Otostegia persica extraction on healing process of burn wounds

Abstract

PURPOSE:To investigate if the methanolic extract of the Otostegia persica can accelerating healing process of burn wound because of its anti-inflammatory and antioxidant effects. METHODS:Forty eight male Wistar rats were randomized into three study groups of 16 rats each. Burn wounds were created on dorsal part of shaved rats using a metal rod. In group I the burn wound was left without any treatment. Group was treated with topical silver sulfadiazine pomade. In group III, ointment containing the OP extract was administered. Skin biopsies were harvested from burn area on the 3rd, 5th, 14th and 21st days after burn and examined histologically. RESULTS:Re-epithelialization in the control group and in group II was lower than in group III. Re-epithelialization in groups II and III was significantly different from that in the control group. On the 5th day of the experiment, we assessed lower inflammation in the burn area compared to control group. This means that the inflammation was suppressed by methanolic extract of OP. From day 5 to 14; the fibroblast proliferation peaked and was associated with increased collagen accumulation. It was obvious that angiogenesis improved more in the groups II and III, which facilitated re-epithelialisation. CONCLUSION:Methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats. OP is an effective treatment for saving the burn site.

Labdane-Type Diterpenes from the Aerial Parts of Rydingia persica: Their Absolute Configurations and Protective Effects on LPS-Induced Inflammation in Keratinocytes

“…It may be concluded that the aerial parts of R. persica are a rich source of labdane-type diterpenoids with anti-inflammatory and potential wound-healing activity in keratinocytes, thus supporting the traditional application of this plant for the treatment of inflammation and wounds. 14 , 15 …”

The effects of low level laser therapy on Staphylococcus aureus infected third-degree burns in diabetic rats

“…After the anesthesia, the dorsal hair of the rats' right thoracic region was shaved and cleaned with povidone-iodine. Third-degree burns were induced using a metal rod (2 cm diameter) heated to 80-85°C which was exposed for 20s 17 . After the burning procedure, the drug nalbuphine hydrochloride (2 mg/kg) was administered at 12-h intervals for two consecutive days for analgesic prophylaxis.…”

Evaluation of a topical herbal patch for soft tissue wound healing: an animal study

“…An animal study (Ganjali et al. 2013) investigated if the methanolic extract of the Otostegia persica can accelerate the healing process of burn wound because of its anti‐inflammatory and antioxidant effects. It was concluded that methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats.…”

“…Degree of epi-thelialization, number of blood vessels, proliferating cells and collagen deposition are the most generally evaluated parameters to demonstrate positive effects on wound healing. An animal study (Ganjali et al 2013) investigated if the methanolic extract of the Otostegia persica can accelerate the healing process of burn wound because of its antiinflammatory and antioxidant effects. It was concluded that methanolic extract of Otostegia persica exhibited significant healing activity when topically applied on rats.…”