Outcome of Ovarian Drilling in Women with Polycystic Ovary Syndrome

Nk, Yanamandra; Gundabattula,

doi:10.7860/jcdr/2015/8001.5586

Cited by 5 publications

(6 citation statements)

References 15 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An additional 15.7% of women conceived with the use of clomiphene citrate, making the total spontaneous PR 62.7%. Results from this study are comparable to Yanamandra and Gundabattula (2015) who reported 24.3% spontaneous pregnancies and additional 37.8% pregnancies after ovulation induction with clomiphene citrate in the 18-month follow-up period, and Felemban et al (2000) who reported 68% PR in the 18-month follow-up period.…”

Section: It Has Been Shown That the Presence Of Subserous Or Intraligamentarysupporting

confidence: 79%

“…Until a few years ago, endoscopic surgical procedures were considered a gold standard for infertility investigation as they are minimally invasive and serve as a diagnostic and therapeutic method at the same time (Yanamandra and Gundabattula, 2015). They can be used as a primary treatment of infertility as well as to enhance outcomes in IVF procedures.…”

Section: Introductionmentioning

confidence: 99%

“…In an IVF programme, the feedback information comes back after 2-3 weeks, whereas after reproductive surgery the time period is measured in months or years in cases where spontaneous conception is expected. Pregnancy rates after reproductive surgery are usually known for groups of patients with particular diagnosis, for example different stages of endometriosis, polycystic ovary syndrome (PCOS) or unexplained infertility (Lee et al, 2013;Shimizu et al, 2011;Yanamandra and Gundabattula, 2015). Taking into account the longer expectation period for feedback information, it is understandable that analyses considering spontaneous PR after reproductive surgery are usually retrospective and include a relatively small number of patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Spontaneous pregnancy rates after reproductive surgery

Frangež

Korošec

Pozlep

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

With the development of IVF procedures, the role of reproductive surgery in the management of infertile couples has been questioned. Pregnancy rates (PR) after IVF procedures are well known, but recent data on spontaneous PR after reproductive surgery are scarce. This study aimed to prospectively evaluate how often fertility is restored by reproductive surgery and to identify which independent factors influence spontaneous pregnancy after reproductive surgery. Eight hundred eighty-eight infertile women who underwent surgery for infertility were prospectively included. Women who were referred to IVF after surgery, ceased to plan pregnancy and were lost to follow-up were excluded. Spontaneous PR was analysed for 519 women. A total of 252 (48.6%) women, including 30 treated with clomiphene citrate, conceived spontaneously in the 12-18 months observation period following surgery. Multivariate logistic regression showed that woman's age (OR 0.95, 95% CI 0.90-0.99) and duration of infertility (OR 0.86, 95% CI 0.74-0.99) significantly influence spontaneous PR. Each year of infertility lowers spontaneous PR following surgery by 14% and each year of woman's age by 5%. The study shows a relatively high percentage of women conceived spontaneously after reproductive surgery. The role of reproductive surgery in the management of infertility should be re-evaluated.

show abstract

Section: It Has Been Shown That the Presence Of Subserous Or Intraligamentarysupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spontaneous pregnancy rates after reproductive surgery

Frangež

Korošec

Pozlep

et al. 2017

Reproductive BioMedicine Online

View full text Add to dashboard Cite

show abstract

“…In a randomized trial comparing metformin and CC, where the primary outcome was live birth rate (LBR), Kar and Sanchita88 reported that the efficacy of metformin was similar to clomiphene in terms of LBR, and their combination gave the highest ovulation rate and LBR. Yanamandra and Gundabattula89 conducted a retrospective study of women who failed ovulation induction for primary infertility and hence underwent diagnostic laparoscopy and hysteroscopy followed by ovarian drilling. They showed an enhanced conception rate (around 50%) with laparoscopic ovarian drilling (LOD).…”

Section: Management Of Pcosmentioning

confidence: 99%

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

Ganie

Vasudevan

Wani

et al. 2019

Indian Journal of Medical Research

163

View full text Add to dashboard Cite

Polycystic ovary syndrome (PCOS) is a common endocrine disorder predominantly affecting women of reproductive age. Clinical manifestations are diverse including hyperandrogenism, anovulation, infertility and increased risk of metabolic diseases besides psychosocial dysfunction. This review provides information on the problem of PCOS in India, its pathophysiology, genetics and an overview of current management options to instigate further research in this field. Prevalence of PCOS in India ranges from 3.7 to 22.5 per cent depending on the population studied and the criteria used for diagnosis. Abnormalities in leptin-adiponectin (adipocyte biology), oxidative stress and autoimmunity are among the mechanisms studied regarding pathogenesis of PCOS. Many candidate gene studies have shown associations with PCOS in various studies. Studies have consistently demonstrated the relationship between the well-known manifestation of hyperandrogenism among Indian PCOS women and the metabolic morbidities including insulin resistance, glucose intolerance and cardiovascular risk. Management of individual components of PCOS can be achieved by medications or surgical methods, though further clarification regarding pathogenesis of PCOS is needed to sharpen our therapeutic armamentarium.

show abstract

“…All ovarian drilling procedures result in reproductive endocrine changes [12,13]. It is not known which of these changes are the result of ovarian drilling and which are related to the surgery per se.…”

Section: Discussionmentioning

confidence: 99%

Primum Non Nocere

Allahbadia

2015

J Obstet Gynecol India

View full text Add to dashboard Cite

Surgical ovarian wedge resection was the first established treatment for women with anovulatory polycystic ovary syndrome (PCOS) but was largely abandoned both due to the risk of postsurgical adhesions and the introduction of medical ovulation induction. Laparoscopic ovarian drilling (LOD) is an alternative method to induce ovulation in PCOS patients with clomiphene citrate resistance instead of gonadotropins. Surgical therapy with LOD may avoid or reduce the need for gonadotropins or may facilitate their use. However, the procedure, though effective, can be traumatic on the ovaries, which may cause postoperative adhesions and/or diminished ovarian reserve. In over-enthusiastic hands, this day-care procedure might lead to iatrogenic premature ovarian failure in young women. Some trials have compared LOD with gonadotropins, but, because of variations in study design and small sample size, the results are inconsistent and definitive conclusions about the relative efficacy of LOD and gonadotropins cannot be extracted from the individual studies. Today, evidence-based reviews conclude that there is no evidence of a significant difference in rates of clinical pregnancy, live birth or miscarriage in women with clomiphene-resistant PCOS undergoing LOD compared to other medical treatments. The reduction in multiple pregnancy rates in women undergoing LOD is the only pro-LOD argument. However, there are ongoing serious concerns about the long-term effects of LOD on ovarian function.

show abstract

Outcome of Ovarian Drilling in Women with Polycystic Ovary Syndrome

Cited by 5 publications

References 15 publications

Spontaneous pregnancy rates after reproductive surgery

Spontaneous pregnancy rates after reproductive surgery

Epidemiology, pathogenesis, genetics & management of polycystic ovary syndrome in India

Primum Non Nocere

Contact Info

Product

Resources

About