Outcome of tuberculous meningitis in children: the first comprehensive retrospective cohort study in Indonesia

Nataprawira, Heda Melinda; Ruslianti, Vindy; Solek, Purboyo; Hawani, Dewi; Milanti, Mia; Anggraeni, Ratna; Memed, F. S.; Kartika, Antonia

doi:10.5588/ijtld.15.0555

Cited by 21 publications

(22 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Data on clinical features and treatment outcomes of childhood TBM from large cohorts of children outside of South Africa are limited ( 11 – 13 ). In settings in Indonesia, a few small studies have reported clinical outcomes of childhood TBM ( 14 – 16 ), but none have explored factors associated with the outcomes. This characterization is clinically relevant, enabling early and targeted interventions to optimize care in this vulnerable population.…”

mentioning

confidence: 99%

Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Nataprawira¹,

Gafar²,

Risan³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

We retrospectively evaluated clinical features and outcomes in children treated for tuberculous meningitis (TBM) at Hasan Sadikin Hospital, Bandung, Indonesia, during 2011–2020. Among 283 patients, 153 (54.1%) were <5 years of age, and 226 (79.9%) had stage II or III TBM. Predictors of in-hospital death (n = 44 [15.5%]) were stage III TBM, hydrocephalus, male sex, low-income parents, seizures at admission, and lack of bacillus Calmette-Guérin vaccination. Predictors of postdischarge death (n = 18 [6.4%]) were hydrocephalus, tuberculoma, and lack of bacillus Calmette-Guérin vaccination. At treatment completion, 91 (32.1%) patients were documented to have survived, of whom 33 (36.3%) had severe neurologic sequelae and 118 (41.7%) had unknown outcomes. Predictors of severe neurologic sequelae were baseline temperature > 38°C, stage III TBM, and baseline motor deficit. Despite treatment, childhood TBM in Indonesia causes substantial neurologic sequelae and death, highlighting the importance of improved early diagnosis, better tuberculosis prevention, and optimized TBM management strategies.

show abstract

mentioning

confidence: 99%

Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Nataprawira¹,

Gafar²,

Risan³

et al. 2022

Emerg. Infect. Dis.

View full text Add to dashboard Cite

show abstract

“…This is likely to be under-identified due to lack of surveillance and a standardised approach to follow-up. Reported outcomes vary depending on prevalence of risk factors including HIV co-infection, drug resistance [93] severe hydrocephalus, cerebral infarct, brainstem dysfunction, raised intracranial pressure and malnutrition [32,33,[94][95][96]. Lack of access to supportive care and neurorehabilitation in low-resourced, TB-endemic settings further exacerbate poor outcomes [97].…”

Section: Discussionmentioning

confidence: 99%

Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability

et al. 2021

View full text Add to dashboard Cite

Tuberculous meningitis disproportionately affects young children. As the most devastating form of tuberculosis, it is associated with unacceptably high rates of mortality and morbidity even if treated. Challenging to diagnose and treat, tuberculous meningitis commonly causes long-term neurodisability in those who do survive. There remains an urgent need for strengthened surveillance, improved rapid diagnostics technology, optimised anti-tuberculosis drug therapy, investigation of new host-directed therapy, and further research on long-term functional and neurodevelopmental outcomes to allow targeted intervention. This review focuses on the neglected field of paediatric tuberculous meningitis and bridges current clinical gaps with research questions to improve outcomes from this crippling disease.

show abstract

“…Hearing loss is found in 7-30% of tubercles meningitis patients. The very high mortality rate is associated with a delay in treatment due to late [9].…”

Section: Discussionmentioning

confidence: 99%

The Disseminated tuberculosis with cavitary lung lesion and tuberculoma in a six-month-old Libyan infant

Dakheel

Najaim²,

Moslah

et al. 2021

J Infect Dev Ctries

View full text Add to dashboard Cite

The patient of the report is a six- month-old Libyan female, who presented with a history of fever, persistent cough, and an attack of seizure. The patient has been diagnosed with a case of brain Tuberculoma and cavitation in the right lung based on the Brain Magnetic resonance imaging and the Chest Computed tomography scan, respectively. Subsequently, the patient was treated with antituberculous drugs and corticosteroids. After finishing the treatment, the patient has been cured. This case illustrates the possibility of developing early disseminated tuberculosis during infancy and highlights the difficulties of the diagnosis during the early stages of the disease. The case emphasizes the benefits of early diagnosis and treatment to prevent severe consequences in infancy.

show abstract

Outcome of tuberculous meningitis in children: the first comprehensive retrospective cohort study in Indonesia

Abstract: TBM causes high mortality and sequelae involving hearing and visual impairment, and neurological and mental development.

Cited by 21 publications

References 0 publications

Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Treatment Outcomes of Childhood Tuberculous Meningitis in a Real-World Retrospective Cohort, Bandung, Indonesia

Tuberculous Meningitis in Children: Reducing the Burden of Death and Disability

The Disseminated tuberculosis with cavitary lung lesion and tuberculoma in a six-month-old Libyan infant

Contact Info

Product

Resources

About