Outcome and toxicity profile after brachytherapy for squamous cell carcinoma of the nasal vestibule

Abstract

Primary brachytherapy for Wang T1 to 2 squamous cell carcinoma of the nasal vestibule offers excellent tumor control rates with acceptable toxicity and preservation of anatomy.

Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas

“…To our knowledge this is the first paper, even if on a small series and with preliminary results, comparing outcomes of BRT and surgery as primary treatment modalities for SCC of the NV. Survival figures were quite similar for the two modalities, consistent with the literature; external beam radiotherapy (EBRT), which is considered a valid alternative option as well, also in combination with BRT, seems to be associated with lower survival rates, but specific studies concerning this matter and comparing the three different modalities (EBRT, BRT, surgery) are lacking. Combination of different treatment modalities should be considered in cases of locally advanced (cT3 according to Wang) lesions and, most of all, clinical and/or pathological evidence of neck metastasis.…”

HDR interventional radiotherapy (brachytherapy) in the treatment of primary and recurrent head and neck malignancies

“…vestibule malignancies have been previously described [25][26][27][28] and extensively discussed in a previous paper by our group, 7 making it a primary site for which HDR IRT offers several specific advantages both under an oncological and a functional point of view. 7,[29][30][31] Such advantages, evidenced also in the present study, starting from very good local control and survival rates, make, according to the authors, IRT the preferred treatment for the primary site in squamous cell carcinomas (SCCs) arising from the nose vestibule. The definite inclusion of such recommendation in the guidelines will anyway require further prospective studies in larger series.…”

“…This group was the largest group in our series and consisted entirely of “midface malignancies.” We define lesions that arose at the junction between mucosal and skin surfaces, typically at the level of the lips, buccal mucosa, and nose vestibule, to be midface malignancies . Peculiarities of nose vestibule malignancies have been previously described and extensively discussed in a previous paper by our group, making it a primary site for which HDR IRT offers several specific advantages both under an oncological and a functional point of view . Such advantages, evidenced also in the present study, starting from very good local control and survival rates, make, according to the authors, IRT the preferred treatment for the primary site in squamous cell carcinomas (SCCs) arising from the nose vestibule.…”

Irradiation of localized squamous cell carcinoma of the nasal vestibule

“…SCC of the nasal vestibule is a very rare disease, with a prevalence of 0.62% in tumors of the head and neck and a yearly incidence rate of <1 per 100,000 people . Most published series are limited by the small number of patients . Since 2002, we have expanded our series to form one of the largest groups so far described in the literature.…”