2000
DOI: 10.1097/00000658-200003000-00001
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Outcome of Pancreaticoduodenectomy With Pylorus Preservation or With Antrectomy in the Treatment of Chronic Pancreatitis

Abstract: ObjectiveTo compare the short-and long-term results of pancreaticoduodenectomy with pylorus preservation (PPPD) or with antrectomy (Whipple procedure) in the treatment of selected patients with chronic pancreatitis.

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Cited by 220 publications
(158 citation statements)
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“…In this regard, it is noteworthy that reductions in postchallenge glycaemia were observed only in patients undergoing pancreatic-head resections, whereas surgical removal of the pancreatic tail led to deteriorations in glucose control at all time points during the oral glucose tolerance test. This is consistent with previous studies showing a significantly higher incidence of delayed gastric emptying after proximal pancreatectomy than after distal pancreatectomy [14,[29][30][31]. Thus, the delay in gastric emptying observed in some patients after pancreatic-head resection appears to provide a safeguard against the development of postprandial hyperglycaemia.…”
Section: Discussionsupporting
confidence: 92%
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“…In this regard, it is noteworthy that reductions in postchallenge glycaemia were observed only in patients undergoing pancreatic-head resections, whereas surgical removal of the pancreatic tail led to deteriorations in glucose control at all time points during the oral glucose tolerance test. This is consistent with previous studies showing a significantly higher incidence of delayed gastric emptying after proximal pancreatectomy than after distal pancreatectomy [14,[29][30][31]. Thus, the delay in gastric emptying observed in some patients after pancreatic-head resection appears to provide a safeguard against the development of postprandial hyperglycaemia.…”
Section: Discussionsupporting
confidence: 92%
“…Although the patterns of post-challenge glucose excursions after pancreatic-head resection suggest a delay in gastric emptying, this has not been directly assessed in the present study. However, previous studies have provided evidence that gastric emptying is delayed in a significant percentage of patients undergoing pancreaticoduodenectomy with pylorus preservation, whereas the incidence of delayed gastric emptying has been reported to be relatively low in patients treated with a distal pancreatectomy [14,[29][30][31]. Furthermore, while the average extent of pancreatic resection has been estimated as 50% for all the procedures applied in this study, the individual percentage may have varied between 40 and 60%.…”
Section: Discussionmentioning
confidence: 73%
“…Kausch-Whipple PD has evolved to be a safe procedure, especially at high volume centres with mortality rates of less than 3% [30][31][32][33]. Apart from achieving the reasonable short-term pain relief, pancreatic head-related complication can be dealt with simultaneously.…”
Section: Resectional Proceduresmentioning
confidence: 99%
“…The longterm results in CP, however, are poor. Postoperative morbidities range between 30% and 50% [33][34][35][36] with disappointing endocrine and exocrine functions as compared with other resection procedures [16,32,33,[35][36][37][38][39][40]. Thus, PD is no longer a preferred choice in patients with CP.…”
Section: Resectional Proceduresmentioning
confidence: 99%
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