Ostertagia ostertagi: Excretory secretory chemotactic substance from infective larvae as cause of eosinophil locomotion

Klesius, Phillip H.; Haynes, T.B.; Cross, D.A.; Ciordia, H.

doi:10.1016/0014-4894(86)90142-6

Cited by 13 publications

(3 citation statements)

References 8 publications

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“…Although ECF and NCFs are widespread in parasites, no advantages to the parasite have been attributed to them, and the identity of many is not known beyond classifying them as proteins or glycoproteins in O. ostertagi L3 (Klesius et al 1986) and D. immitis (Horii et al 1986a, b) or peptides in S. japonicum eggs . Those which have been characterised are diverse, and many are similar to mammalian proteins: the ECF activity in Anopheles mosquito saliva is a member of the chitinase family with an MW around 66 kDa.…”

Section: Discussionmentioning

confidence: 99%

“…An eosinophil chemotactic factor (ECF) is not secreted by the free-living nematode Caenorhabditis elegans (Wildblood et al 2005), but is present in numerous parasitic cestodes (Horii et al 1984a;Potter and Leid 1986;Niwa et al 1998), trematodes (Owashi andIshii 1982;Horii et al 1984b;1986a), Anopheles saliva (Owhashi et al 2008), ES products of Psoroptes ovis (Wildblood and Jones 2007) and nematodes. These include L3, L4 and adult Teladorsagia circumcincta and Haemonchus contortus (Wildblood et al 2005), L3 Ostertagia ostertagi (Klesius et al 1985(Klesius et al , 1986, L3 Anisakis (Tanaka and Torisu 1978), adult Ascaris (Tanaka et al 1979), adult Angiostrongylus cantonensis (Ishida and Yoshimura 1990), adult Dirofilaria immitis (Owhashi et al 1996), Metastrongylus apri (Sasaki and Katsuno 1983), larval Trichinella spiralis and adult Trichuris muris (Dixon et al 2006). Neutrophil chemotactic factors (NCF) have been identified in parasitic cestodes (Horii et al 1984a) and trematodes (Horii et al 1984b;Jefferies et al 1996;Owhashi et al 2005), as well as Tritrichomonas foetus (Owhashi et al 1994), Necator americanus (Bower et al 2008), Oesophagostomum aculeatum , adult Ascaris (Tanaka et al 1979), D. immitis (Horii et al 1986b) and Oesophagostomum volvulus (Rubio de Krömer et al 1998), Trichinella spp.…”

Section: Introductionmentioning

confidence: 99%

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Neutrophil and eosinophil chemotactic factors in the excretory/secretory products of sheep abomasal nematode parasites

2011

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Both eosinophil chemotactic factor (ECF) and neutrophil chemotactic factor (NCF) activities were demonstrated in excretory/secretory (ES) products and homogenates of Haemonchus contortus and Teladorsagia circumcincta larvae and adult worms in a modified checkerboard assay using a micro-chemotaxis chamber. Neutrophil chemotaxis was seen in 28 of 35 experiments and eosinophil chemotaxis in 20 of 38 experiments. Chemokinetic activity for neutrophils and eosinophils (accounting for 40-50% of total cell migration) was also apparent in only three parasite products for each cell type. Significant NCF activity was present in six of seven adult worm ES products (three of four from T. circumcincta and in all three from H. contortus) and ECF activity in four of five adult ES products, whereas fewer L3 incubates, particularly of T. circumcincta, contained chemotactic activity. All parasite homogenates, with one exception for ECF, were chemotactic for both neutrophils and eosinophils. The sequential use of cellulose ultrafiltration membranes of decreasing pore size did not identify precisely the molecular weight of the NCF and ECF but indicated that the active chemicals were greater than 10 kDa and probably greater than 30 kDa.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Neutrophil and eosinophil chemotactic factors in the excretory/secretory products of sheep abomasal nematode parasites

2011

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“…ES antigens include some surface molecules and molecules expressed by the parasite following invasion of the host. Molecules which have been identified and shown to be secreted at one time or another, by one or another GI nematode, include enzymes (53,63), an anticoagulant (25), complement binding factors, eosinophil attractant (33) and immunosuppressants. Antibodies induced to these antigens may only act indirectly on the parasite (i.e.…”

Section: Antigens Identified By Infection-induced Antibodiesmentioning

confidence: 99%

Strategies for vaccination against gastro-intestinal nematodes

Smith¹,

Munn²

1990

Rev. Sci. Tech. OIE

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A great diversity of gastro-intestinal nematodes parasitise man and his animals. Each nematode is antigenically highly complex with distinct developmental stages. The parasites occupy a range of niches in the host gut and have a variety of feeding habits. Hosts have evolved only partially successful local immune responses. The host and parasite factors modulating these responses are described.Strategies for vaccination are surveyed. It is argued that the best route to successful vaccines will be to seek parasite immunogens which are not normally seen by the host's immune system in the course of infection. Routes to be followed in identifying and characterising such immunogens are proposed and methods for evaluating and maximising the immune response are surveyed. The success of this strategy is illustrated by reference to an experimental molecular vaccine against Haemonchus contortus. Strategies for the use of vaccines and methods for their production in vitro are reviewed.

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