Osteoporosis: Emerging targets on the classical signaling pathways of bone formation

Li, Si-yan; Xue, Si-tu; Li, Zhuo-rong

doi:10.1016/j.ejphar.2024.176574

European Journal of Pharmacology

2024

DOI: 10.1016/j.ejphar.2024.176574

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Osteoporosis: Emerging targets on the classical signaling pathways of bone formation

Si-yan Li,

Si-tu Xue,

Zhuo-rong Li

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Cited by 2 publications

References 110 publications

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USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression

Zhou,

Mu,

Zhang

et al. 2024

Biochemical Pharmacology

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USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression

Zhou,

Mu,

Zhang

et al. 2024

Biochemical Pharmacology

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Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

Chen,

Xiao,

Liu

et al. 2024

Biomolecules

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Osteoporosis (OP) is a common metabolic bone disease characterized by low bone mass, decreased bone mineral density, and degradation of bone tissue microarchitecture. However, our understanding of the mechanisms of bone remodeling and factors affecting bone mass remains incomplete. Sirtuin1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent deacetylase that regulates a variety of cellular metabolisms, including inflammation, tumorigenesis, and bone metabolism. Recent studies have emphasized the important role of SIRT1 in bone homeostasis. This article reviews the role of SIRT1 in bone metabolism and OP and also discusses therapeutic strategies and future research directions for targeting SIRT1.

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Osteoporosis: Emerging targets on the classical signaling pathways of bone formation

Cited by 2 publications

References 110 publications

USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression

USP10-mediated deubiquitination of NR3C1 regulates bone homeostasis by controlling CST3 expression

Sirt1: An Increasingly Interesting Molecule with a Potential Role in Bone Metabolism and Osteoporosis

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