Outcome and predictors of mortality in patients requiring invasive mechanical ventilation due to acute respiratory failure while undergoing ambulatory chemotherapy for solid cancers

Park, So Young; Lim, So Yeon; Um, Sung Hee; Koh, Won Jung; Chung, Man Pyo; Kim, Hojoong; Kwon, O Jung; Park, Hye Kyeong; Kim, Seok Jin; Im, Young Hyuck; Ahn, Myung Ju; Suh, Gee Young

doi:10.1007/s00520-012-1709-z

Cited by 26 publications

(14 citation statements)

References 38 publications

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“…All studies were published in English (MeSH term of our research). Study populations varied across studies, including four studies focusing on cancer patients [21, 23, 34, 39], fourteen on patients with hematological malignancies, and the remaining on various mixes of these underlying diseases. Outcome variables included ICU mortality in 13 studies, hospital mortality in 24 studies, and 6-month mortality in a single study.…”

Section: Resultsmentioning

confidence: 99%

Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH)

et al. 2016

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PURPOSEWhether neutropenia has an impact on the mortality of critically ill cancer patients remains controversial, yet it is widely used as an admission criterion and prognostic factor.METHODSSystematic review and meta-analysis. Studies on adult cancer patients and intensive care units were searched on PubMed and Cochrane databases (2005-2015). Summary estimates of mortality risk differences were calculated using the random-effects model.RESULTSAmong the 1,528 citations identified, 38 studies reporting on 6,054 patients (2,097 neutropenic patients) were included. Median mortality across the studies was 54% [45–64], with unadjusted mortality in neutropenic and non-neutropenic critically ill patients of 60% [53–74] and 47% [41–68], respectively. Overall, neutropenia was associated with a 10% increased mortality risk (6%-14%; I2 = 50%). The admission period was not associated with how neutropenia affected mortality. Mortality significantly dropped throughout the study decade [−11% (−13.5 to −8.4)]. This mortality drop was observed in non-neutropenic patients [−12.1% (−15.2 to −9.0)] but not in neutropenic patients [−3.8% (−8.1 to +5.6)].Sensitivity analyses disclosed no differences in underlying malignancy, mechanical ventilation use, or Granulocyte-colony stimulating factor use. Seven studies allowed the adjustment of severity results (1,350 patients). Although pooled risk difference estimates were similar to non-adjusted results, there was no significant impact of neutropenia on mortality (risk difference of mortality, 9%; 95% CI, −15 to +33)CONCLUSIONAlthough the unadjusted mortality of neutropenic patients was 11% higher, this effect disappeared when adjusted for severity. Therefore, when cancer patients become critically ill, neutropenia cannot be considered as a decision-making criterion.

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Section: Resultsmentioning

confidence: 99%

Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH)

et al. 2016

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“…This finding is compatible with most of the other researches. 28,29 Namendys et al reported IMV not to be associated with increased ICU mortality in ST patients but this study included postoperative patients. 26 NIMV is a way of reducing the requirement for IMV.…”

Section: Resultsmentioning

confidence: 90%

Impact of factors at admittance predicting intensive care unit mortality in critically ill cancer patients

2016

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“…A weakness in our model is that it does not include an assessment of patient performance status (e.g. Eastern Cooperative Oncology Group Performance Scale), which is known to correlate with survival for various malignancies [28]. This is because performance status was rarely available during retrospective review of our electronic medical record for our patient cohort at the time of filter implantation.…”

Section: Discussionmentioning

confidence: 99%

Development of a predictive model for 6 month survival in patients with venous thromboembolism and solid malignancy requiring IVC filter placement

Huang

Odisio

Sabir

et al. 2017

J Thromb Thrombolysis

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Purpose Our purpose was to develop a predictive model for short-term survival (i.e. less than 6 months) following inferior vena cava filter placement in patients with venous thromboembolism (VTE) and solid malignancy. Materials and Methods Clinical and laboratory parameters were retrospectively reviewed for patients with solid malignancy who received a filter between January 2009 and December 2011 at a tertiary care cancer center. Multivariate Cox proportional hazards modeling was used to assess variables associated with 6 month survival following filter placement in patients with VTE and solid malignancy. Significant variables were used to generate a predictive model. Results 397 patients with solid malignancy received a filter during the study period. Three variables were associated with 6 month survival: (1) serum albumin (hazard ratio [HR] 0.496, P<0.0001), (2) recent or planned surgery (<30 days) (HR 0.409, P<0.0001), (3) TNM staging (stage 1 or 2 versus stage 4, HR 0.177, P=0.0001; stage 3 versus stage 4, HR 0.367, P=0.0002). These variables were used to develop a predictive model to estimate 6 month survival with an area under the receiver operating characteristic curve of 0.815, sensitivity of 0.782, and specificity of 0.715. Conclusions Six month survival in patients with VTE and solid malignancy requiring filter placement can be predicted from 3 patient variables. Our predictive model could be used to help physicians decide whether a permanent or retrievable filter may be more appropriate as well as to assess the risks and benefits for filter retrieval within the context of survival longevity in patients with cancer.

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Outcome and predictors of mortality in patients requiring invasive mechanical ventilation due to acute respiratory failure while undergoing ambulatory chemotherapy for solid cancers

Abstract: The outcome of patients with acute respiratory failure needing invasive mechanical ventilation during ambulatory chemotherapy for solid cancer is poor. Prechemotherapy performance status is an independent predictor of mortality.

Cited by 26 publications

References 38 publications

Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH)

Outcomes in adult critically Ill cancer patients with and without neutropenia: a systematic review and meta-analysis of the Groupe de Recherche en Réanimation Respiratoire du patient d'Onco-Hématologie (GRRR-OH)

Impact of factors at admittance predicting intensive care unit mortality in critically ill cancer patients

Development of a predictive model for 6 month survival in patients with venous thromboembolism and solid malignancy requiring IVC filter placement

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