The article is devoted to the analysis of cross-border cooperation in the Great Altai, or the Altai Interregion, which unites six administrative subject of four states, within the framework of the International Coordinating Council "Our Common Home -Altai," which have been established and functioning for sixteen years. The paper concludes that interregional integration helps the border areas of the Altai region to more effectively solve pressing development problems, more actively attract representatives of business, academic and creative groups, and expand the range of partnerships.