Other Carcinomas

Sebaceous adenocarcinomas of the major salivary glands: a clinicopathological analysis of 10 cases

“…Furthermore, all cases were consistently negative for PAS after diastase digestion and mucicarmine. Regarding p63, this marker has been suggested to be useful to differentiate muco‐epidermoid carcinoma from sebaceous adenocarcinoma; p63 was negative in the latter and expressed in muco‐epidermoid carcinomas, particularly in the epidermoid component . However, p63 expression has been associated with the degree of tumour differentiation in sebaceous carcinoma of the skin, as it was expressed in immature sebocytes as well as in poorly differentiated carcinoma cells .…”

An extremely rare salivary gland tumor: intraductal carcinoma of the buccal mucosa

“…LGCCCs usually occur in the parotid gland and are characterized by a dominant cribriform structural pattern [5,14,15], a pattern not observed in the patient described here. Differential diagnosis should also include cystadenocarcinoma, a tumor characterized by a complex papillary architecture with infiltrative growth and absence of myoepithelial cells [16]. In our patient, however, p63positive myoepithelial cells were distributed around the epithelial islands.…”

“…In our patient, however, p63positive myoepithelial cells were distributed around the epithelial islands. Many similarities have been observed between breast and salivary malignancies [16]. Histologically, intraductal carcinoma of the salivary glands is characterized by intraductal epithelial proliferation, resembling atypical ductal hyperplasia to high-grade ductal carcinoma in situ of the breast.…”

“…The defining features of intraductal carcinoma of the salivary gland include preservation of preexisting myoepithelial cells around the epithelial units and absence of an invasive component [5,13,18]. Complete excision results in a totally benign clinical course [16]. However, preoperative clinical diagnosis of this entity is impossible because the entire sample is necessary to confirm the absence of local invasion.…”

Analysis of the Clinical Relevance of Histological Classification of Benign Epithelial Salivary Gland Tumours

“…Sebaceous carcinoma is recognised in the 2017 WHO classification and some 50 cases have been reported, for example as the malignant component in carcinoma ex pleomorphic adenoma (CXPA). Most, if not all, of the few cases reported appear to have arisen de novo and not from a pre-existing sebaceous adenoma [25,27]. A recent study of ten new cases of sebaceous adenocarcinoma also supports that they arise de novo as none of the ten reported cases had arisen from a pre-existing sebaceous adenoma [28].…”