Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 56, China, 2012

Huang, Guohong; Yao, Wenqing; Yu, Wei; Mao, Lingling; Sun, Haibo; Yao, Wei; Jiang, Tian; Zhang, Bo; Zhu, Zhen; Zhang, Yan; Zhao, Zhuo; Xu, Wenbo

doi:10.1371/journal.pone.0110781

Cited by 37 publications

(36 citation statements)

References 16 publications

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“…Another new serotype, HAdV-56, was found to be the causative agent for a large scale of outbreak of epidemic keratoconjunctivitis, with 451 cases in the Dalian City in 2012 [63]. The HAdV-14p1 seems more associated with kids, being isolated from a baby with pneumonia in Beijing and causing an outbreak of febrile respiratory illness in a primary and a middle school in Gansu in 2011, which was the first school-based HAdV-14p1 outbreak in the world [61].…”

Section: S Suis St7 Emerged and Spread In Chinamentioning

confidence: 99%

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Liu

et al. 2018

Front. Med.

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For the past several decades, the infectious disease profile in China has been shifting with rapid developments in social and economic aspects, environment, quality of food, water, housing, and public health infrastructure. Notably, 5 notifiable infectious diseases have been almost eradicated, and the incidence of 18 additional notifiable infectious diseases has been significantly reduced. Unexpectedly, the incidence of over 10 notifiable infectious diseases, including HIV, brucellosis, syphilis, and dengue fever, has been increasing. Nevertheless, frequent infectious disease outbreaks/events have been reported almost every year, and imported infectious diseases have increased since 2015. New pathogens and over 100 new genotypes or serotypes of known pathogens have been identified. Some infectious diseases seem to be exacerbated by various factors, including rapid urbanization, large numbers of migrant workers, changes in climate, ecology, and policies, such as returning farmland to forests. This review summarizes the current experiences and lessons from China in managing emerging and re-emerging infectious diseases, especially the effects of ecology, climate, and behavior, which should have merits in helping other countries to control and prevent infectious diseases.

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Section: S Suis St7 Emerged and Spread In Chinamentioning

confidence: 99%

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Liu

et al. 2018

Front. Med.

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“…8 Ads are obligate intracellular pathogens that are fully dependent on the cellular replication machinery. [11][12][13] Common symptoms are keratitis, conjunctivitis, edema, pain, lacrimation, formation of pseudomembranes and decreased vision. The acyclic nucleoside analogue cidofovir has been shown effective against EKC-causing Ads.…”

Section: Introductionmentioning

confidence: 99%

Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells

et al. 2015

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Adenovirus type 37 (Ad37) is one of the principal agents responsible for epidemic keratoconjunctivitis (EKC), a severe ocular infection that remains without any available treatment. Recently, a trivalent sialic acid derivative (ME0322, Angew. Chem. Int. Ed., 2011, 50, 6519) was shown to function as a highly potent inhibitor of Ad37, efficiently preventing the attachment of the virion to the host cells and subsequent infection. Here, new trivalent sialic acid derivatives were designed, synthesized and their inhibitory properties against Ad37 infection of the human corneal epithelial cells were investigated. In comparison to ME0322, the best compound (17a) was found to be over three orders of magnitude more potent in a cell-attachment assay (IC50 = 1.4 nM) and about 140 times more potent in a cell-infection assay (IC50 = 2.9 nM). X-ray crystallographic analysis demonstrated a trivalent binding mode of all compounds to the Ad37 fiber knob. For the most potent compound ophthalmic toxicity in rabbits was investigated and it was concluded that repeated eye administration did not cause any adverse effects.

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“…Classically the primary EKC causing adenoviruses have been HAdV-D8( 40–42 ), 37( 42–44 ), and 64( 42, 45 ) (previously classified as 19a( 46 )). More recently other species D adenovirus have been associated with EKC, including HAdV-D53(previously classified as HAdV-D22/H8)( 47, 48 ), 54( 49 ), 56( 50 ).…”

Section: Introductionmentioning

confidence: 99%

Adenovirus serotype 26 utilises sialic acid bearing glycans as a primary cell entry receptor

Baker

Mundy

Davies

et al. 2019

Preprint

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Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 56, China, 2012

Cited by 37 publications

References 16 publications

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Landscape of emerging and re-emerging infectious diseases in China: impact of ecology, climate, and behavior

Triazole linker-based trivalent sialic acid inhibitors of adenovirus type 37 infection of human corneal epithelial cells

Adenovirus serotype 26 utilises sialic acid bearing glycans as a primary cell entry receptor

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