Out-patient TB care in Kazakhstan

Sadykova, Laura; Berikova, Elmira; Kurakbayev, Kural; Maimakov, Talgat

doi:10.20534/elbls-17-1-43-48

Cited by 1 publication

(3 citation statements)

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“…The yield of product 4 is 28.7 %; melting point is 156-157 °C. 1 H NMR spectrum, δ, ppm: (J, Hz): 2.49 s (4H, H-11ax, 11eq, 12ax, 12eq), 7.34 d (2H, H-3, 5, 3 J 4.8), 8.71 d (2H, H-2, 6, 3 J 4.8), 9.37 c (1H, H-9). 13…”

Section: Methodsmentioning

confidence: 99%

“…The yield of product 6 is 32 %, melting point is 220-221 °C. 1 H NMR spectrum, δ, ppm: (J, Hz): 7.85 d (2H, H-3, 5, 3 J 5.0), 8.82 d (2H, H-2, 6, 3 J 6.0), 7.92-7.95 m (2H, H-13, 14), 7.97-8.00 m (2H, H-12, 15), 11.72 br. s (1H, H-8).…”

Section: N-(13-dioxoisoindoline-2-yl)isonicotinamide (6)mentioning

confidence: 99%

“…Over the past decade, tuberculosis has once again become one of the leading causes of death in the world; at least three million people die from tuberculosis in the world every year [1,2]. The urgency of the problem of tuberculosis incidence is associated with the spread of drug-resistant strains of the causative agent of tuberculosis, therefore there is a constant need to find new means to combat diseases caused by resistant pathological strains to improve human life.…”

Section: Introductionmentioning

confidence: 99%

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Interaction of Isonicotinic Acid Hydrazide with Carboxylic Acid Anhydrides

Нуркенов¹,

Фазылов²,

Сейлханов³

et al. 2023

Eurasian J. Chem.

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There has been presented data on the synthesis of monoamides and cyclic imides which are derivatives of isonicotinic acid hydrazide. Cyclic anhydrides of carboxylic acids (succinic, maleic and phthalic) easily react with the hydrazide of isonicotinic acid with cycle opening, forming isonicotinoylhydrazide of dicarboxylic acids, and under more severe conditions the latter are transformed into cyclic acid imides. The structures of the synthesized compounds were studied using 1H- and 13C-NMR spectroscopy, as well as data from twodimensional COSY (1H-1H) and HMQC (1H-13C) spectra. The values of chemical shifts, multiplicity and integral intensity of 1H and 13C signals in one-dimensional NMR spectra were determined. Homo- and heteronuclear interactions confirming the structure of the studied compounds were established using spectra in the COSY (1H-1H) and HMQC (1H-13C) formats. In the approximation of the density functional B3LYP with a base set of 6-31G(d), the enthalpy of the reactions ΔHr in the absence and in the presence of a solvent — isopropanol (self-consistent reaction field method) were calculated quantum-chemically.

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Section: Methodsmentioning

confidence: 99%

Section: N-(13-dioxoisoindoline-2-yl)isonicotinamide (6)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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