Outcome and prognostic factors of spontaneous ruptured hepatocellular carcinoma treated with transarterial embolization

Shin, Byung Seok; Park, Mi-Hyun; Jeon, Gyeong Sik

doi:10.1258/ar.2010.100369

Cited by 42 publications

(45 citation statements)

References 30 publications

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“…In this context, it is important to determine an algorithm or guidelines for treatment of patients with a ruptured HCC in consideration of their background and current state. The prognosis of an affected patient is thought to be defined by hepatic reserve function prior to the rupture, total bleeding volume, and HCC progression including portal vein tumor thrombosis [14]. In the present study, prognoses differed between the recurrent and naïve cases, as the former showed a tendency of more advanced stage HCC and worse hepatic reserve function, which may influence prognosis.…”

Section: Discussionmentioning

confidence: 66%

Prognosis and therapy for ruptured hepatocellular carcinoma: Problems with staging and treatment strategy

Hiraoka

Kawamura

Aibiki

et al. 2015

European Journal of Radiology

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Section: Discussionmentioning

confidence: 66%

Prognosis and therapy for ruptured hepatocellular carcinoma: Problems with staging and treatment strategy

Hiraoka

Kawamura

Aibiki

et al. 2015

European Journal of Radiology

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“…In cases of unstable states or unresectable tumors (with IDRFs), interventional embolization or laparotomy for hemostasis as damage-control surgery might be considered. Interventional embolization is an effective treatment for tumors originating from organs such as the liver and kidney when spontaneous rupture occurs [17][18][19][20]. However, NB originates from the retroperitoneum and usually has no definitive blood supply.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and risk factors of 47 cases with ruptured neuroblastoma in children

et al. 2020

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Background: Neuroblastoma (NB) tumor rupture is a rare oncology emergency with a poor prognosis. We aimed to evaluate patient clinical characteristics and risk factors for ruptured NB. Methods: A retrospective study of 47 patients with confirmed NB Results: The median age at presentation was 29 months (adrenal and retroperitoneum origin) for 47 ruptured NB patients. Spontaneous tumor rupture occurred in 22 cases; 18 cases occurred during or after the first chemotherapy cycle, and 7 occurred after core needle biopsy. Five patients died of tumor rupture, and 17 patients' parents refused further antitumor therapy. Among the 25 remaining patients, 6 survived without disease, 5 received ongoing treatment and achieved stable disease, and 14 died. According to multivariate logistic regression analysis, a maximum primary tumor diameter > 13.20 cm and MYCN gene amplification were independent risk factors for tumor rupture within highrisk NB.Conclusions: Tumor rupture is an uncommon, life-threatening event for NB patients; these patients are most likely to have poor outcomes due to tumor recurrence or rapid progression. Several treatment modalities, including symptomatic support therapy and chemotherapy, are important for saving lives and for developing NB risk-based treatment in the future.

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“…However, to the best of our knowledge, whether the optimal treatment approach for ruptured HCC after successful TAE is staged hepatic resection or repeated TACE remains under debate. Some groups have argued that TACE should be the first treatment for these patients due to their advanced stage, poor overall prognosis, large tumor volume, impaired liver function, and implantation metastasis (Li et al, 2009;Toshikuni et al, 2011;Shin et al, 2011). However, other studies have reported a survival benefit from staged hepatectomy in these cases (Battula et al, 2009;Miyoshi et al, 2011).…”

Section: Patients With Spontaneously Ruptured Hepatocellular Carcinommentioning

confidence: 99%

Patients with Spontaneously Ruptured Hepatocellular Carcinoma Benefit from Staged Surgical Resection after Successful Transarterial Embolization

Zhang¹,

Zhang²,

Wang³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Surgical resection of spontaneously ruptured hepatocellular carcinoma (HCC) after successful transarterial embolization (TAE) remains controversial. The aim of this study was to investigate its efficacy in a series of cases. Materials and Methods: We retrospectively examined ruptured HCC cases from Jan 2000 to Dec 2008; all of these 126 cases received TAE as the initial therapy. Subsequently, 74 cases received staged surgical resection, and the remaining 52 cases underwent repeated TACE. The baseline demographic data, tumor characteristics, and long term survival were recorded and compared. Results: The demographic and baseline characteristics were comparable between the hepatic resection and TACE groups; furthermore, no significant difference in the tumor characteristics was detected between the two groups. The differences in in-hospital, 30-day and 90-day mortality between the two groups were not significant (P>0.05). However, the 1-, 3-, and 5-year overall survival rates were 85.1%, 63.5%, and 37.8%, respectively, in the hepatic resection group, which were significantly higher than those in the TACE group (69.2%, 46.2%, and 17.3%, respectively, P=0.004). Univariate and multivariate analyses indicated that these patients benefitted from hepatic resection compared with TACE with respect to long-term outcomes. Conclusions: Staged hepatic resection after TAE is an effective treatment that results in superior long-term survival to repeated TACE.

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Outcome and prognostic factors of spontaneous ruptured hepatocellular carcinoma treated with transarterial embolization

Cited by 42 publications

References 30 publications

Prognosis and therapy for ruptured hepatocellular carcinoma: Problems with staging and treatment strategy

Prognosis and therapy for ruptured hepatocellular carcinoma: Problems with staging and treatment strategy

Clinical characteristics and risk factors of 47 cases with ruptured neuroblastoma in children

Patients with Spontaneously Ruptured Hepatocellular Carcinoma Benefit from Staged Surgical Resection after Successful Transarterial Embolization

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