Outcome after severe accidental hypothermia in the French Alps: A 10-year review

Debaty, Guillaume; Moustapha, Ibrahim; Bouzat, Pierre; Maignan, Maxime; Blancher, Marc; Rallo, A; Brun, Julien; Chavanon, Olivier; Danel, Vincent; Carpentier, F.; Payen, Jean François; Briot, Raphaël

doi:10.1016/j.resuscitation.2015.06.013

Cited by 78 publications

(60 citation statements)

References 31 publications

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“…The use of ECMO in severe hypothermia is a recognised life-saving procedure. This has been confirmed by studies from other countries as well as from our Centre [9][10][11][12]. However, an adequate model of funding and suitable administrative solutions are relevant factors affecting therapeutic decisions.…”

Section: Discussionsupporting

confidence: 61%

Difficulties in funding of VA-ECMO therapy for patients with severe accidental hypothermia

Kosiński¹,

Darocha²,

Jarosz³

et al. 2017

Anaesthesiol Intensive Ther

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Section: Discussionsupporting

confidence: 61%

Difficulties in funding of VA-ECMO therapy for patients with severe accidental hypothermia

Kosiński¹,

Darocha²,

Jarosz³

et al. 2017

Anaesthesiol Intensive Ther

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“…The second suggests that hypothermia inhibits the enzymatic activities involved in the coagulation cascade . Indeed, case studies show that hypothermia induces both a hypercoagulable state and a hemorrhagic tendency . Thus, it remains unclear whether hypothermia enhances or inhibits coagulation.…”

Section: Introductionmentioning

confidence: 99%

Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model

Horioka

Tanaka

Isozaki

et al. 2019

Journal of Thrombosis and Haemostasis

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BackgroundHypothermia, either therapeutically induced or accidental (ie, an involuntary decrease in core body temperature to <35°C), results in hemostatic disorders. However, it remains unclear whether hypothermia enhances or inhibits coagulation, especially in severe hypothermia. The present study evaluated the thrombocytic and hemostatic changes in hypothermic mice.MethodsC57Bl/6 mice were placed at an ambient temperature of −20°C under general anesthesia. When the rectal temperature decreased to 15°C, 10 mice were immediately euthanized, while another 10 mice were rewarmed, kept in normal conditions for 24 hours, and then euthanized. These treatments were also performed in 20 splenectomized mice.ResultsThe hypothermic mice had adhesion of CD62P‐positive platelets with high expression of von Willebrand factor (vWF) in their spleens, while the status of the peripheral platelets was unchanged. Furthermore, the plasma levels of platelet factor 4 (PF4) and pro‐platelet basic protein (PPBP), which are biomarkers for platelet degranulation, were significantly higher in hypothermic mice than in control mice, indicating that hypothermia activated the platelets in the splenic pool. Thus, we analyzed these biomarkers in asplenic mice. There was no increase in either PF4 or PPBP in splenectomized hypothermic mice. Additionally, the plasma D‐dimer elevation and microthrombosis were caused in rewarmed mice, but not in asplenic rewarmed mice.ConclusionsOur results indicate that hypothermia leads to platelet activation in the spleen via the upregulation of vWF, and this activation causes hypercoagulability after rewarming.

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“…1,2 It is caused not only by cold environment (mountains), water accidents and winter season, but also by various conditions, such as head trauma, extensive burn injury, endocrine disorders or infectious diseases. [3][4][5][6] Despite the modern supportive care, the in-hospital mortality rate of patients with moderate or severe AH was approximately 40% in the USA, whereas approximately 30% of all hypothermic patients who visited the emergency departments (ED) in Japan died based on a previous study. 7,8 Population aging is a common public health issue in industrialized countries.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and outcomes of accidental hypothermia among elderly patients in Japan: Data from the J‐Point registry

Morita

Matsuyama

Ehara

et al. 2018

Geriatrics Gerontology Int

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Outcome after severe accidental hypothermia in the French Alps: A 10-year review

Cited by 78 publications

References 31 publications

Difficulties in funding of VA-ECMO therapy for patients with severe accidental hypothermia

Difficulties in funding of VA-ECMO therapy for patients with severe accidental hypothermia

Hypothermia‐induced activation of the splenic platelet pool as a risk factor for thrombotic disease in a mouse model

Prevalence and outcomes of accidental hypothermia among elderly patients in Japan: Data from the J‐Point registry

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