Outcome following surgery for squamous cell carcinoma of the oesophagus

Abstract

Oesophagectomy following neoadjuvant therapy for SCC of the oesophagus can be performed with low perioperative mortality. A complete response to neoadjuvant therapy was followed by an improved survival outcome.

Salvage cryotherapy after failed radiofrequency ablation for Barrett’s esophagus–related dysplasia is safe and effective

“…Surgery may be associated with significant morbidity and mortality as compared with endoscopic therapy. 13 Endoscopic ablation therapy for BE-related dysplasia can be a cost-effective approach compared with surgical intervention, yielding more quality-adjusted life years at a lower cost. 14 There are limited data regarding the safety and efficacy of cryotherapy in this cohort of patients.…”

Surgical Outcomes Associated with Oesophagectomy in New South Wales: An Investigation of Hospital Volume

“…11,12,14,16,25,27 Operative mortality for single surgeons, multiple surgeons in a single institution and multicentre data report operative mortalities well within acceptable international benchmarks. 26,[28][29][30][31][32][33] In general, operative mortality rates across all institution types in NSW were reassuring particularly given the mortality rates in low-volume hospitals in the USA and UK. 11,16 There may be a number of reasons for this.…”

Oesophageal Squamous Dysplasia

“…Once the lesion has become invasive, endoscopic options are only available until it invades submucosa (T1b), except in certain centres specialised in this treatment. Treatment for invasive oesophageal SCC not amenable to endoscopic management is either oesophagectomy, if comorbidities permit, or definitive chemoradiotherapy [4]. If surgery is feasible, 5-year survival rates with no neoadjuvant treatment are reported as 12-27% [4].…”

“…The diagnosis is predominantly through endoscopic examination of the oesophagus. The overall incidence of oesophageal SCC has been trending downward over the last several decades [3,4]. Western countries, in particular, have lower rates with some South African and Middle Eastern countries experiencing rates exceeding 100 in 100,000 [3].…”

“…Western countries, in particular, have lower rates with some South African and Middle Eastern countries experiencing rates exceeding 100 in 100,000 [3]. Males are diagnosed with SCC in a ratio upwards of eight to one [4]. It represents a significant disease burden, associated with substantial morbidity, quality of life and a poor prognosis.…”