda; Khan, Safdar N.

doi:10.1097/00003086-200003000-00016

Cited by 295 publications

(158 citation statements)

References 41 publications

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“…Osteoporosis is defined as a disorder of decreased bone mass, commonly seen in postmenopausal women, and is associated estrogen deficiency (11). Previous studies have reported a correlation between osteoporosis and periodontitis with older age and cytokines production with respect to enhanced osteoclast-mediated resorption of skeletal and alveolar bone (12).…”

Section: Introductionmentioning

confidence: 99%

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

et al. 2017

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Section: Introductionmentioning

confidence: 99%

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

et al. 2017

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“…These fractures, like osteoporosis in general, occur with increased frequency in women. 3 The spine contains the greatest volume of metabolically active trabecular bone in the body. 4 The loss of these same trabeculations is one of the defining features of osteoporosis.…”

Section: Introductionmentioning

confidence: 99%

The Use of Computed Tomography Attenuation to Evaluate Osteoporosis Following Acute Fractures of the Thoracic and Lumbar Vertebra

Emohare

Cagan

Morgan

et al. 2014

Geriatr Orthop Surg Rehabil

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Background: Relatively few patients have dual-energy x-ray absorptiometry to quantify the magnitude of bone loss as they age. Recent work correlates mean computed tomography (CT) attenuation in the level I (L1) vertebra with bone mineral density (BMD), making it possible to objectively evaluate the magnitude of bone loss in osteoporosis by this method. The aims of this study were to evaluate the utility of using CT scans in patients with acute thoracic and lumbar spine fractures to diagnose osteoporosis and using CT attenuation to evaluate the association between age and BMD. Methods: We performed a retrospective study of patients with acute fractures of the thoracic or lumbar spine who had also undergone an abdominal (or L1) CT scan and compared mean CT attenuation in L1 against threshold values. We also compared differences in CT attenuation between younger (<65 years) and older (!65 years) and older patients. Results: A total of 124 patients were evaluated (74 thoracic and 50 lumbar fractures). Overall, there was a strong correlation between age and bone density as measured by CT attenuation (r ¼ À.76). Among those with thoracic fractures (<65 years), mean CT attenuation was 196.51 HU. Forty-one patients were !65 years and had mean CT attenuation of 105.90 HU (P < .001). In patients with lumbar fractures, 27 patients were <65 years and had a mean CT attenuation of 192.26 HU and 23 patients were !65 years and had mean CT attenuation of 114.31 HU (P < .001). At the threshold of 110 HU, set for specificity, the magnitude of difference between the age-stratified cohorts was greater in the thoracic spine (P < .0001 vs P ¼ .003). Discussion: Using opportunistic CT, we demonstrate the relative frequency of osteoporosis in patients with acute fractures of the thoracic and lumbar spine and confirm that the association increases with age. The CT attenuation may provide a cheap and convenient method to help confirm a clinical diagnosis of osteoporosis in patients with fractures.

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“…[1][2][3] Typically, they are caused by everyday movements such as stooping or lifting, which increases loading on the spine. 3,4 Fractures can be painful, and they often lead to progressive deformity and disability.…”

mentioning

confidence: 99%

Intervertebral Disc Degeneration Can Lead to “Stress-Shielding” of the Anterior Vertebral Body

Pollintine¹,

Dolan²,

Tobias³

et al. 2004

Spine

171

127

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Osteoporosis

Cited by 295 publications

References 41 publications

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis

The Use of Computed Tomography Attenuation to Evaluate Osteoporosis Following Acute Fractures of the Thoracic and Lumbar Vertebra

Intervertebral Disc Degeneration Can Lead to “Stress-Shielding” of the Anterior Vertebral Body

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