Osteoprotegerin in pregnant adolescents differs by race and is related to infant birth weight <i>z</i>-score

Essley, Bridget V.; McNanley, Thomas; Cooper, B.; McIntyre, Allison W.; Witter, Frank R.; Harris, Z. Leah; O’Brien, Kimberly

doi:10.1017/s2040174411000511

Cited by 16 publications

(20 citation statements)

References 44 publications

(95 reference statements)

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“…During the third trimester, 1,25(OH) 2 D was a significant determinant of VO+, and dietary calcium intake at the third trimester was not significantly related to VO+, maternal 1,25(OH) 2 D, or PTH. A similar lack of a relation between dietary calcium intake and either 1,25(OH) 2 D (20) or bone turnover markers at either mid-or late gestation (46) has recently been reported in a cohort of 171 pregnant adolescents. In contrast, in each of our study groups at postpartum and in the entire cohort, dietary calcium intake was significantly positively associated with increased VO+.…”

Section: Discussionsupporting

confidence: 68%

Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

O’Brien¹,

Donangelo²,

Ritchie³

et al. 2012

The American Journal of Clinical Nutrition

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Section: Discussionsupporting

confidence: 68%

Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

O’Brien¹,

Donangelo²,

Ritchie³

et al. 2012

The American Journal of Clinical Nutrition

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“…The study was approved by the institutional review boards of the University of Rochester and Cornell University. Data from this cohort were reported previously (21)(22)(23)(24)(25)(26).…”

Section: Participants and Methodsmentioning

confidence: 99%

Maternal Inflammation at Delivery Affects Assessment of Maternal Iron Status

Lee

Guillet

Cooper

et al. 2014

The Journal of Nutrition

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Pregnant adolescents (aged ≤ 18 y, n = 253) were followed from ≥ 12 wk of gestation to delivery to assess longitudinal changes in anemia and iron status and to explore associations between iron status indicators, hepcidin, and inflammatory markers. Hemoglobin, soluble transferrin receptor (sTfR), ferritin, serum iron, erythropoietin (EPO), hepcidin, C-reactive protein, interleukin-6 (IL-6), folate, and vitamin B-12 were measured, and total body iron (TBI) (milligrams per kilogram) was calculated using sTfR and ferritin values. Anemia prevalence increased from trimesters 1 and 2 (3-5%, <28 wk) to trimester 3 (25%, 33.2 ± 3.7 wk, P < 0.0001). The prevalence of iron deficiency (sTfR > 8.5 mg/L) doubled from pregnancy to delivery (7% to 14%, P = 0.04). Ferritin and hepcidin concentrations at delivery may have been elevated as a consequence of inflammation because IL-6 concentrations at delivery were 1.6-fold higher than those obtained at 26.1 ± 3.3 wk of gestation (P < 0.0001), and a positive association was found between IL-6 and both hepcidin and ferritin at delivery (P < 0.01). EPO was consistently correlated with hemoglobin (r = -0.36 and -0.43, P < 0.001), ferritin (r = -0.37 and -0.32, P < 0.0001), sTfR (r = 0.35 and 0.25, P < 0.001), TBI (r = -0.44 and -0.37, P < 0.0001), and serum iron (r = -0.22 and -0.16, P < 0.05) at mid-gestation and at delivery, respectively. EPO alone explained the largest proportion of variance in hemoglobin at 26.0 ± 3.3 wk of gestation (R(2) = 0.13, P = 0.0001, n = 113) and at delivery (R(2) = 0.19, P < 0.0001, n = 192). Pregnant adolescents are at high risk of anemia. EPO is a sensitive indicator of iron status across gestation, is not affected by systemic inflammation, and may better predict risk of anemia at term. The trial was registered at clinicaltrials.gov as NCT01019902.

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“…Data on serum N-telopetide (NTX) were obtained using an ELISA assay (Ostex International, Seattle, WA) and osteocalcin (OC) was analyzed using an in-house ELISA assay in the lab of Dr. Caren Gundberg (Yale University as previously reported. 27 …”

Section: Methodsmentioning

confidence: 99%

Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents

Young

McNanley

Cooper

et al. 2011

Journal of Bone and Mineral Research

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Few large studies have assessed changes in calcitropic hormones and maternal 25(OH)D status across pregnancy, and how this may impact maternal bone turnover and neonatal hormone status. We aimed to identify determinants of 25(OH)D, PTH, and calcitriol across pregnancy in a longitudinal study of 168 pregnant adolescents (≤18 y of age). Maternal 25(OH)D, PTH, and calcitriol were assessed at mid-gestation (~26 weeks), delivery, and in cord blood. Data were related to measures of maternal anthropometrics, dietary intake, physical activity, and bone turnover markers. Approximately 50% of teens and their infants had serum 25(OH)D ≤20 ng/mL; 25(OH)D was lower in African Americans versus Caucasians (p<0.001). PTH increased across gestation (p<0.001). Elevated PTH (≥60 pg/mL) was detected in 25% of adolescents at delivery, and was associated with increased concentrations of serum NTX (p=0.028). PTH and calcitriol did not significantly differ across the range of Ca intakes consumed (257-3220 mg/day). In the group as a whole, PTH was inversely associated with 25(OH)D in maternal circulation at mid-gestation (p=0.023) and at delivery (p=0.019). However, when the cohort was partitioned by 25(OH)D status, this relationship was only present in those with 25(OH)D ≤20 ng/mL, suggestive of a threshold below which 25(OH)D impacts PTH during pregnancy. Mid-gestation 25(OH)D was inversely associated with calcitriol at delivery (p=0.023), irrespective of Ca intake. Neonatal PTH and calcitriol were significantly lower than (p<0.001), but unrelated to maternal concentrations. These findings indicate that maternal 25(OH)D status plays a role in calcitropic hormone regulation in pregnant adolescents.

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Osteoprotegerin in pregnant adolescents differs by race and is related to infant birth weight z-score

Cited by 16 publications

References 44 publications

Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

Serum 1,25-dihydroxyvitamin D and calcium intake affect rates of bone calcium deposition during pregnancy and the early postpartum period

Maternal Inflammation at Delivery Affects Assessment of Maternal Iron Status

Vitamin D insufficiency is prevalent and vitamin D is inversely associated with parathyroid hormone and calcitriol in pregnant adolescents

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