Outbreak of monensin poisoning in cattle

Wardrope, DD; Macleod, N. S. M.; Sloan, JR

doi:10.1136/vr.112.24.560

Cited by 14 publications

(13 citation statements)

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“…As características clínicas e patológicas da intoxicação por monensina presentes nos bubalinos desse experimento foram semelhantes às encontradas em relatos anteriores de intoxicação espontânea e experimental por monensina na espécie bovina (Collins & McCrea 1978, Wardrope et al 1983, Potter et al 1984, Schweitzer et al 1984, Geor & Robinson 1985, Galitzer et al 1986, Shlosberg et al 1986, Basaraba et al 1999, Gonzalez et al 2005. Dos 7 bubalinos dosados nesse experimento, 6 desenvolveram sinais clínicos característicos de intoxicação por monensina tais como apatia, anorexia, diarréia, dificuldade de locomoção, dispnéia e morte.…”

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“…Os sinais clínicos relacionados com distúrbios digestivos foram anorexia, diarréia e sialorréia. A anorexia foi observada em todos os bubalinos e é um dos sinais clínicos mais frequentemente descritos na intoxicação por ionóforos em bovinos (Collins & McCrea 1978, Wardrope et al 1983, Potter et al 1984, Schweitzer et al 1984, Geor & Robinson 1985, Hosie & Rollo 1985, Shlosberg et al1986, Basaraba et al 1999, Gabor & Downing 2003, Gonzalez et al 2005. A anorexia é provavelmente associada com a indução de algum tipo de informação sensorial como o sabor da monensina, ou com o mal estar resultante das alterações produzidas na fermentação ruminal (Shlosberg et al 1986).…”

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“…Lesões semelhantes ocorreram nos músculos esqueléticos de 4 dos 5 bubalinos necropsiados, mas foi pronunciada em apenas 1 desses (Búfalo A). Essa distribuição das lesões de necropsia é semelhante à descrita anteriormente em intoxicações de bovinos por antibióticos ionóforos ( , Wardrope et al 1983, Schweitzer et al 1984, Galitzer et al 1986, Shlosberg et al 1986, Shlosberg et al 1992, Basaraba et al 1999. Achados clínicos e patológicos característicos de insuficiência cardíaca estiveram associados com lesões microscópicas importantes no miocárdio de 3 bubalinos.…”

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Intoxicação experimental por monensina em búfalos e bovinos

et al. 2007

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Sinais clínicos e lesões característicos de intoxicação por monensina foram induzidos em búfalos dosados (1 dia) com 15, 10, 7,5 e 5mg/kg de monensina. Apenas os búfalos dosados com 2,5 (1 dia) e 1 mg/kg (7 dias) de monensina não morreram. Os sinais clínicos iniciaram cerca de 6 h após dosagem com monensina e incluíram apatia, anorexia, diarréia, sialorréia, fraqueza muscular, taquicardia, dificuldade locomotora, dispnéia, distensão da jugular, decúbito e morte. As dosagens de creatinina quinase (CK) dos búfalos aumentaram acentuadamente após dosagem com monensina. As alterações macroscópicas foram ascite, hidrotórax, hidropericárdio, cardiomegalia, hepatomegalia e áreas pálidas focais no miocárdio e nos músculos esqueléticos. Degeneração e necrose de miofibras foram os principais achados histopatológicos. Por outro lado, nenhuma evidência de doença, nem mesmo alteração nos níveis de CK, foram observados nos bovinos dosados com as mesmas dosagens de monensina, confirmando observações preliminares que esses animais são mais resistentes à monensina que os búfalos.

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Intoxicação experimental por monensina em búfalos e bovinos

et al. 2007

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“…47 In 2004, the FDA approved use of monensin in total mixed rations for increased milk production efficiency in dairy cattle; the following year, ionophores were widely approved for use in dairy cattle. 48 Intoxications occur as a result of error in the amount of ionophore added to the diet, 49 inaccurate on-farm feeding, 50 administration to the wrong cohort, or exposure of cattle not acclimated to the ionophore-containing ration. 51 With no established LD 50 for cattle, toxic monensin concentrations range between 21.9 mg/kg and 80 mg/kg of bodyweight.…”

Section: Feed-related Toxicantsmentioning

confidence: 99%

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

Varga¹,

Puschner²

2012

VMRR

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Abstract:In this retrospective study all suspect bovine intoxications submitted to the California Animal Health and Food Safety Laboratory between January 1, 2000 and December 31, 2011 were reviewed. A total of 1199 cases were submitted, but a diagnosis of intoxication was only established in 13.5% of cases. In these cases, overexposures to minerals, metals, and poisonous plants were determined as the most commonly diagnosed poisonings in cattle in California. Nitrate/nitrite poisoning was the most commonly diagnosed plant-associated intoxication, followed by gossypol and oleander. This study details the diagnostic challenges and treatment options for the most commonly diagnosed intoxications. To ensure proper treatment and prevention of new cases, accurate diagnosis is necessary, and therefore this review provides an essential tool for the food animal practitioner. Available toxicological analyses are offered at select laboratories, which can be time consuming and expensive, yet the potential for residues in consumed animal products and implications for human health necessitate testing and consultation. Any potential exposure to a toxicant in cattle should be reviewed to determine whether a residue hazard exists. Therapy focuses on immediate removal of the toxicant from the environment and from the gastrointestinal tract. With few antidotes available, most are cost prohibitive to treat numerous affected cattle. In addition, most antidotes will require extra-label drug use and establishment of meat and milk withdrawal times.

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“…Contrairement aux molécules dont ils sont issus, la cationomycine déacylée et l'acide nigéricique n'ont eu aucun effet sur l'orientation des fermentations dans le rumen. Parmi les composés testés, qui ont présenté une activité &dquo;promoteur de (Raun, 1974) (Durand, 1982;Bergen and Bates, 1984;Schelling, 1984 (Wardrope et al, 1983 (VFA) by gas chromatography (Jouany, 1982). Gas production was determined at 1, 4 and 6 h, the composition of the mixture being determined by gas chromatography (Jouany and Senaud, 1978) (Table IV) Gas production measured after 6 h of incubation was significantly decreased by lonomycin and its L 2 derivative and by nigericin.…”

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In vitro study of the effect of different ionophore antibiotics and of certain derivatives on rumen fermentation and on protein nitrogen degradation

Hillaire

Jouany²,

Gaboyard³

et al. 1989

Reprod. Nutr. Dévelop.

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Summary -An in vitro study was carried out to evaluate the effect of different ionophore antibiotics and some of their derivatives on rumen fermentation and on the degradation of peanut meal nitrogen. The increase in the production of propionic acid at the expense of acetic acid, observed with lonomycin, nigericin, cationomycin and lysocellin, was identical to that noted with monensin. The decrease in methanogenesis observed in the presence of monensin was also found with cationomycin and lysocellin. With the exception of lysocellin, which greatly reduced protein degradation of peanut meal, and of nigericin, which had no effect on this parameter, the 2 other molecules presented the same action as monensin. The negative effect of monensin on microbial ammonia uptake was demonstrated with the same intensity in the presence of cationomycin; it was slightly higher with nigericin and particularly accentuated with lonomycin and lysocellin. Three ester derivatives of monensin (monensin acetate, monensin propionate and monensin butyrate) had a similar action to that of monensin on the orientation of rumen fermentations. The monensin isobutyrate derivative appeared to be more active than monensin and only weakly altered microbial ammonia uptake. The oxolonomycin and hydroxolonomycin derivatives behaved identically to lonomycin with respect to microbial metabolism and protein nitrogen degradation. Unlike the molecules from which they derive, the deacylated cationomycin and nigericic acid had no effect on the orientation of rumen fermentations. Of the compounds tested and presenting a potential 'growthpromoting action' at least comparable to that of monensin, and which demonstrated lower toxicity on mice, three molecules (oxolonomycin, lysocellin and

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Outbreak of monensin poisoning in cattle

Cited by 14 publications

References 0 publications

Intoxicação experimental por monensina em búfalos e bovinos

Intoxicação experimental por monensina em búfalos e bovinos

Retrospective study of cattle poisonings in California: recognition, diagnosis, and treatment

In vitro study of the effect of different ionophore antibiotics and of certain derivatives on rumen fermentation and on protein nitrogen degradation

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