Osteotoxicity after chronic dietary administration of 13-cis-retinoic acid, retinyl palmitate or selenium in mice exposed to tumor initiation and promotion

Forsyth, K.S.; Watson, R. R.; Gensler, Helen L.

doi:10.1016/0024-3205(89)90081-7

Cited by 21 publications

(17 citation statements)

References 11 publications

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“…In laboratory animals, high levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions (5)(6)(7). The effects of carotenoids on bone metabolism, however, have not been fully clarified.…”

Section: Introductionmentioning

confidence: 99%

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Uchiyama

Yamaguchi²

2006

Int J Mol Med

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Abstract. The effect of ß-cryptoxanthin, a kind of carotenoid, on ovariectomy-induced bone loss was investigated. ß-Cryptoxanthin was isolated from Satsuma mandarin (Citrus unshu. MARC). ß-cryptoxanthin (5 or 10 μg/100 g body weight) was orally administered once daily for 3 months to ovariectomized (OVX) rats. OVX induced a significant increase in body weight and a significant decrease in serum calcium and inorganic phosphorus concentrations as compared with those of shamoperated (control) rats. These alterations induced by OVX were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). The analysis using a peripheral quantitative computed tomography (pQCT) showed that OVX induced a significant decrease in mineral content and mineral density in the femoral-diaphyseal and -metaphyseal tissues and polar strength strain index in the metaphyseal tissues. These decreases were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). Moreover, OVX induced a significant decrease in calcium content and alkaline phosphatase activity in the femoraldiaphyseal and -metaphyseal tissues and deoxyribonucleic acid (DNA) content in the metaphyseal tissues. These decreases were significantly prevented by the administration of ß-cryptoxanthin (5 or 10 μg/100 g). This study demonstrates that ß-cryptoxanthin has a preventive effect on OVX-induced bone loss in vivo.

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Section: Introductionmentioning

confidence: 99%

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Uchiyama

Yamaguchi²

2006

Int J Mol Med

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“…High levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions in animals. [15][16][17] β-Cryptoxanthin is a carotenoid abundant in Satsuma mandarin orange (Citrus unshiu MARC.) and it is enzymatically converted from β-carotene (provitamin A) in plants.…”

Section: Introductonmentioning

confidence: 99%

Relationship between Serum β-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (Citrus unshiu) Containing β-Cryptoxanthin

Yamaguchi

Igarashi

Morita³

et al. 2005

JOURNAL OF HEALTH SCIENCE

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The relationship between the serum ␤-cryptoxanthin concentration and circulating biochemical markers of bone metabolism in healthy individuals with the intake of juice prepared from Satsuma mandarin (Citrus unshiu MARC.) containing ␤-cryptoxanthin was investigated. Twenty volunteers (10 men and ten women) were divided into two groups of 10 volunteers (5 men and 5 women) each, and each group was sequentially given juice (192 ml) containing two different amounts of ␤-cryptoxanthin once a day for 56 days as follows: either regular juice with naturally occurring ␤-cryptoxanthin 802 g/100 ml or reinforced juice containing ␤-cryptoxanthin 1500 g/100 ml. ␥-Carboxylated osteocalcin, which is a marker of bone formation, and bone tartrate-resistant acid phosphatase (TRAP), which is a marker of bone resorption, were assayed. The serum ␤-cryptoxanthin concentration was significantly increased with the intake of regular juice for 56 days. This increase was significantly enhanced by the intake of ␤-cryptoxanthin-reinforced juice. The intake of regular juice or of ␤-cryptoxanthin-reinforced juice for 56 days caused a significant increase in serum ␥-carboxylated osteocalcin and a significant decrease in serum bone TRAP activity. A positive relationship between serum ␤-cryptoxanthin and circulating ␥-carboxylated osteocalcin concentrations was found using the value obtained from all groups for before intake and with the intake of regular juice and ␤-cryptoxanthin-reinforced juice. A negative relationship between serum ␤-cryptoxanthin concentration and circulating TRAP activity was observed. This study shows that a relationship between serum ␤-cryptoxanthin and circulating bone metabolic markers is found in healthy individuals with the intake of juice containing ␤-cryptoxanthin.

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“…In laboratory animals, high levels of vitamin A lead to accelerated bone resorption, bone fractures, and osteoporotic bone lesions. [78][79][80] The eŠect of carotenoids on bone metabolism, however, have not been fully clariˆed. Carotenoids are present in fruit and vegetables.…”

Section: B-cryptoxanthin and Bone Metabolismmentioning

confidence: 99%

Regulatory Mechanism of Food Factors in Bone Metabolism and Prevention of Osteoporosis

Yamaguchi

2006

YAKUGAKU ZASSHI

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Aging induces a decrease in bone mass, and osteoporosis with its accompanying decrease in bone mass is widely recognized as a major public health problem. Bone loss with increasing age may be due to decreased bone formation and increased bone resorption. Pharmacologic and nutritional factors may prevent bone loss with aging, although chemical compounds in food and plants which act on bone metabolism are poorly understood. We have found that iso‰avones (including genistein and daidzein), which are contained in soybeans, have a stimulatory eŠect on osteoblastic bone formation and an inhibitory eŠect on osteoclastic bone resorption, thereby increasing bone mass. Menaquinone-7, an analogue of vitamin K 2 which is abundant in fermented soybeans, has been demonstrated to stimulate osteoblastic bone formation and to inhibit osteoclastic bone resorption. Of various carotenoids, b-cryptoxanthin, which is abundant in Satsuma mandarin (Citrus unchiu MARC), has a stimulatory eŠect on osteoblastic bone formation and an inhibitory eŠect on osteoclastic bone resorption. The supplementation of these factors has a preventive eŠect on bone loss induced by ovariectomy in rats, which are an animal model of osteoporosis, and their intake has been shown to have a stimulatory eŠect on bone mass in humans. Factors with an anabolic eŠect on bone metabolism were found in extracts obtained from wasabi leafstalk (Wasabi japonica MATSUM), the marine alga Sargassum horneri, and bee pollen Cistus ladaniferus. Phytocomponent p-hydroxycinnamic acid was also found to have an anabolic eŠect on bone metabolism. Food chemical factors thus play a role in bone health and may be important in the prevention of bone loss with increasing age.

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Osteotoxicity after chronic dietary administration of 13-cis-retinoic acid, retinyl palmitate or selenium in mice exposed to tumor initiation and promotion

Cited by 21 publications

References 11 publications

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Relationship between Serum <I>β</I>-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (<I>Citrus unshiu</I>) Containing <I>β</I>-Cryptoxanthin

Regulatory Mechanism of Food Factors in Bone Metabolism and Prevention of Osteoporosis

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Osteotoxicity after chronic dietary administration of 13-cis-retinoic acid, retinyl palmitate or selenium in mice exposed to tumor initiation and promotion

Cited by 21 publications

References 11 publications

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Oral administration of β-cryptoxanthin prevents bone loss in ovariectomized rats

Relationship between Serum <I>&beta;</I>-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (<I>Citrus unshiu</I>) Containing <I>&beta;</I>-Cryptoxanthin

Regulatory Mechanism of Food Factors in Bone Metabolism and Prevention of Osteoporosis

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Relationship between Serum <I>β</I>-Cryptoxanthin and Circulating Bone Metabolic Markers in Healthy Individuals with the Intake of Juice (<I>Citrus unshiu</I>) Containing <I>β</I>-Cryptoxanthin