Outbreak of bovine tuberculosis featuring anergy to the skin test, udder lesions and milkborne disease in young calves

Houlihan, M. G.; Dixon, F.; Page, Nicola

doi:10.1136/vr.163.12.357

Cited by 21 publications

(14 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our findings are consistent with previous studies [45,49,52,53]. The risk associated with increasing age likely reflects longer exposure time to the bTB infected cattle [5,54].…”

Section: Districtsupporting

confidence: 93%

Bovine tuberculosis prevalence and risk factors in selected districts of Bangladesh

et al. 2020

View full text Add to dashboard Cite

A cross-sectional survey was conducted in selected districts of Bangladesh to estimate the prevalence of bovine tuberculosis (bTB), and to identify the risk factors for bTB. We included 1865 farmed cattle from 79 herds randomly selected from five districts. Herd and animal level data were collected using semi-structured interviews with cattle herd owners. The single intradermal comparative tuberculin test (SICTT) was used to estimate the prevalence of bTB. The risk factors were identified using mixed-effect multiple logistic regression analyses. The overall herd and animal level prevalences of bTB were estimated to be 45.6% (95% Confidence Interval [CI] = 34.3–57.2%) and 11.3 (95% CI = 9.9–12.8%), respectively, using the OIE recommended >4 mm cut-off. The true animal level prevalence of bTB was estimated to be 11.8 (95% Credible Interval = 2.1–20.3%). At the herd level, farm size, bTB history of the farm and type of husbandry were significantly associated with bTB status in univariable analysis. Similarly, age group, sex, pregnancy status and parity were significantly associated with bTB at cattle level. However, in multivariable analysis only herd size at the herd level and age group and pregnancy status at the cattle level were significant. Compared to a herd size of 1–10, the odds of bTB were 22.8 (95% CI: 5.2–100.9) and 45.6 times (95% CI: 5.0–417.7) greater in herd sizes of >20–50 and >50, respectively. The odds of bTB were 2.2 (95% CI: 1.0–4.5) and 2.5 times (95% CI: 1.1–5.4) higher in cattle aged >3–6 years and > 6 years, compared to cattle aged ≤1 year. Pregnancy increased the odds of bTB by 1.7 times (95% CI: 1.2–2.4) compared to non-pregnant cattle. Taken together, the results suggest high herd and animal level prevalence of bTB in these 5 districts, with the greatest risk of bTB in older and pregnant cattle within large herds (>20), and highlight an urgent need for continued surveillance and implementation of bTB control programs in Bangladesh.

show abstract

“…Our findings are consistent with previous studies [45,49,52,53]. The risk associated with increasing age likely reflects longer exposure time to the bTB infected cattle [5,54].…”

Section: Districtsupporting

confidence: 93%

Bovine tuberculosis prevalence and risk factors in selected districts of Bangladesh

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A similar decline in the IFN‐ γ response has been observed in experimentally infected badgers and wild boar ( Sus scrofa ); in both cases associated with seroconversion and progressive clinical disease. Possible explanations for these observed reductions include a shift from a T‐helper type 1‐biased response to a T helper type 0‐biased response, as observed in experimentally infected cattle, and/or progressive anergy in response to continued antigenic stimulation; anergy to tuberculin skin tests (indirect measures of the cell‐mediated response) has been reported in cattle, and in humans …”

Section: Discussionmentioning

confidence: 92%

Association of quantitative interferon‐γ responses with the progression of naturally acquired Mycobacterium bovis infection in wild European badgers (Meles meles)

et al. 2015

View full text Add to dashboard Cite

SummaryBovine tuberculosis is one of the biggest challenges facing cattle farming in Great Britain. European badgers (Meles meles) are a reservoir host for the causal agent, Mycobacterium bovis. There have been significant recent advances in diagnostic testing for tuberculosis in humans, cattle and badgers, with the development of species-specific assays for interferon-c (IFNc), an important cytokine in tuberculous infections. Using data collected from longitudinal studies of naturally infected wild badgers, we report that the magnitude of the IFN-c response to M. bovis antigens at the disclosing test event was positively correlated with subsequent progression of disease to a seropositive or excreting state. In addition, we show that the magnitude of the IFN-c response, despite fluctuation, declined with time after the disclosing event for all badgers, but remained significantly higher in those animals with evidence of disease progression. We discuss how our findings may be related to the immunopathogenesis of natural M. bovis infection in badgers.

show abstract

“…Several other factors such as variation in the level of prevalence, breed of cattle involved, and the age distribution may also affect this trend. For example, it is not uncommon that chronically infected animals with severe pathology are unresponsive for the SICCT test (20,41). On the other hand, animals at early stage of infection tend to show optimal skin reaction but with fewer and less severe pathology (Supplementary Table 1).…”

Section: Discussionmentioning

confidence: 99%

Genotype Diversity of Mycobacterium bovis and Pathology of Bovine Tuberculosis in Selected Emerging Dairy Regions of Ethiopia

et al. 2020

View full text Add to dashboard Cite

Bovine tuberculosis (bTB) is endemic in Ethiopia with higher prevalence in cattle, particularly in the central parts. Spread of Mycobacterium bovis (M. bovis) to wider regions is inevitable in uncontrolled conditions. This study was conducted to explore the pathology, characterize M. bovis strains, and describe genotypic diversity to demonstrate possible epidemiological links in emerging dairy areas of Ethiopia, namely, Mekelle and Gondar. Twenty-seven bTB positive cattle identified by the Single Intradermal Comparative Cervical Tuberculin (SICCT) test were subjected to post-mortem inspection to determine lesion distribution and pathological score. Samples from tissues with visible tuberculous or suspected non-visible lesions were processed and cultured following a standard protocol. Isolates identified as M. bovis by Region of Difference (RD)-based Polymerase Chain Reaction (PCR) were also spoligotyped to determine their spoligotype patterns. Post-mortem inspection of visceral organs indicated bTB suggestive lesions in 41% of the animals, with 25% being in the lungs. Lymph nodes from 77% of the animals had lesions. Fifty-five isolates identified from 24 of the slaughtered animals were confirmed as M. bovis. No other mycobacterial species were isolated. Spoligotyping classified strains from 21 of these animals into seven spoligotype patterns: SB0133,

show abstract

Outbreak of bovine tuberculosis featuring anergy to the skin test, udder lesions and milkborne disease in young calves

Cited by 21 publications

References 13 publications

Bovine tuberculosis prevalence and risk factors in selected districts of Bangladesh

Bovine tuberculosis prevalence and risk factors in selected districts of Bangladesh

Association of quantitative interferon‐γ responses with the progression of naturally acquired Mycobacterium bovis infection in wild European badgers (Meles meles)

Genotype Diversity of Mycobacterium bovis and Pathology of Bovine Tuberculosis in Selected Emerging Dairy Regions of Ethiopia

Contact Info

Product

Resources

About