Outcome of patients with stage III or inoperable WT treated on the second United Kingdom WT protocol (UKWT2); A United Kingdom Children's Cancer Study Group (UKCCSG) study

Grundy, Richard G.; Hutton, C. F.; Middleton, Helen; Imeson, John; Pritchard, Jon; Kelsey, Anna; Marsden, H. B.; Vujanić, Gordan; Taylor, Roger

doi:10.1002/pbc.10477

Cited by 32 publications

(15 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because there are no data in literature focusing on the treatment of liver metastases in nephroblastoma and despite the fact that a combination of abdominal radiation and multidrug chemotherapy may achieve a high tumor-control rate [11,12], the aim of surgical radicalism should lead to a reduction of postoperative need for radiation therapy.…”

Section: Discussionmentioning

confidence: 99%

Primary hepatic metastases in nephroblastoma—a report of the SIOP/GPOH Study

Szavay¹,

Luithle²,

Graf³

et al. 2006

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Primary hepatic metastases in nephroblastoma—a report of the SIOP/GPOH Study

Szavay¹,

Luithle²,

Graf³

et al. 2006

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…Albeit, it is important to know the differences in the regimens so as to be able to choose the protocol for the institute. [1215–17]…”

Section: Pros and Consmentioning

confidence: 99%

Management of Wilms′ tumor: NWTS vs SIOP

Bhatnagar

2009

J Indian Assoc Pediatr Surg

View full text Add to dashboard Cite

With the availability of several protocols in the management of Wilms' tumor, there is dilemma in the minds of the treating oncologists or pediatric onco-surgeons as to whether the child should receive upfront chemotherapy or should be operated upon primarily. It is necessary for us to understand why do we follow either of the protocols, NWTS which follows the upfront surgery principle or the SIOP which follows the upfront chemotherapy principle in all stages of the disease. While deciding which protocol to follow, it is imperative to know the pros and cons of the treatment strategies and also to study the outcome patterns in both the treatment regimes which is what this article highlights. In an attempt to compare all the differences in both the major protocols, it was realized that most of our patients in the Indian scenario present with advanced disease and thus poorer outcomes if intensive and appropriate treatment strategies are not utilized. Hence, it is imperative that we should study our own patients through the Indian Wilms' tumor study group and adopt the policies which improve the overall event free survival on a nationwide basis.

show abstract

“…Patients with tumors that the surgeons thought were unresectable were given preoperative chemotherapy [59,60,61]. In patients with stage I, vincristine alone was as effective as vincristine and actinomycin-D.…”

Section: Treatmentmentioning

confidence: 99%

Wilms’ Tumor in Children: An Overview

Varan

2008

Nephron Clin Pract

View full text Add to dashboard Cite

Wilms’ tumor is the most frequently occurring renal tumor in children and is one of the most treatment-responsive tumors. A tumor-suppressor gene and other genetic abnormalities have been implicated in its etiology. In addition, patients with several congenital anomalies, such as Beckwith-Wiedemann syndrome, WAGR syndrome, and Denys-Drash syndrome, have an increased risk of Wilms’ tumor. Previously, a three-drug chemotherapy regimen with surgery and radiotherapy was used with patients in all stages. Now, patients with early-stage Wilms’ tumor are treated with a two-drug regimen without radiotherapy, whereas those in advanced stages still receive the three-drug regimen and radiotherapy. Two large collaborative groups – the National Wilms’ Tumor Study Group (NWTS) in the United States and the International Society of Pediatric Oncology (SIOP) in Europe – are involved in Wilms’ tumor management, which differs in some aspects. Multimodality treatment has been used successfully, and in Europe preoperative strategies are used as well. As the survival rate has now reached 90%, the primary objectives of the physician are to perform nephron-sparing surgery in selected cases and to reduce the dosage and duration of chemotherapy and radiotherapy in appropriate cases. Other renal tumors occur rarely, but have also been treated successfully in the last decade.

show abstract

Outcome of patients with stage III or inoperable WT treated on the second United Kingdom WT protocol (UKWT2); A United Kingdom Children's Cancer Study Group (UKCCSG) study

Cited by 32 publications

References 14 publications

Primary hepatic metastases in nephroblastoma—a report of the SIOP/GPOH Study

Primary hepatic metastases in nephroblastoma—a report of the SIOP/GPOH Study

Management of Wilms′ tumor: NWTS vs SIOP

Wilms’ Tumor in Children: An Overview

Contact Info

Product

Resources

About