Otosyphilis: a cause of hearing loss in adults with HIV

Pasricha, Janet M; Read, Tim; Street, Alan

doi:10.5694/j.1326-5377.2010.tb03975.x

Cited by 16 publications

(13 citation statements)

References 4 publications

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“…We observed that research studies on hearing loss in children with HIV/AIDS prioritize the detection of hearing losses or reporting the patients' otologic and/or auditory manifestations without associating these with the possible factors that trigger them (2,10,14,15,26,27) . The opportunistic infections that can cause hearing losses are many, but the majority of studies report cases only to demonstrate the patients' clinical situation in relation to hearing loss (26,28,29) .…”

Section: Discussionmentioning

confidence: 99%

Hearing loss in children with HIV/AIDS

Buriti

Oliveira

Muniz

2013

CoDAS

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There were hearing alterations in children with HIV/AIDS analyzed in this study. Discreet hearing losses were the most occurring. We verified statistically significant associations with the use of antiretroviral therapy and otitis. Therefore, we point out the importance of auditory monitoring and intervention as soon as possible, thus favoring adequate development in language and decreasing possible difficulties in learning and social inclusion.

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Section: Discussionmentioning

confidence: 99%

Hearing loss in children with HIV/AIDS

Buriti

Oliveira

Muniz

2013

CoDAS

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“…Otosyphilis can occur at any stage of the disease, and it is suggested that patients with syphilis be routinely evaluated for otologic symptoms [4]. If not diagnosed early, otosyphilis may cause irreversible hearing loss and further progression of the disease [5].…”

Section: Introductionmentioning

confidence: 99%

Otosyphilis with Clinical and Serologic Responses with Weekly Intramuscular Penicillin: A Case Report and Literature Review

Etemady-Deylamy

Abate

2022

Case Reports in Infectious Diseases

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With the increasing prevalence of syphilis in different parts of the world, it is important to be cognizant of serious forms of syphilis. Otosyphilis is a rare form of syphilis with an extremely high rate of complications. Early diagnosis is essential to prevent a complete loss of hearing and decrease mortality. We present a unique case of otosyphilis who presented with left hearing loss, tinnitus, and vertigo, with audiometric findings confirming the hearing loss. An MRI brain showed asymmetric enhancement of the left cochlea and vestibular apparatus. She initially received oral steroids and trans-tympanic steroid injections with transient improvement of symptoms. She was diagnosed with syphilis through contact tracing after her ex-boyfriend tested positive. She received three weekly doses of intramuscular penicillin. Interestingly, her symptoms, rapid plasma regain (RPR) titer, and audiometry findings markedly improved. Once a diagnosis of otosyphilis was established, she received 14 days of intravenous penicillin.

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“…9 However, the serum Venereal Disease Research Laboratory (VDRL) was nonreactive or weakly reactive in 27.1%, and the median titer was 1:2, suggesting that most patients did not have active syphilis. Subsequent case reports describe bilateral or unilateral hearing loss, 10–13 that may be sudden in onset, 12,14 often in persons living with HIV (PLWH), 11–13 sometimes with concomitant ocular syphilis. 12,14–17 A recent series of 12 patients with syphilis and hearing loss who underwent formal audiometry found that the most common presentation was bilateral, asymmetric, mild or moderate high frequency sensorineural hearing loss.…”

Section: Introductionmentioning

confidence: 99%

“…18 Residual hearing loss after otosyphilis treatment is often reported. 10–13 Here we report results of portable audiometry in 329 individuals enrolled in a study of CSF abnormalities in active syphilis, 33 of whom had hearing loss and were reexamined after otosyphilis treatment.…”

Section: Introductionmentioning

confidence: 99%

Hearing loss in individuals at risk for neurosyphilis

et al. 2020

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Otosyphilis is a serious complication of syphilis. 329 participants enrolled in a study of cerebrospinal fluid (CSF) abnormalities in syphilis underwent portable audiometry (250 Hz to 8000 Hz at 5–75 dB); it was repeated in 33 after otosyphilis treatment. Treponema pallidum spp pallidum ( T. pallidum) DNA in blood was quantitated by polymerase chain reaction. Odds ratios (ORs) or hazard ratios (HRs) with 95% confidence intervals (CIs) were determined by logistic, ordinal or Cox regression. 166 (50.5%) had normal hearing; 15 (4.6%) had low frequency (LF) loss alone, 93 (28.3%) had high frequency (HF) loss alone, and 55 (16.7%) had both. Adjusted odds of any hearing loss were higher with detectable blood T. pallidum DNA (3.00 [1.58–5.69], p = 0.001), CSF pleocytosis (2.02 [1.12–3.66], p = 0.02), and older age (2.22 per 10-year increase, [1.70–2.91], p < 0.001). HRs of normalization of LF and HF loss were lower for older individuals (0.20 [0.07–0.63, p = 0.005] and 0.22 [0.05–0.94, p = 0.04]), and HRs for normalization of HF loss were lower for those with more severe loss (0.09 [0.02–0.43], p = 0.002), and in those with CSF pleocytosis (0.32 [0.11–0.96], p = 0.04). Older age and CSF pleocytosis increase the likelihood of otosyphilis and impair hearing recovery after otosyphilis treatment.

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Otosyphilis: a cause of hearing loss in adults with HIV

Cited by 16 publications

References 4 publications

Hearing loss in children with HIV/AIDS

Hearing loss in children with HIV/AIDS

Otosyphilis with Clinical and Serologic Responses with Weekly Intramuscular Penicillin: A Case Report and Literature Review

Hearing loss in individuals at risk for neurosyphilis

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