Outbreak of Severe<i>Pseudomonas aeruginosa</i>Infections Caused by a Contaminated Drain in a Whirlpool Bathtub

Berrouane, Y.; McNutt, Louise‐Anne; Buschelman, Barry J.; Rhomberg, Paul R.; Sanford, M. D.; Hollis, Richard J.; Pfaller, Michael A.; Herwaldt, Loreen A.

doi:10.1086/317501

Cited by 92 publications

(50 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A total of 427 environmental samples were obtained and genotyped with a median number of eight samples per patient (mean (range) samples 8.5 (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)). Nurses were asked to collect a minimum of four samples per home, with at least one sample from the kitchen, bathroom, toilet and the patient's nebuliser.…”

Section: Resultsmentioning

confidence: 99%

“…P. aeruginosa has been recovered from environmental sources in both in-and outpatient healthcare settings, e.g. sinks, tap water in a paediatric ward [16], toys, baths, hand soaps [17], pulmonary function equipment, hospital drains [18], whirlpool baths [19], dental equipment [20], and the hands of healthcare workers and CF patients [16][17][18]. The possibility of environment-to-patient transmission of these strains has been studied by DORING et al [16], who described the possibility of environment-to-patient transmission of P. aeruginosa in a hospital setting.…”

Section: Resultsmentioning

confidence: 99%

“…In contrast to the extensive studies on the presence of P. aeruginosa in the hospital environment [16][17][18][19][20][22][23][24] and on patient-to-patient transmission, there are only a few reports on the prevalence of P. aeruginosa in the home environment of both CF and non-CF patients (table 3) [22,[25][26][27][28]. These studies provide conflicting results.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Pseudomonas aeruginosain the home environment of newly infected cystic fibrosis patients

Schelstraete¹,

Daele²,

Boeck³

et al. 2007

Eur Respir J

View full text Add to dashboard Cite

The source of acquisition of Pseudomonas aeruginosa in cystic fibrosis (CF) patients remains unknown. Patient-to-patient transmission has been well documented but the role of the environment as a source of initial infection is as yet unclear.In the present study, the origin of the first P. aeruginosa isolate in CF patients was investigated by comparing the P. aeruginosa genotype(s) from newly infected patients with genotypes of P. aeruginosa isolates from the home environment and from other patients from the same CF centre.A total of 50 newly infected patients were studied. P. aeruginosa could be cultured from 5.9% of the environmental samples, corresponding to 18 patients. For nine of these, the genotype of the environmental P. aeruginosa isolate was identical to the patient's isolate. In total, 72% of the environmental P. aeruginosa isolates were encountered in the bathroom. Patient-to-patient transmission within the CF centre could not be ruled out for three patients.In summary, a low prevalence of Pseudomonas aeruginosa was found in the home environment of the newly infected cystic fibrosis patients. The bathroom should be targeted in any preventive cleaning procedures. An environmental source of the new infection could not be ruled out in nine patients.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Pseudomonas aeruginosain the home environment of newly infected cystic fibrosis patients

Schelstraete¹,

Daele²,

Boeck³

et al. 2007

Eur Respir J

View full text Add to dashboard Cite

show abstract

“…Other potential sources of P. aeruginosa include whirlpools, hot tubs (16,65), swimming pools, or dental equipment, but none of these sources have been linked conclusively to acquisition by patients with CF. In contrast, adequately chlorinated swimming pools do not harbor P. aeruginosa (65,77).…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

Infection Control in Cystic Fibrosis

2004

View full text Add to dashboard Cite

Over the past 20 years there has been a greater interest in infection control in cystic fibrosis (CF) as patient-to-patient transmission of pathogens has been increasingly demonstrated in this unique patient population. The CF Foundation sponsored a consensus conference to craft recommendations for infection control practices for CF care providers. This review provides a summary of the literature addressing infection control in CF. Burkholderia cepacia complex, Pseudomonas aeruginosa, and Staphylococcus aureus have all been shown to spread between patients with CF. Standard precautions, transmission-based precautions including contact and droplet precautions, appropriate hand hygiene for health care workers, patients, and their families, and care of respiratory tract equipment to prevent the transmission of infectious agents serve as the foundations of infection control and prevent the acquisition of potential pathogens by patients with CF. The respiratory secretions of all CF patients potentially harbor clinically and epidemiologically important microorganisms, even if they have not yet been detected in cultures from the respiratory tract. CF patients should be educated to contain their secretions and maintain a distance of >3 ft from other CF patients to avoid the transmission of potential pathogens, even if culture results are unavailable or negative. To prevent the acquisition of pathogens from respiratory therapy equipment used in health care settings as well as in the home, such equipment should be cleaned and disinfected. It will be critical to measure the dissemination, implementation, and potential impact of these guidelines to monitor changes in practice and reduction in infections

show abstract

“…Like C. albicans, it can be carried in a variety of body locations, and can cause superficial mucosal infections as well as bloodstream infections in compromised hosts (Fidel et al, 1999 ;Pfaller et al, 1998). Its success is particularly worrisome because it is naturally drug resistant (Berrouane et al, 1999 ;Fidel et al, 1999 ;Hazen, 1995 ;Pfaller et al, 1999 ;Sanglard et al, 1999Sanglard et al, , 2001). Epidemiologically, the success of C. glabrata mimics that of C. albicans (Odds, 1988) and for that reason one might expect it to possess similar virulence traits.…”

Section: Introductionmentioning

confidence: 99%

Phenotypic switching and filamentation in Candida glabrata

et al. 2002

View full text Add to dashboard Cite

Candida glabrata switches spontaneously, reversibly and at high frequency among the following four phenotypes distinguishable by graded colony colouration on CuSO 4 -containing agar : white (Wh), light brown (LB), dark brown (DB) and very dark brown (vDB). These phenotypes also differ in a graded fashion in the level of expression of the metallothionein gene MTII (Wh T LB T DB a vDB), the frequency of switching (Wh S LB S DB S vDB) and colouration on phloxine B-containing agar (Wh S LB S DB S vDB). Switching among the four graded phenotypes is referred to as ' the core switching system '. An additional switch phenotype, ' irregular wrinkle ' (IWr), has been identified, which exhibits a highly wrinkled colony morphology. The characteristics of IWr suggest that switching to and from this phenotype represents a second high-frequency switching system. A microscopic analysis revealed that during the first 3 days of colony development, cells in the centres of Wh, LB, DB and vDB colonies expressed almost exclusively the budding yeast phenotype. After 3 days, however, pseudohyphae and cells extending tubes accumulated, so that by 7 days the proportions of these two cellular phenotypes reached 40-50 % and 10-20 %, respectively. In contrast, IWr colonies were composed almost exclusively of pseudohyphae through the first 6 days of colony development. After 6 days, IWr colonies began to accumulate both budding yeast cells and tubes. The tubes formed by C. glabrata reached lengths of up to six cell diameters, but the tubes did not represent traditional compartmentalized hyphae. Tube growth ended when the tube tip expanded to form a bud. Tubes then functioned as corridors for daughter nucleus migration to the apical bud, and were ultimately left uncompartmentalized and nucleus free. Core switching, pseudohypha formation and tube formation occurred in a majority of 62 tested clinical isolates, demonstrating that these developmental programmes are general characteristics of most strains of C. glabrata.

show abstract

Outbreak of SeverePseudomonas aeruginosaInfections Caused by a Contaminated Drain in a Whirlpool Bathtub

Cited by 92 publications

References 29 publications

Pseudomonas aeruginosain the home environment of newly infected cystic fibrosis patients

Pseudomonas aeruginosain the home environment of newly infected cystic fibrosis patients

Infection Control in Cystic Fibrosis

Phenotypic switching and filamentation in Candida glabrata

Contact Info

Product

Resources

About