Outcome and Determinants of Outcome of COVID-19 Infection Among Hemodialysis Patients: Findings From a National Dialysis Network Program in India

Kakkanattu, Tom Jose; Sankarasubbaiyan, Suresh; Yadav, Ashok; Kundu, Monica; Bg, Mallikarjuna Gowda; Kumar, Vivek; Shah, Kamal D.; Jha, Vivekanand

doi:10.1016/j.ekir.2021.03.003

Cited by 20 publications

(27 citation statements)

References 9 publications

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“…In this study, 261 patients were included, who underwent haemodialysis in our center, and the study included patients on MHD, AKI and Acute on CKD. The most common symptoms at presentation were fever and/or cough as seen in other studies [9][10][11][12][13][14][15][16][17][18].…”

Section: Discussionsupporting

confidence: 62%

“…MHD patients are at increased risk of developing COVID-19 infections as compared to the general population with prevalence ranging from 3 to 9% [14][15][16][17][18]. Sixteen (40%) out of 40 MHD patients succumbed to the illness while mortality in other studies ranged from 19-40% [8][9][10][11][12][13][14][15][16][17][18]. Higher mortality in this study was attributable to a more rapid and severe course of illness.…”

Section: Discussioncontrasting

confidence: 44%

“…Patients on MHD were the most disadvantageous cohort, as accesses to health care facility were limited especially during the lockdown period [5]. There have been few reports providing the outcome of MHD patients but none so far looked into the outcome of all patients including MHD, AKI and acute on CKD who underwent haemodialysis [9][10][11][12][13][14][15][16][17][18].…”

Section: Discussionmentioning

confidence: 99%

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Clinical Profile and Outcome of Haemodialysis in Patients With COVID-19 – A Single Centre Experience

Vardhan¹,

Kumar²,

Shyama³

et al. 2021

Cureus

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IntroductionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing COVID-19 disease is the third coronavirus to have emerged in the last 20 years. The COVID-19 infection causes more severe illness in patients with comorbid diseases, especially in patients with diabetes, hypertension and kidney failure. MethodsThis is a retrospective study using electronic records and laboratory data of adult patients hospitalised at All India Institute of Medical Sciences (AIIMS), Patna between May 1st, 2020 and March 31st, 2021, who were diagnosed with COVID-19 and needed haemodialysis. The demographic characteristics, co-morbidities, symptoms, clinical course, laboratory parameters, and treatments were recorded. The aim of this study is to evaluate the clinical profile and outcome of patients on hemodialysis with COVID-19 infection. ResultsThe study included 261 COVID-19 patients who needed haemodialysis. The most common symptoms on admission were fever (72.8%), cough (64.3%) and dyspnoea (46.6%). The mean age was 58.4 +/-15 years. A total of 195 patients (74.7%) were male. The most common co-morbid condition was hypertension (85.1%) followed by diabetes (71.9%). A total of 118 (45.2) patients had acute on chronic kidney disease (CKD), 40 (15.3) were on maintenance haemodialysis (MHD) and 103 (39.5) were having acute kidney injury (AKI). Eight patients were renal transplant recipients. At presentation, 183 (70.1%) patients were having mild to moderately severe infection and 78 (29.9%) patients were having severe disease. A total of 213 patients required ICU admissions, 186 (75.3%) of whom required invasive ventilation. Overall mortality was 66% (172/261) and the rest were discharged. ConclusionThe study suggests that COVID-19 disease has a significantly more severe course and poorer outcome in patients requiring haemodialysis.

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Section: Discussionsupporting

confidence: 62%

Section: Discussioncontrasting

confidence: 44%

Section: Discussionmentioning

confidence: 99%

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Clinical Profile and Outcome of Haemodialysis in Patients With COVID-19 – A Single Centre Experience

Vardhan¹,

Kumar²,

Shyama³

et al. 2021

Cureus

View full text Add to dashboard Cite

show abstract

“…The mortality during the second wave was higher than that during the corresponding period (15 march-15 June) in the first wave (2020) and the pre-COVID period (2019) [ Fig 1 ]. 1 Diabetes, older age and need for hospitalization were associated with mortality in adjusted models. Individuals who had received even one dose of the vaccine had 33% reduced risk of being infected with the virus and 46% (95% confidence interval 17-62%) lower risk of mortality in adjusted models even after being diagnosed with COVID-19.…”

mentioning

confidence: 98%

“…Patients getting in-centre hemodialysis (HD) have been disproportionately affected by Covid-19 infection. 1 , 2 India has seen two waves of SARS-Cov2 infection in 2020 and 2021, with the second wave being more intense.…”

mentioning

confidence: 99%