Our Experience with Perfluorohexyloctane (F<sub>6</sub>H<sub>8</sub>) as a Temporary Endotamponade in Vitreoretinal Surgery

Stefaniotou, Maria; Aspiotis, Miltiadis; Kitsos, Georgios; Kalogeropoulos, Chr D; Asproudis, Ioannis; Psilas, K

doi:10.1177/112067210201200612

Cited by 32 publications

(36 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…F6H8 was the first PFA that was used as a long-term heavy tamponade in several clinical trials (Table 1). [11][12][13][14][15][16] It was left intraocularly up to 14 weeks; on average, F6H8 was removed around 8 weeks postoperatively (Table 1). Marked differences in the complications and results of individual cases within one series 15,16 as well between different series have been reported.…”

Section: Partially Fluorinated Alkanes and Alkenesmentioning

confidence: 99%

“…9,10 The next substance in use as a long-term heavy tamponade, one which achieved certification in Europe for several clinical studies in the early 2000s was perfluorohexyloctane (F6H8). While some authors found encouraging results, 11,12 other groups reported a plethora of complications and discouraged the use of F6H8 as a vitreous substitute. [13][14][15][16] Around the same time, two new tamponades showed promising results in initial experimental settings, OL62HV and O62, only too soon to be associated with a high failure rate and massive complications.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

117

125

View full text Add to dashboard Cite

Background Heavier than water intraocular tamponades have several theoretical advantages over conventional tamponades, especially in the treatment of complicated retinal detachments and proliferative viteroretinopathy of the lower fundus periphery. However, initial clinical series of various heavy tamponades have reported significant complication rates. Therefore, heavy tamponades have not found widespread acceptance. Three recently developed heavy silicone oil tamponades, Oxane HD, Densiron 68, and HWS 46-3000, are much better tolerated and presently seem to enter routine clinical practice. Materials and methods Literature review of 21 publications on the clinical application of 9 different heavy tamponades (fluorosilicone, C10F18, F6H8, OL62HV, Oxane HD, O62, F6H8-silicone oil mixture, Densiron 68, and HWS 46-3000). Results The first generation (fluorinated silicone and perfluorocarbon liquids) and second generation (partially fluorinated alkanes) of heavy tamponades were associated with relatively high complication rates, for example, tamponade emulsification, intraocular inflammation, and rise in intraocular pressure. The complication spectrum of the new generation of heavy silicone oils (Oxane HD, Densiron 68, and HWS 46-3000) seems to be comparable to conventional silicone oil tamponades while providing better support for the inferior retina and the posterior pole. Conclusion The recently developed heavy silicone oil tamponades are safe and effective tools for the use of complicated retinal detachments of the inferior fundus.

show abstract

Section: Partially Fluorinated Alkanes and Alkenesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heavy tamponade 1: a review of indications, use, and complications

Heimann

Stappler

Wong

2008

Eye

117

125

View full text Add to dashboard Cite

show abstract

“…This is one of the main concerns because the dispersion reduces the volume of the tamponade agent, thus reducing the contact with the surface of the retina. 26,37,38 Hydrofluorocarbon oligomers, produced by joining two to four FALK molecules, have been developed to increase oligomer viscosity and to minimize dispersion. The OL62HV oligomer has a viscosity of 1750 mPa.s.…”

Section: Eyementioning

confidence: 99%

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Tognetto

Lepori

Lapasin

et al. 2008

Eye

View full text Add to dashboard Cite

Aim To study the solubility of perfluorohexyloctane (F6H8) in silicone oil (polydimethylsiloxane (PDMS) 1000) and to measure the viscosity and the specific gravity of the mixture obtained (heavy silicone oil or HSO tamponade) to define the ideal ratio of these components. Methods The solubility diagram of the mixture was obtained with the turbidimetric method, indicating the miscibility of F6H8 and silicone oil 1000 at all the useful temperatures. The viscosity was measured in steady shear conditions by using a controlled stress rheometer (Haake RS150) and a double cone/plate (DC 60/4) system, both at 25 and 371C for different volume per cent compositions of the mixture. The specific gravity was measured at 371C using a digital densimeter. Results A mixture of F6H8 30 v% and PDMS 70 v% was found to be transparent and stable at all the useful temperatures. By combining these proportions of the two substances, a resultant density of 1.06 g/cm 3 was obtained. The viscosity of the 30% F6H8 mixture was 203 mPa.s at 251C and 163 mPa.s at 371C respectively. Conclusions The ideal F6H8 and silicone oil mixture can be obtained combining 30% of F6H8 with 70% of silicone oil 1000. This mixture seems to have rheological properties useful for its use as an alternative intraocular heavy tamponade.

show abstract

“…Desta forma pôde ser avaliado o possível efeito de substâncias liberadas pelo F 6 H 8 que poderiam estar presentes no meio de cultura. O teste de citotoxici-dade indireta e obtenção dos extratos foi delineado de acordo com recomendações internacionais (21) .…”

Section: Teste De Citotoxicidade Indiretaunclassified

“…Estudos com o perfluorohexiloctano como substituto do vítreo em olhos de coelhos não mostrou alterações retinianas importantes na microscopia ótica e eletrônica (19) e a experiência clínica com o F 6 H 8 , embora limitada, mostra respostas distintas quanto ao dano retiniano e resposta inflamatória, conforme diferentes trabalhos (20)(21)(22) . Apesar desses achados iniciais, e devido ao fato do F 6 H 8 ser um produto novo, estudos referentes a citotoxicidade desse composto são necessá-rios para comprovar a sua segurança.…”

Section: Introductionunclassified

Avaliação do possível efeito tóxico de um alcano semifluorinado de uso oftalmológico sobre cultura de células Vero

Estacia¹,

Santos²,

Genari³

2004

Arq. Bras. Oftalmol.

View full text Add to dashboard Cite

Avaliação do possível efeito tóxico de um alcano semifluorinado de uso oftalmológico sobre cultura de células Vero Objetivos: Perfluorocarbonos líquidos (PFCLs) são usados em cirurgias oftalmológicas de vítreo-retina. Os PFCLs podem causar reações inflamató-rias, danos celulares e destruição da arquitetura normal da retina. Na tentativa de se evitar estes efeitos, foram desenvolvidos os alcanos semifluorinados (ASF). Este trabalho avaliou o uso potencial de um ASF, o perfluorohexiloctano (F 6 H 8 ), como substituto do vítreo de longo prazo em condições controladas por meio de cultura celular. Métodos: Foi feita análise da citotoxicidade indireta, na qual as células entram em contato apenas com elementos solúveis que pudessem ser eliminados pelo perfluorohexiloctano. Avaliou-se então a toxicidade direta, ou seja, a toxicidade mediada pelo contato, do perfluorohexiloctano por meio de microscopia eletrônica de varredura e a imunocitoquímica para a actina. Utilizou-se como controle, células em meio de cultura livre de qualquer tratamento, um controle positivo para toxicidade, que apresenta comprovado efeito tóxico às células, e um controle de peso que exercesse compressão mecânica similar à quantidade de perfluorohexiloctano utilizada no experimento. Resultado: Observou-se que o referido produto não apresenta toxicidade indireta. Os ensaios de toxicidade direta mostraram que as alterações celulares promovidas pelo perfluorohexiloctano eram similares àquelas exercidas pelo controle de peso e distintas do controle de toxicidade. Conclusões: O perfluorohexiloctano não apresenta toxicidade indireta e tem efeito mais compressivo do que tóxico sobre as células em cultura. RESUMODescritores: Fluorocarbonetos/toxicidade; Cultura de células; Procedimentos cirúrgicos oftalmológicos INTRODUÇÃOAs cirurgias oftalmológicas vítreo-retinianas tiveram grande desenvolvimento com a técnica da vitrectomia, que possibilitou ampla substituição do gel vítreo e manipulação da retina, fornecendo uma opção de tratamento eficiente para reaplicar a retina ao seu leito normal, permitindo manter sua nutrição e capacidade funcional. Este objetivo nem sempre é fácil de ser conseguido, devido ao processo de proliferação fibrosa e conseqüente tração que tende a manter a retina descolada.O uso dos perfluorocarbonos líquidos (PFCLs) há alguns anos na oftalmologia como ferramenta para devolver a retina a sua posição anatômica de maneira menos traumática, facilitou grandemente a cirurgia de vítreo-retina. A

show abstract

Our Experience with Perfluorohexyloctane (F₆H₈) as a Temporary Endotamponade in Vitreoretinal Surgery

Abstract: F6H8 seems to be a promising tamponade agent for special cases of RD.

Cited by 32 publications

References 11 publications

Heavy tamponade 1: a review of indications, use, and complications

Heavy tamponade 1: a review of indications, use, and complications

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Avaliação do possível efeito tóxico de um alcano semifluorinado de uso oftalmológico sobre cultura de células Vero

Contact Info

Product

Resources

About

Our Experience with Perfluorohexyloctane (F6H8) as a Temporary Endotamponade in Vitreoretinal Surgery

Abstract: F6H8 seems to be a promising tamponade agent for special cases of RD.

Cited by 32 publications

References 11 publications

Heavy tamponade 1: a review of indications, use, and complications

Heavy tamponade 1: a review of indications, use, and complications

A new heavy internal tamponade in vitreoretinal surgery: an in vitro study

Avaliação do possível efeito tóxico de um alcano semifluorinado de uso oftalmológico sobre cultura de células Vero

Contact Info

Product

Resources

About

Our Experience with Perfluorohexyloctane (F₆H₈) as a Temporary Endotamponade in Vitreoretinal Surgery