Otitis media with effusion: A possible role for Helicobacter pylori?

Fancy, Tanya; Mathers, Peter H.; Ramadan, Hassan H.

doi:10.1016/j.otohns.2008.11.023

Cited by 21 publications

(16 citation statements)

References 4 publications

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“…8,9 Similar to our study Fancy et al confirmed the presence of H. pylori in the nasopharynx and middle ear space, but Ozcan et al was unable to detect the presence of H. pylori in the middle ear effusions and adenoid specimens of children with 'chronic otitis media with effusion'. 10,11 There were relatively important findings by Iriz et al found presence of H. pylori tested in all tympanosclerosis biopsies, and by Yazdi et al that auditory recovery in GERD positive patients was significantly lower, even six months after surgery and thus suggesting evaluation for GERD an important procedure before tympanoplasty. 12,13 Regurgitation and heartburn have been reported to be other common features of GERD along with pathologic acid flux.…”

Section: Discussionmentioning

confidence: 99%

Vertigo in association with gastro-esophageal reflux disease

Gupta¹,

Gupta

2021

Int J Otorhinolaryngol Head Neck Surg

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Background: Gastroesophageal reflux (GERD) is a condition which develops when the reflux of stomach contents cause troublesome symptoms. Symptoms of GERD are either esophageal: heartburn and regurgitation, or extra-esophageal: chronic cough, recurrent sinusitis, and globus sensation in the throat. One of the extra-esophageal manifestations of GERD is otitis media with effusion, very common among children. The aim of our study was to find the prevalence of GERD and Helicobacter Pylori (H. Pylori) among patients with peripheral vertigo.Methods: The present descriptive study was conducted on randomly selected patients attending outpatient department (OPD) of in community health center, Chenani for a period of one year from August 2018 to July 2019. Patients were selected without the pathology of central nervous system for the further analysis. Results: 85 (75.89%) patients had gastro-esophageal reflux disease. Tendency of GERD was found higher among females (54.12%). Positive H. pylorus was found for 21 patients (24.71%). 65 (74.71%) patients with vertigo positive had GERD. When acid refluxes into the upper GI system, it can affect the tubes that lead to the inner ear. When these tubes become irritated, swelling can occur, causing a loss of balance and common with GERD that occurs when lying down after a meal.Conclusions: It present data confirms the hypothesis that one of the peripheral vertigo causes could be GERD, by way of a mechanism which may include reflux of gastric acids causing inflammation or local infection. The present study found a definite prevalence of GERD and H. Pylori among patients with peripheral vertigo.

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Section: Discussionmentioning

confidence: 99%

Vertigo in association with gastro-esophageal reflux disease

Gupta¹,

Gupta

2021

Int J Otorhinolaryngol Head Neck Surg

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“…Iriz et al ( 26 ) showed that there are similar risk factors, such as increased homocysteine levels, between coronary artery atherosclerosis and tympanosclerosis. Although tympanosclerosis and atherosclerosis are two separate pathologies, they have similar histological and pathophysiologic elements and the same genetic reason has been proposed for both ( 2 ). Ameriso et al ( 30 ) studied evidence concerning the development of inflammation caused by H. Pylori in 38 patients with atherosclerotic plaques who had undergone endarterectomy and found that in most of these patients H. Pylori was correlated to the inflammation, which indicated the correlation between H. Pylori and atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

“…Helicobacter pylori is a Gram-negative, spiral and microaerophilic microorganism that was first isolated from the stomach of patients afflicted with peptic ulcer ( 1 , 2 ). This bacterium can cause gastritis and peptic ulcer in the short-term and carcinoma of the stomach in the long-term ( 3 , 4 ).…”

Section: Introductionmentioning

confidence: 99%

Correlation Between Tympanosclerosis and Helicobacter pylori

Saki

Jahani

Samarbaf

et al. 2015

Jundishapur J Microbiol

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Background:Tympanosclerosis is a condition caused by calcification of tissues in the middle ear mucosa that sometimes results hearing loss. Helicobacter pylori is one of the pathological and etiologic factors in the development of tympanosclerosis.Objectives:The purpose of this study was to show the role of H. pylori in the different aspects of chronic suppurative otitis media using the polymerase chain reaction (PCR) technique.Patients and Methods:This case-control and cross-sectional study was performed on all patients with chronic otitis media, candidates for surgical operations, in 2013. They were allocated into the case group with tympanosclerosis and the control group without tympanosclerosis. During the surgical operation, biopsy was done from middle ear and the samples were studied to see if they contained H. pylori using the PCR method.Results:From a total of 19 patients with tympanosclerosis , 16 cases (84.2%) were H. pylori positive, while in the control group 15 (45.4%) cases out of the 37 cases were H. pylori positive, which showed a significant difference (P = 0.002). Age and gender of the patients, ear dryness and perforation size were not correlated with the presence or absence of H. pylori.Conclusions:There is a significant correlation between tympanosclerosis and H. pylori (P = 0.002). This correlation can single out H. pylori as a pathological factor in the development of tympanosclerosis; however, further studies are needed to prove this correlation.

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“…Then 20 studies were further excluded by the inclusion criteria, including 10 case series studies, 6 animal experiment studies, 3 studies that lacked original data, and 1 duplicate study. Ultimately, a total of 11 case-control studies in 9 different articles [11][12][13][14][15][16][17][18][19] were included in our current meta-analysis. The progress of the literature search is shown in Figure 1.…”

Section: Literature Searchmentioning

confidence: 99%

Association Between Helicobacter pylori Infection and Otitis Media With Effusion Risk in Children: A Systematic Review and Meta‐analysis

Zheng

Gao

et al. 2020

Otolaryngol.--head neck surg.

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Objective To investigate the potential correlation between Helicobacter pylori infection and otitis media with effusion (OME) risk in children. Data Sources Electronic databases were searched, including Cochrane Library, PubMed, Embase, China Biology Medicine disc, China Science and Technology Journal Database, Wanfang Database, and China National Knowledge Infrastructure Database. Review Methods A systematic review and meta-analysis were conducted with Revman 5.3 software. Combined odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate infection-disease association. Results In total, 11 studies from 9 articles regarding H pylori infection and OME risk were enrolled in this meta-analysis. A significant association between H pylori infection and OME was detected for both adenoid samples from the case group (OR, 2.75; 95% CI, 1.43-5.30; P = .002) and middle ear fluid samples from the case group (OR, 4.45; 95% CI, 2.52-7.88; P < .00001). Subgroup analyses suggested a stronger correlation in African and Asian populations. Conclusion This study indicated the correlation between H pylori infection and increased risk of OME in children, especially in African and Asian populations. Further well-designed studies regarding the white population are strongly recommended in the future.

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Otitis media with effusion: A possible role for Helicobacter pylori?

Abstract: The current study confirms the presence of Helicobacter pylori in the nasopharynx and middle ear space, but our results do not support a role for this bacterium in the pathogenesis of otitis media with effusion.

Cited by 21 publications

References 4 publications

Vertigo in association with gastro-esophageal reflux disease

Vertigo in association with gastro-esophageal reflux disease

Correlation Between Tympanosclerosis and Helicobacter pylori

Association Between Helicobacter pylori Infection and Otitis Media With Effusion Risk in Children: A Systematic Review and Meta‐analysis

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