Otimização de método cromatográfico para quantificação do herbicida ácido 2,4-Diclorofenoxiacético (2,4-D)

Sbano, Andressa; Ferreira, João Pedro; Peckle, Barbara Alvarenga; MacRae, Andrew R.; Direito, Ida Carolina Neves

doi:10.17648/uezo-ast-v1i2.24

Cited by 6 publications

(5 citation statements)

References 10 publications

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“…The 2,4-dichlorophenoxyacetic acid (2,4-D) herbicide is a synthetic auxin belonging to the group of phenoxyacetic acids developed during World War II with the aim of controlling broadleaf weeds (Sbano et al, 2013). 2,4-D is considered one of the most widely used herbicides in the world due to its low cost, high selectiveness, system-D (not classifiable as to human carcinogenicity) by U.S. Environmental Protection Agency (US EPA) (RED, 2005).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms

et al. 2020

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-2,4-Dichlorophenoxyacetic acid (2,4-D) is one of the most widely used herbicides in the world, but its mutagenic and carcinogenic potential is still controversial. We simulated environmental exposure to 2,4-D, with the objective of evaluating the genotoxic effect of acute and chronic exposure to 2,4-D in rodents. We also evaluated the performance of machine learning algorithms in detecting differences in exposure groups through recognition performed from genotoxic characteristics. In the acute phase, 88 Swiss mice were used, distributed in five groups and exposed to nebulizations at different time intervals (24, 48, 72 and 192 hr). In the chronic phase, 88 Wistar rats were used, distributed in two groups (inhaled and oral) and exposed for six months. Femoral bone marrow cells were collected for a micronucleus test and comet assay. Data were evaluated by pattern recognition algorithms. In acute exposure, medium and high concentrations induced DNA damage in the comet assay, but these concentrations did not increase micronucleated cells. In the chronic exposure, there was an increase in micronuclei and DNA damage in the comet assay in all exposed groups regardless of the exposure route. The data showed a robust pattern of distinction between exposed and nonexposed groups to 2,4-D. Our data showed that both acute inhalation exposure and chronic oral and inhalation exposure to 2,4-D can cause genotoxic effects regardless of concentration. Machine learning showed a clear distinction between the control groups and those exposed to 2,4-D, and the effects of exposure are not concentration-dependent.

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Section: Introductionmentioning

confidence: 99%

Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms

et al. 2020

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“…This difference in the response between the plant models used can be explained by the chemical proximity of the semisynthetic molecule, eugenoxyacetic acid, to the synthetic 2,4-D molecule. Since the 2,4-D herbicide is selective, it inhibits the development of broadleaf plants only (Sbano et al 2013).…”

Section: Macroscopic Parametersmentioning

confidence: 99%

Bioactivity and molecular properties of Phenoxyacetic Acids Derived from Eugenol and Guaiacol compared to the herbicide 2,4-D

Alves

Pinheiro

Fontes

et al. 2021

An. Acad. Bras. Ciênc.

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Herbicides are agrochemicals applied in the control of weeds. With the frequent and repetitive use of these substances, serious problems have been reported.Compounds of natural origin and their derivatives are attractive options to obtain new compounds with herbicidal properties. By aiming to develop compounds with potentiated herbicidal activity, phenoxyacetic acids were synthesized from eugenol and guaiacol. The synthesized compounds were characterized and the herbicidal potential of phenoxyacetic acids and precursors was evaluated through bioassays regarding the germination and initial development of Lactuca sativa and Sorghum bicolor seedlings, with the induction of DNA damage. The induction of changes in the mitotic cycle of meristematic cells of roots of L. sativa was also analyzed. At the concentration of 3 mmol L -1 , phenols and their respective phenoxyacetic acids presented phytotoxic and cytotoxic activities in L. sativa and S. bicolor. Eugenol and guaiacol also presented genotoxic action in L. sativa. The toxic effect of eugenoxyacetic acid was more pronounced in L. sativa than in S. bicolor, similar to the commercial 2,4-D herbicide. Molecular properties of the phenols and their derivatives phenoxyacetic acids were compared with the ones obtained for the herbicide 2,4-D, where it was found a correlation between their molecular properties and bioactivity.

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“…Como estes compostos são herbicidas, são capazes de causar inibição de transporte de elétrons na fotossíntese em plantas de folhas largas (propanil) (TOMLIN, 2007), ou provocar desde o crescimento anormal de tecidos, obstrução do floema, até morte do sistema radicular (2,4-D) (SBANO et al, 2013). Assim, através dessa análise, seria possível analisar se a planta de M. officinalis seria tolerante aos pesticidas e quais concentrações seriam utilizadas para o desenvolvimento do processo de fitorremediação.…”

Section: Sensibilidades Das Mudas De M Officinalis Aos Pesticidasunclassified

Fitorremediação Dos Herbicidas 2,4-Diclorofenoxiacético E Propanil Em Solo Cultivado Por Erva Cidreira (Melissa Officinalis)

Piaia

Zago

Denardin³

et al. 2016

CeN

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Resumo O uso frequente ou incorreto de pesticidas pode acarretar em contaminações no solo, águas e alimentos. Para evitar tais contaminações o presente estudo avaliou o potencial de fitorremediação da Melissa officinalis em solo contendo uma mistura dos pesticidas comerciais Aminol e Herbipropanin (2,4-D e propanil Palavras-chave: Fitorremediação; Melissa officinalis; 2,4-D; Propanil. Abstract Frequent or misuse of pesticides can result in contamination of the soil, water and food. To avoid such contamination the present study evaluated the potential of Melissa officinalis in soil phytoremediation containing a mixture of commercial pesticides Aminol and Herbipropanin (2,

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Otimização de método cromatográfico para quantificação do herbicida ácido 2,4-Diclorofenoxiacético (2,4-D)

Cited by 6 publications

References 10 publications

Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms

Evaluation of genotoxicity after acute and chronic exposure to 2,4-dichlorophenoxyacetic acid herbicide (2,4-D) in rodents using machine learning algorithms

Bioactivity and molecular properties of Phenoxyacetic Acids Derived from Eugenol and Guaiacol compared to the herbicide 2,4-D

Fitorremediação Dos Herbicidas 2,4-Diclorofenoxiacético E Propanil Em Solo Cultivado Por Erva Cidreira (Melissa Officinalis)

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