Osteosarcoma at the site of previous fracture. A case report.

Berry, Micah; Jenkin, R. D. T.; Fornasier, Victor; Rideout, D. F.

doi:10.2106/00004623-198062070-00030

Cited by 8 publications

(5 citation statements)

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“…In 1933, Coley and Higinbotham reported 360 cases of bone sarcoma, of which 181 (50%) had histories of trauma, and 205 cases of breast carcinoma of which 70 (34%) were associated with trauma [12]. An impressive series has suggested trauma as a cause of bone cancer [13], and a review of post-surgical bone cancers associated with metal implants identified 22 various bone tumors, 17 since 1980 [14]. Several studies have also observed an increased relative risk of carcinoma associated with a history of nasal trauma or injury [15].…”

Section: Discussionmentioning

confidence: 99%

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Hashmi

Zolfaghari

Levine

2012

Cancers

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The phenomenon of accelerated tumor growth following surgery has been observed repeatedly and merits further study. Inflammatory breast carcinoma (IBC) is widely recognized as an extremely aggressive malignancy characterized by micrometastasis at the time of diagnosis, with one interesting subgroup defined as secondary IBC where pathologically identifiable IBC appears after surgical treatment of a primary non-inflammatory breast cancer. One possible mechanism can be related to the stimulation of dormant micrometastasis through local angiogenesis occurring as part of posttraumatic healing. In this report, we review cases of secondary IBC and others where localized trauma was followed by the appearance of IBC at the traumatized site that have been identified by our IBC Registry (IBCR) and hypothesize that angiogenesis appearing as part of the healing process could act as an accelerant to an otherwise latent breast malignancy. It is therefore possible that secondary IBC can be used as a model to support local angiogenesis as an important contributor to the development of an aggressive cancer.

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Section: Discussionmentioning

confidence: 99%

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Hashmi

Zolfaghari

Levine

2012

Cancers

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“…For instance, an osteosarcoma at the site of a previous fracture that had no fixation devices has been described (Berry et al 1980) and some reports have shown the presence of a metastatic tumor at the site of a metallic implant. In these cases, the presence of the tumor is coincidental (Allain et al 1998).…”

Section: Discussionmentioning

confidence: 99%

Fibrosarcoma at the site of a metallic fixation of the tibia--a case report and literature review

Hinarejos¹,

Escuder²,

Monllau³

et al. 2000

Acta Orthopaedica Scandinavica

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“…Our literature search yielded only two reported cases in humans. Berry et al reported a 12-year-old boy who developed osteosarcoma at a healed midshaft femoral fracture seven years after a multiple high-energy trauma [ 5 ]. Another case reported by Rao et al described a 14-year-old boy who sustained a midshaft femoral fracture following a bicycle accident [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Genesis and Symptom Interval of Osteosarcoma Following High-Energy Trauma

Sharifudin¹,

Khaw²,

Sayuti³

et al. 2021

Cureus

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We report three cases of femoral fracture, which subsequently developed osteosarcoma within the course of illness. The first patient presented with a spiral fracture treated with an interlocking femoral nail. He presented five months later with a painful knee swelling and was diagnosed with osteosarcoma. He was asymptomatic despite initial radiographs showed osteolysis at the distal metaphysis. The fracture united well and no evidence of marrow or soft tissue contamination. The second patient had a distal femoral fracture and underwent plate stabilization. Osteosarcoma developed at the united fracture site three years later. Both survived six to seven years without evidence of disease following the standard treatment protocol. The third patient had a closed distal third fracture treated with dynamic compression plating. He presented with an osteoblastic lesion in the proximal femur three years later. There was no initial radiological evidence of osteosarcoma one year before the clinical manifestation of the disease.

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Osteosarcoma at the site of previous fracture. A case report.

Cited by 8 publications

References 0 publications

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Does Secondary Inflammatory Breast Cancer Represent Post-Surgical Metastatic Disease?

Fibrosarcoma at the site of a metallic fixation of the tibia--a case report and literature review

Genesis and Symptom Interval of Osteosarcoma Following High-Energy Trauma

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