Outcome of Follicular Unit Extraction in Cicatricial Alopecia

Abstract

Background: Cicatricial alopecia is a group of disorders that destroy hair follicles which are replaced with fibrosis, causing permanent hair loss. Cicatricial alopecias are subdivided into two groups "primary" and "secondary". For management of 2ry cases, there are different strategies which differ with the location, size and other scarred area characteristics. These strategies include certain surgical procedures such as excision, flap surgery, use of tissue expansion, and hair transplantation that gained popularity as a permanent method for restoring hair loss. In cicatricial alopecia cases, hair transplant is considered challenging because of the degenerative changes and decreased vascularity of these areas that may produce a lower survival rate of donor hair. Aim of Study:This study aimed to evaluate the role of PRP and nanofat injections together with follicular unit extraction technique in restoration of hair in secondary cicatricial alopecia.Material and Methods: This study was conducted on 30 patients with secondary cicatricial alopecia. Patients were divided into 3 groups, 10 patients in each. Group A: Received PRP with hair transplantation, group B: Received nanofat injections with hair transplantation, while in group C (Control group) patients underwent hair transplantation only.Results: Although adding PRP or nanofat injections with hair transplantation procedure provides an excellent improvement in the texture and quality of the scarred tissues compared to other cases underwent without, there were no significant differences in the clinical outcomes of hair restoration including hair growth density.

Efficacy of Autologous Nano Fat in Hair Transplantation By FUE In Cicatricial Alopecia.

“…In agreement to our study, Tesauro 19 Nevertheless, Ghazal 18 reported that the mean hair growth for group A was 83.76±7.06% after the follow-up period, 84.73±8.4 for group B and 83.70±3.29 for group C with no significant difference between the three groups as regards hair growth and this agreed with our study.…”

“…Furthermore, Ghazal 18 In the present study, there was no statistically significant difference between the studied groups (group A and B) as regard number of hair grafts (Transplanted and Remained after 6 months). Also, that there was no statistically significant difference between the studied groups (group A and B) as regard global photography.…”

“…Yoo 20 showed that both patient and observer satisfaction increased significantly postoperatively. and Ghazal 18 reported that no significant difference be-tween levels of satisfaction among patient in all groups.…”

Evaluation of efficacy of follicular unit extraction versus follicular unit extraction with platelet rich plasma in treatment of cicatricial alopecia

“…20 A similar survival rate was obtained in 37 CA patients with traumatic scars resulted in a 78% survival rate at an average of 13 months of follow-up. 3 Ghazal et al 10 activates mesenchymal cells in dermal papilla and induces transcriptional activity of beta catenin responsible for stem cells differentiation into HF cells. [22][23][24] Mild and transient complications were reported in our study.…”

“…including fractional laser, platelet rich plasma (PRP) and nanofat injections. 9,10 Therefore, the aim of the present study is to evaluate the efficacy of follicular unit extraction versus follicular unit extraction with PRP in treatment of CA.…”