Animal Models and Experimental Research in Medicine 2023
DOI: 10.5772/intechopen.106858
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Our Clear-Cut Improvement to the Impact of Mouse and Rat Models in the Research Involving Female Reproduction

Abstract: In most research involving female reproductive function, female animals particularly mice and rats are usually employed. This may perhaps be due to their well-defined reproductive cycle (estrous cycle) as well as the ability to breed and handle them easily. The short and precise length of estrus cycle usually 4–5 days make mice models the choicest mammal when it comes to human related research. Also, they possess very short reproductive age typically 7–8 months reaching sexual maturity at weeks 4–7 following t… Show more

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Cited by 2 publications
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“…While the morphology of human and mouse reproductive systems are distinctive (e.g., the mouse has a bicornuate uterus compared to the human single uterus), their reproductive cycles are very similar [ 64 ]. Indeed, similarly to humans, the mouse reproductive cycle oscillates periodically via fluctuations in progesterone and estrogen concentrations, which shows that mice models are suitable for answering certain reproductive research questions [ 64 ]. In order to increase translatability, a xenograft study could be performed, transplanting human ovarian tissue into immune-deficient mice.…”
Section: Discussionmentioning
confidence: 99%
“…While the morphology of human and mouse reproductive systems are distinctive (e.g., the mouse has a bicornuate uterus compared to the human single uterus), their reproductive cycles are very similar [ 64 ]. Indeed, similarly to humans, the mouse reproductive cycle oscillates periodically via fluctuations in progesterone and estrogen concentrations, which shows that mice models are suitable for answering certain reproductive research questions [ 64 ]. In order to increase translatability, a xenograft study could be performed, transplanting human ovarian tissue into immune-deficient mice.…”
Section: Discussionmentioning
confidence: 99%