Osteoradionecrosis of the Mandible: Treatment With Hyperbaric Oxygen

Major healing of refractory mandible osteoradionecrosis after treatment combining pentoxifylline and tocopherol: A phase II trial

“…As early as 1973, HBO was reported to be effective as an adjunctive treatment for ORN. 21 However, the results reported for HBO in the literature vary considerably (Table 3) and range from 15% to 43% recovery after HBO alone versus 18% to 90% after HBO combined with limited surgery. 2,22 -31 This limited retrospective published experience soon established that without aggressive surgical management, HBO would not resolve the disease process in most cases.…”

Osteorradionecrose em pacientes submetidos à radioterapia de cabeça e pescoço: relato de caso

“…Nos casos de baixo risco, os pacientes são orientados e motivados a manter os dentes com medidas preventivas, que incluem orientação de higiene bucal, utilização de flúor tópico em domicílio, visitas regulares ao dentista para detecção e tratamento de cáries e problemas periodontais incipientes 15 . Após iniciado o tratamento irradiante, o paciente deve ser acompanhado semanalmente durante toda a terapia, visando minimizar os efeitos imediatos da radiação, como, por exemplo, a mucosite e a xerostomia, com soluções específicas como laserterapia e saliva artificial [16][17][18][19] .…”

A cost effectiveness analysis of hyperbaric therapy in osteoradionecrosis

“…Claims that pathological fractures would unite without surgery, that fibrous unions would unite without bone grafts and that orocutaneous fistulae would heal with HBO alone were reported (9,10). According to Marx (11), "The single most important reason nonsurgical and conservative surgical approaches are associated with such statistically poor results is that they fail to address the basic pathophysiology of the disease".…”