Outcome of Large to Massive Rotator Cuff Tears Repaired With and Without Extracellular Matrix Augmentation: A Prospective Comparative Study

Gilot, Gregory; Alvarez-Pinzon, Andres M.; Barcksdale, Leticia; Westerdahl, David; Krill, Michael K.; Peck, Evan

doi:10.1016/j.arthro.2015.02.032

Cited by 92 publications

(81 citation statements)

References 28 publications

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“…Use of ECM for skeletal muscle regeneration, however, is limited, with only a few published case reports limited to umbilical, perineal, and ventral hernias . In human medicine, ECM materials have been increasingly used to augment repair of large musculotendinous injuries such as rotator cuff injury and Achilles tendinopathy . However, ECM use for muscle regeneration in human patients is similarly limited to only a few case reports and case series .…”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

et al. 2018

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Section: Introductionmentioning

confidence: 99%

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

et al. 2018

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“…6 7 11–13 18–22 25 27 28 33–42 The levels of evidence were II to IV where the majority of studies were level IV retrospective case series. The overall mean CMS was 76.7 (good quality).…”

Section: Resultsmentioning

confidence: 99%

“…The AL group had the most consistent demographics and results, where all six studies used human dermis graft using in part an arthroscopic technique (one study combined with a mini-open technique37 with healing rates ranging from 59.0% to 90.0%) 6 7 25 36 38. Interestingly, human dermal ALs were almost equally distributed between augmentation6 25 36 and bridging7 37 38 indications.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, human dermal ALs were almost equally distributed between augmentation6 25 36 and bridging7 37 38 indications. Similarly, SYs and XEs also had some patients with augmentation and bridging.…”

Section: Discussionmentioning

confidence: 99%

“…Although there are multitude of studies reporting successful clinical outcomes of rotator cuff repair using a number of different grafts,6 12 25 26 the results including tendon healing are diverse and only a few studies have directly compared different materials 11 19. In addition, some authors have reported significant failure and complication rates with poor outcomes when using specific graft materials 21 22 27 28.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Healing rate and clinical outcomes of xenografts appear to be inferior when compared to other graft material in rotator cuff repair: a meta-analysis

Herrera

Woodmass

et al. 2016

Journal of ISAKOS

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A collagen/PLA hybrid scaffold supports tendon‐derived cell growth for tendon repair and regeneration

et al. 2022

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A rotator cuff tendon tear is a common shoulder injury with a relatively high rate of recurrence after surgical repair. In order to reinforce the repair and reduce the risk of clinical complications, a patch scaffold is typically sutured over the tendon tear to provide post‐surgical mechanical support. However, despite considerable research effort in this area, a patch scaffold that provides both superior initial mechanical properties and supports cell proliferation at the same time has not yet been achieved. In this study, we engineered a collagen/poly(lactic acid) (COL/PLA) hybrid yarn to leverage mechanical strength of PLA yarn and the bioactivity of collagen. The COL/PLA yarns were used to fabricate a tissue engineering scaffold using textile weaving technology. This hybrid scaffold had a tensile strength of 354.0 ± 36.0 N under dry conditions and 267.2 ± 15.9 N under wet conditions, which was satisfactory to maintain normal tendon function. By introducing COL yarns into the hybrid scaffold, the proliferation of tendon‐derived cells was significantly improved on the scaffold. Cell coverage after 28‐days of in vitro cell culture was noticeably higher on the COL yarns compared to the PLA yarns as a result of a larger number of cells and more spread cell morphology on collagen. Cells spread in multiple directions on COL yarns, which resembled a more natural cell attachment on extracellular matrix. On the contrary, the cells attached to the PLA filaments presented an elongated morphology along the fiber's axial direction. Combining the mechanical robustness of PLA and the biological activity of collagen, the woven COL/PLA hybrid scaffold has shown its potential to be a promising candidate for tendon repair applications.

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Outcome of Large to Massive Rotator Cuff Tears Repaired With and Without Extracellular Matrix Augmentation: A Prospective Comparative Study

Cited by 92 publications

References 28 publications

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Extracellular matrix scaffolds for treatment of large volume muscle injuries: A review

Healing rate and clinical outcomes of xenografts appear to be inferior when compared to other graft material in rotator cuff repair: a meta-analysis

A collagen/PLA hybrid scaffold supports tendon‐derived cell growth for tendon repair and regeneration

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