Osteoporosis and metabolic syndrome according to socio‐economic status, contribution of <scp>PTH</scp>, vitamin D and body weight: The Canarian Osteoporosis Poverty Study (<scp>COPS</scp>)

Navarro, Marlene Isabel Hernández; Saavedra, Pedro; Jódar, Esteban; Tejada, Ma Jesús Gómez de; Mirallave, Ana; Sosa, Manuel

doi:10.1111/cen.12051

Cited by 43 publications

(37 citation statements)

References 36 publications

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“…Low socio-economic status has been associated with 25-OHD insufficiency, higher values of PTH, lower values of BMD and a higher prevalence of fragility fractures. 53 Also, despite lower serum 25-hydroxyvitamin D concentrations and dietary calcium intake and, African Americans have higher BMD and develop osteoporosis less frequently than do European Americans. 54 Our Medicare analysis showed a significant interaction of socioeconomic variables (education and income), but also of race and obesity, confirming those previous factors.…”

Section: Discussionmentioning

confidence: 99%

Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies

Prada

Zhong

Colicino

et al. 2017

The Lancet Planetary Health

113

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Background Air particulate matter (PM) is a ubiquitous environmental exposure associated with oxidation, inflammation, and age-related chronic disease. Whether PM is associated with loss of bone mineral density (BMD) and risk of bone fractures is undetermined. Methods We conducted two complementary studies of: (i) long-term PM <2.5 μm (PM2.5) levels and osteoporosis-related fracture hospital admissions among 9.2 million Medicare enrollees of the Northeast/Mid-Atlantic United States between 2003–2010; (ii) long-term black carbon [BC] and PM2.5 levels, serum calcium homeostasis biomarkers (parathyroid hormone, calcium, and 25-hydroxyvitamin D), and annualized BMD reduction over a 8-year follow-up of 692 middle-aged (46.7±12.3 yrs), low-income BACH/Bone cohort participants. Findings In the Medicare analysis, risk of bone fracture admissions at osteoporosis-related sites was greater in areas with higher PM2.5 levels (Risk ratio [RR] 1.041, 95% Confidence Interval [CI], 1.030, 1.051). This risk was particularly high among low-income communities (RR 1.076; 95% CI, 1.052, 1.100). In the longitudinal BACH/Bone study, baseline BC and PM2.5 levels were associated with lower serum PTH (Estimate for baseline one interquartile increase in 1-year average BC= −1.16, 95% CI −1.93, −0.38; Estimate for baseline one interquartile increase in 1-year average PM2.5= −7.39; 95%CI −14.17, −0.61). BC level was associated with higher BMD loss over time at multiple anatomical sites, including femoral neck (−0.08%/year per one interquartile increase; 95% CI −0.14, −0.02%/year) and ultradistal radius (−0.06%/year per one interquartile increase; 95% CI −0.12, −0.01%/year). Interpretation Our results suggest that poor air quality is a modifiable risk factor for bone fractures and osteoporosis, especially in low-income communities.

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Section: Discussionmentioning

confidence: 99%

Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies

Prada

Zhong

Colicino

et al. 2017

The Lancet Planetary Health

113

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“…Oral health behaviors are also associated with sociodemographic factors such as education level and economic status [33,34]. In many studies, low education level and low income were related to decreased BMD [35][36][37]. Therefore, subjects with good oral health behavior could also have positive behavioral and environmental factors for bone health.…”

Section: Discussionmentioning

confidence: 99%

Oral health behaviors and bone mineral density in South Korea: the 2008–2010 Korean National Health and Nutrition Examination Survey

Kim

Cho

et al. 2015

J Bone Miner Metab

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The purpose of this study was to examine the association between oral health behaviors and bone mineral density (BMD) by using data from the Korean National Health and Nutrition Examination Survey conducted in 2008-2010. We included 6,620 subjects (3,140 men aged more than 50 years and 3,480 postmenopausal women). BMD was measured at three sites-namely, the lumbar spine, total femur, and femur neck. Oral health behaviors were assessed by use of a self-administered questionnaire in the Korean National Health and Nutrition Examination Survey. After adjustment for all covariates, BMD of the lumbar spine and femur neck tended to increase as the frequency of tooth brushing increased in men (p trend = 0.020 and p trend = 0.028, respectively). Women using secondary oral products had increased lumbar spine BMD compared with women who did not use secondary oral products. However, after adjustment for all covariates, no significant relationship was observed between BMD and the use of secondary oral products. As the frequency of tooth brushing and the number of secondary oral products used increased, the prevalence of osteoporosis decreased. The frequency of tooth brushing is associated with increased lumbar spine and femur neck BMD in South Korean men.

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“…The prevalence of deficiency is even higher in patients with risk factors for having low blood levels of vitamin D, obese people and those in poverty 42 . Therefore, vitamin D deficiency in Spain is not a myth (a person or a thing to which are attributed qualities or benefits they do not possess, or even a reality which they lack), but a reality with significant repercussions on bone health and probably on the health of the organism as a whole.…”

Section: State Of Vitamin D Insufficiency In Spainmentioning

confidence: 99%

Deficiencia de vitamina D en España: ¿realidad o mito?

Valverde

Gómez

2014

Rev Osteoporos Metab Miner

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Vitamin D 3 (colecalciferol) is formed from its precursor 7-dehydrocholesterol in the skin by ultraviolet irradiation. In the liver the vitamin D 3 is hydroxylated to form 25-hydroxyvitamin D 3 , which is metabolised to its active metabolite 1,25-dihydroxyvitamin D 3 preferentially in the kidney. Vitamin D 3 may also be provided in the diet, which is a significant source of supply only in the case of insufficient exposure to sunlight. Blue fish naturally contains large quantities of vitamin D 3 , while other foods contain significant quantities of vitamin D only after being fortified. For fortification, in many countries vitamin D 2 is used (ergocalciferol) obtained from vegetable sources 1 . The presence of the enzyme CYP27B1, which drives the synthesis of dihydroxyvitamin D from its principal substrate, 25-hydroxyvitamin D, and the vitamin D receptor (VDR), distributed almost universally in the cells and tissues of the organism, confers on vitamin D (although it would be increasingly more correct to say the endocrine system of vitamin D) a broad role in health. This is not only in the regulation of calcium and bone metabolism but also in relation to the cardiovascular system, innate or acquired immunomodulation, the regulation of cell growth, etc., such that around 3% of the human genome is regulated by the hormone 1,25(OH) 2 vitamin D 3 1-3 . It is therefore not surprising that basic scientific and clinical interest in vitamin D 4 , as well as interest in the non-specialist press and in the general population 5 , has increased almost exponentially in the last decade. 25-hydroxyvitamin D, marker for the status of vitamin D in the bodyFor some years there has been universal consensus that the measurement of the levels of the metabolite 25-hydroxyvitamin D in the blood is the marker for the status of vitamin D in the body, including the endogenous synthesis due to exposure to sunlight, dietary consumption in foods, supplemented or not, and pharmacological treatments 1,2

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Osteoporosis and metabolic syndrome according to socio‐economic status, contribution of PTH, vitamin D and body weight: The Canarian Osteoporosis Poverty Study (COPS)

Cited by 43 publications

References 36 publications

Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies

Association of air particulate pollution with bone loss over time and bone fracture risk: analysis of data from two independent studies

Oral health behaviors and bone mineral density in South Korea: the 2008–2010 Korean National Health and Nutrition Examination Survey

Deficiencia de vitamina D en España: ¿realidad o mito?

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