Out-of-hospital cardiac arrest: in-hospital intervention strategies

Hassager, Christian; Nagao, Ken; Hildick‐Smith, David

doi:10.1016/s0140-6736(18)30315-5

Cited by 101 publications

(90 citation statements)

References 84 publications

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“…Furthermore, the use of a nasogastric tube to administer ticagrelor can contribute to the contrary results . This phenomenon was explained to be a result of pharmacokinetic changes occurring at lower temperatures and stem from an impaired gastrointestinal tract with reflux, decreased gastrointestinal motility, and absorption dysfunction . Kander et al .…”

Section: Th and P2y12 Inhibitorsmentioning

confidence: 99%

“…The idea of TH is to inhibit temperature-mediated reperfusion injury and improve long-term neurological outcome among OHCA survivors. 40 The numerous medications administered to extremely ill patients in the intensive care unit require strict pharmacokinetic and pharmacodynamic monitoring to provide appropriate drug safety and efficacy. Although TH significantly affects numerous aspects of physiology, multiple mechanisms have been proposed to explain its influence on the drug metabolism.…”

Section: Th and Drug Metabolismmentioning

confidence: 99%

“…29 This phenomenon was explained to be a result of pharmacokinetic changes occurring at lower temperatures and stem from an impaired gastrointestinal tract with reflux, decreased gastrointestinal motility, and absorption dysfunction. 39,40 Kander et al 28,63 evaluated different platelet function tests (Multiplate and Sonoclot viscoelasticity) and aimed to analyze the relation between gastric emptying and flow cytometry-based VASP in CA survivors treated under mild hypothermic conditions for 24 hours receiving LD of ticagrelor 0-4 hours before target temperature was achieved. It was evaluated at hypothermia and normothermia with Multiplate and Sonoclot analyses.…”

Section: Prasugrel and Thmentioning

confidence: 99%

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Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review

Eyileten

Pordzik

Siller-Matula

et al. 2019

Clin Pharma and Therapeutics

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Out‐of‐hospital cardiac arrest is among the most frequent causes of death worldwide. Immediate intervention, as well as dual antiplatelet therapy consisting of acetylsalicylic acid and a P2Y12 inhibitor is often recommended. In line with the growing number of reports on cardiac arrest treatment, therapeutic hypothermia (TH) has been proposed for unconscious patients to improve neurological outcomes. Nevertheless, studies report controversial and often discrepant results on the effect of hypothermia on blood coagulability and platelet reactivity. In this review, we summarize the knowledge on platelet function under diverse hypothermic conditions. Additionally, we review the current literature on the effect of systemic hypothermia on pharmacokinetic and pharmacodynamic properties of antiplatelet agents. It has been shown that TH can alter the effectiveness of antiplatelet agents, including P2Y12 inhibitors, through multiple mechanisms, hence, special attention should be paid while implementing antiplatelet therapy in patients under TH conditions.

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Section: Th and P2y12 Inhibitorsmentioning

confidence: 99%

Section: Th and Drug Metabolismmentioning

confidence: 99%

Section: Prasugrel and Thmentioning

confidence: 99%

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Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review

Eyileten

Pordzik

Siller-Matula

et al. 2019

Clin Pharma and Therapeutics

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“…Current international guidelines recommend using NSE to assess neurological outcomes [5,6], as NSE is a marker of ischemic brain injury [7]. NSE is found in neuronal and neuroendocrine cells, and serum NSE concentrations correlate positively with the extent of anoxic-ischemic neurological injury and with malignant electroencephalography changes, after cardiac arrest [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Prognostic Abilities of Serial Neuron-Specific Enolase and Lactate and their Combination in Cardiac Arrest Survivors During Targeted Temperature Management

Ryoo

Sohn

Kim

et al. 2020

JCM

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This study aimed to determine the prognostic ability of serial neuron-specific enolase (NSE) and lactate in cardiac arrest survivors treated with targeted temperature management (TTM) and to investigate whether a combination of NSE and lactate could increase prognostic information. This observational, retrospective, cohort study was conducted between January 2013 and December 2018; data were extracted from an out-of-hospital cardiac arrest registry. We collected serial serum NSE and lactate levels during TTM. The primary endpoint was poor neurological outcome at 28 days from cardiac arrest. Of all 160 included patients, 98 (61.3%) had poor neurological outcomes. Areas under the curves (AUCs) for NSE were 0.797, 0.871, and 0.843 at 24, 48, and 72 h, respectively (all p < 0.05). AUCs for lactate were 0.669, 0.578, 0.634, and 0.620 at 0, 24, 48, and 72 h, respectively (all p < 0.05). Although the combination of initial lactate and NSE at 48 h yielded the highest discovered AUC (0.877) it was not statistically different from that for the 48 h NSE alone (p = 0.692). During the TTM, NSE at 48 h from cardiac arrest was the most robust prognostic marker in comatose cardiac arrest survivors. However, a combination of the 48 h NSE with lactate did not increase the prognostic information.

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“…Out-of-hospital cardiac arrest (OHCA) is a significant public health problem worldwide [1]. In Japan, over 127,000 OHCAs occur annually and one-month survival rates remain low despite improvements in healthcare, including public education, emergency medical systems, and integrated post-cardiac arrest care [2][3][4]. Thorough efforts have been undertaken to improve patient outcomes [5].…”

Section: Introductionmentioning

confidence: 99%

Geographical Differences and the National Meeting Effect in Patients with Out-of-Hospital Cardiac Arrests: A JCS–ReSS Study Report

Yumoto

Naito

Yorifuji

et al. 2019

IJERPH

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The “national meeting effect” refers to worse patient outcomes when medical professionals attend academic meetings and hospitals have reduced staffing. The aim of this study was to examine differences in outcomes of patients with out-of-hospital cardiac arrest (OHCA) admitted during, before, and after meeting days according to meeting location and considering regional variation of outcomes, which has not been investigated in previous studies. Using data from a nationwide, prospective, population-based, observational study in Japan, we analyzed adult OHCA patients who underwent resuscitation attempts between 2011 and 2015. Favorable one-month neurological outcomes were compared among patients admitted during the relevant annual meeting dates of three national scientific societies, those admitted on identical days the week before, and those one week after the meeting dates. We developed a multivariate logistic regression model after adjusting for confounding factors, including meeting location and regional variation (better vs. worse outcome areas), using the “during meeting days” group as the reference. A total of 40,849 patients were included in the study, with 14,490, 13,518, and 12,841 patients hospitalized during, before, and after meeting days, respectively. The rates of favorable neurological outcomes during, before, and after meeting days was 1.7, 1.6, and 1.8%, respectively. After adjusting for covariates, favorable neurological outcomes did not differ among the three groups (adjusted OR (95% CI) of the before and after meeting dates groups was 1.03 (0.83–1.28) and 1.01 (0.81–1.26), respectively. The “national meeting effect” did not exist in OHCA patients in Japan, even after comparing data during, before, and after meeting dates and considering meeting location and regional variation.

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Out-of-hospital cardiac arrest: in-hospital intervention strategies

Cited by 101 publications

References 84 publications

Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review

Effectiveness of Antiplatelet Drugs Under Therapeutic Hypothermia: A Comprehensive Review

Prognostic Abilities of Serial Neuron-Specific Enolase and Lactate and their Combination in Cardiac Arrest Survivors During Targeted Temperature Management

Geographical Differences and the National Meeting Effect in Patients with Out-of-Hospital Cardiac Arrests: A JCS–ReSS Study Report

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