Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss

Lin, Longshuai; Wang, Hongjie; Guo, Weihong; He, Enjun; Huang, Kai; Zhao, Qinghua

doi:10.1016/j.cellsig.2021.109935

Cited by 13 publications

(10 citation statements)

References 40 publications

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“…Osteosarcoma-derived exosomes promote osteoclast differentiation and bone resorption activity, thus affecting the tumor microenvironment, which may be important for the changes of osteoclast phenotype and endothelial cell activity [ 72 ]. Osteosarcoma miRNA-5013p exosomes promote the differentiation of osteochondral cells and aggravate bone loss through the PTEN/PI3K/Akt pathway and upregulation of RANKL/NFAcTc1 [ 73 ]. MiRNA-19a-3p exosomes can also have a similar role [ 74 ].…”

Section: Oncologic Disease Environmentmentioning

confidence: 99%

Review of the Role of Mesenchymal Stem Cells and Exosomes Derived from Mesenchymal Stem Cells in the Treatment of Orthopedic Disease

2022

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Exosomes can be derived from mesenchymal stem cells (MSCs) and have recently been used to treat defects in the tendons. They may also have applications in treating osteoporosis. MSC-derived exosomes communicate with mesenchymal and osteogenic cells through endocrine or paracrine mechanisms and contribute factors involved in physiological and pathological orthopedic conditions associated with hypoxia and bone tumors. Also, generalized medical conditions, such as obesity, hyperglycemia, and degenerative diseases, can inhibit the osteogenic effect of MSC-derived exosomes. This review aims to present an update on the roles of MSCs and exosomes derived from MSCs in treating orthopedic diseases, such as osteoporosis, and in the repair of cartilage, tendons, and bone fractures.

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Section: Oncologic Disease Environmentmentioning

confidence: 99%

Review of the Role of Mesenchymal Stem Cells and Exosomes Derived from Mesenchymal Stem Cells in the Treatment of Orthopedic Disease

2022

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“…Under both physiological and pathological conditions, SEVs mediate the exchange of information between cells and their surroundings [145][146][147][148][149]. TEXs have emerged as a major communication mechanism between tumor cells and TMEs and have a vital role in tumor progression and metastasis [11,[150][151][152][153][154]. The application of TEXs in the diagnosis and treatment of glioma is still in the nascent stages.…”

Section: Future Prospections and Conclusionmentioning

confidence: 99%

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

2022

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Small extracellular vesicles (SEVs) are extracellular vesicles containing DNA, RNA, and proteins and are involved in intercellular communication and function, playing an essential role in the growth and metastasis of tumors. SEVs are present in various body fluids and can be isolated and extracted from blood, urine, and cerebrospinal fluid. Under both physiological and pathological conditions, SEVs can be released by some cells, such as immune, stem, and tumor cells, in a cytosolic manner. SEVs secreted by tumor cells are called tumor-derived exosomes (TEXs) because of their origin in the corresponding parent cells. Glioma is the most common intracranial tumor, accounting for approximately half of the primary intracranial tumors, and is characterized by insidious onset, high morbidity, and high mortality rate. Complete removal of tumor tissues by surgery is difficult. Chemotherapy can improve the survival quality of patients to a certain extent; however, gliomas are prone to chemoresistance, which seriously affects the prognosis of patients. In recent years, TEXs have played a vital role in the occurrence, development, associated immune response, chemotherapy resistance, radiation therapy resistance, and metastasis of glioma. This article reviews the role of TEXs in glioma progression, drug resistance, and clinical diagnosis.

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“…These products endowed sarcoma cells with malignant capacity and remodeled extracellular matrix for local invasion [40][41][42]. Particularly, exosomes from osteosarcoma cells might affect the differentiation and maturity of osteoclasts, the specialized cells originated from monocyte/macrophage lineage [43][44][45]. The exosomal miR-501-3p and pro-osteoclastic contents influence osteoclastogenesis, leading to sarcoma infiltration via aggravating osteolysis [43][44][45].…”

Section: Exosomes Mediate the Macrophage And Sarcoma Cell Interaction...mentioning

confidence: 99%

“…Particularly, exosomes from osteosarcoma cells might affect the differentiation and maturity of osteoclasts, the specialized cells originated from monocyte/macrophage lineage [43][44][45]. The exosomal miR-501-3p and pro-osteoclastic contents influence osteoclastogenesis, leading to sarcoma infiltration via aggravating osteolysis [43][44][45]. In addition to local spread, exosomes from sarcoma are strongly associated with its distant metastasis.…”

Section: Exosomes Mediate the Macrophage And Sarcoma Cell Interaction...mentioning

confidence: 99%

Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

Yang

et al. 2022

J Nanobiotechnol

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The current diagnosis and treatment of sarcoma continue to show limited timeliness and efficacy. In order to enable the early detection and management of sarcoma, increasing attentions have been given to the tumor microenvironment (TME). TME is a dynamic network composed of multiple cells, extracellular matrix, vasculature, and exosomes. Exosomes are nano-sized extracellular vesicles derived from various cells in the TME. The major function of exosomes is to promote cancer progress and metastasis through mediating bidirectional cellular communications between sarcoma cells and TME cells. Due to the content specificity, cell tropism, and bioavailability, exosomes have been regarded as promising diagnostic and prognostic biomarkers, and therapeutic vehicles for sarcoma. This review summarizes recent studies on the roles of exosomes in TME of sarcoma, and explores the emerging clinical applications.

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Osteosarcoma-derived exosomal miR-501-3p promotes osteoclastogenesis and aggravates bone loss

Cited by 13 publications

References 40 publications

Review of the Role of Mesenchymal Stem Cells and Exosomes Derived from Mesenchymal Stem Cells in the Treatment of Orthopedic Disease

Review of the Role of Mesenchymal Stem Cells and Exosomes Derived from Mesenchymal Stem Cells in the Treatment of Orthopedic Disease

Tumor-derived small extracellular vesicles: potential roles and mechanism in glioma

Exosomes in the tumor microenvironment of sarcoma: from biological functions to clinical applications

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