Outbreak of Seoul virus among rats and rat owners — United States and Canada, 2017

Kerins, Janna L.; Koske, Sarah E; Kazmierczak, James J.; Austin, Connie; Gowdy, K; Dibernardo, Antonia

doi:10.14745/ccdr.v44i02a07

Cited by 14 publications

(15 citation statements)

References 5 publications

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“…However, mild and atypical clinical presentations are a constant feature of SEOV-induced HFRS forms, as repeatedly shown hereunder [1]. A family member later developed similar symptoms, but was not hospitalized [2]. In late December, 2016, a report of mild AKI followed in an 18-year-old female from Tennessee (USA) (hematuria and peak serum creatinine level of 1.27 mg/dL).…”

Section: Preludementioning

confidence: 63%

“…A total of 24/183 (13.1%) US or Canadian residents associated with these facilities were found to be serologically SEOV-positive, resulting in three hospitalizations in the USA. No AKI was mentioned, and spontaneous recovery occurred, whereas no serious illness was reported from Canada [2]. Similar cases, with or without AKI, and all induced by apparently healthy pet rats, were described in the UK [5,6] and in France [7].…”

Section: Preludementioning

confidence: 86%

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Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited

Clément¹,

LeDuc

Lloyd

et al. 2019

Viruses

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Recent reports from Europe and the USA described Seoul orthohantavirus infection in pet rats and their breeders/owners, suggesting the potential emergence of a “new” public health problem. Wild and laboratory rat-induced Seoul infections have, however, been described since the early eighties, due to the omnipresence of the rodent reservoir, the brown rat Rattus norvegicus. Recent studies showed no fundamental differences between the pathogenicity and phylogeny of pet rat-induced Seoul orthohantaviruses and their formerly described wild or laboratory rat counterparts. The paucity of diagnosed Seoul virus-induced disease in the West is in striking contrast to the thousands of cases recorded since the 1980s in the Far East, particularly in China. This review of four continents (Asia, Europe, America, and Africa) puts this “emerging infection” into a historical perspective, concluding there is an urgent need for greater medical awareness of Seoul virus-induced human pathology in many parts of the world. Given the mostly milder and atypical clinical presentation, sometimes even with preserved normal kidney function, the importance of simple but repeated urine examination is stressed, since initial but transient proteinuria and microhematuria are rarely lacking.

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Section: Preludementioning

confidence: 63%

Section: Preludementioning

confidence: 86%

Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited

Clément¹,

LeDuc

Lloyd

et al. 2019

Viruses

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“…In 2008, the first locally acquired case of HFRS caused by the SEOV was confirmed. In 2017, the US CDC investigated an outbreak of SEOV infection that has infected 17 rat owners in seven states (Kerins et al, 2018). The number of hantavirus cases by year in different states is summarized in Figure 2.…”

Section: The Re-emergence Of Hantavirusmentioning

confidence: 99%

“…In Canada, HCPS is still very rare, but cases are recorded every year and show seasonal patterns, mainly between March and May and between September and November. A total of 64 cases have been confirmed since 2000, of which 12 were reported in 2013, most in western Canadian provinces such as Alberta, Manitoba, British Columbia, and Saskatchewan (Kerins et al, 2018). SNV and ANDV are responsible for the majority of hantavirus cases leading to HCPS.…”

Section: The Re-emergence Of Hantavirusmentioning

confidence: 99%

Vaccines and Therapeutics Against Hantaviruses

Liu

et al. 2020

Front. Microbiol.

103

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Hantaviruses (HVs) are rodent-transmitted viruses that can cause hantavirus cardiopulmonary syndrome (HCPS) in the Americas and hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Together, these viruses have annually caused approximately 200,000 human infections worldwide in recent years, with a case fatality rate of 5-15% for HFRS and up to 40% for HCPS. There is currently no effective treatment available for either HFRS or HCPS. Only whole virus inactivated vaccines against HTNV or SEOV are licensed for use in the Republic of Korea and China, but the protective efficacies of these vaccines are uncertain. To a large extent, the immune correlates of protection against hantavirus are not known. In this review, we summarized the epidemiology, virology, and pathogenesis of four HFRS-causing viruses, HTNV, SEOV, PUUV, and DOBV, and two HCPS-causing viruses, ANDV and SNV, and then discussed the existing knowledge on vaccines and therapeutics against these diseases. We think that this information will shed light on the rational development of new vaccines and treatments.

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“…50 In 2017, outbreaks of SEOV infections occurred in several states of US. 51 This indicated that SEOV infections might be underdiagnosed, especially by the physicians outside of Asia. In the Netherlands, until very recently, a human case of SEOV infection has been reported.…”

mentioning

confidence: 99%

Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

Ling

Verner-Carlsson

Eriksson

et al. 2019

Journal of Medical Virology

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Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belgium, and human cases of SEOV infection have been reported in Germany, UK, France, and Belgium. In the search of hantaviruses in brown rats from the Netherlands, we found both serological and genetic evidence for the presence of SEOV in the local wild rat population. To further decipher the relationship with other SEOV variants globally, the complete genome of SEOV in the Netherlands was recovered. SEOV sequences obtained from three positive rats (captured at close trapping locations at the same time) were found highly similar. Phylogenetic analyses demonstrated that two lineages of SEOV circulate in Europe. Strains from the Netherlands and UK, together with the Baxter strain from US, constitute one of these two, while the second includes strains from Europe and Asia. Our results support a hypothesis of diverse routes of SEOV spread into Europe. These findings, combined with other indications on the expansion of the spatial European range of SEOV, suggest an increased risk of this virus for the public health, highlighting the need for increased surveillance.

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Outbreak of Seoul virus among rats and rat owners — United States and Canada, 2017

Cited by 14 publications

References 5 publications

Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited

Wild Rats, Laboratory Rats, Pet Rats: Global Seoul Hantavirus Disease Revisited

Vaccines and Therapeutics Against Hantaviruses

Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe

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