TBM causes high mortality and sequelae involving hearing and visual impairment, and neurological and mental development.
Latar belakang. Perawakan pendek merupakan salah satu indikator kesehatan anak yang dipengaruhi berbagai faktor, salah satunya sosioekonomi. Faktor sosioekonomi di antaranya pendidikan, pekerjaan, penghasilan, jumlah anak kurang dari 5 tahun, dan interval usia dengan anak sebelumnya.Tujuan. Mengetahui hubungan status sosioekonomi dengan perawakan pendek.Metode. Studi potong lintang dilakukan pada anak usia 24–60 bulan yang datang ke Puskesmas Sukajadi dan Tempat Penitipan Anak Bunda Ganesa pada bulan Mei 2018. Sampel dipilih secara proporsional random sampling. Tinggi badan anak diperiksa dan diambil data status sosioekonomi. Analisis statistik menggunakan Chi kuadrat dan analisis multivariat dengan regresi logistik.Hasil. Seratus tiga puluh tiga anak terdiri dari 77 anak dari Puskesmas Sukajadi dan 56 anak dari Bunda Ganesa. Prevalensi perawakan pendek di Puskesmas Sukajadi 40,3%, sedangkan di Bunda Ganesa 16,1%. Tempat penelitian, pendidikan orang tua, berat badan menurut usia, pekerjaan ayah dan pendapatan keluarga memiliki hubungan bermakna dengan perawakan pendek. Analisis multivariat ayah pendidikan menengah dan rendah, serta berat badan menurut usia yang abnormal merupakan risiko perawakan pendek. Sementara anak yang tidak mendapat ASI eksklusif berisiko lebih rendah.Kesimpulan. Prevalensi perawakan pendek lebih besar pada anak dari keluarga sosioekonomi menengah kebawah. Pendidikan ayah dan ibu, berat badan menurut usia, pekerjaan ayah dan pendapatan keluarga memiliki hubungan yang bermakna terhadap perawakan pendek.
AbstrakNeopterin telah diketahui sebagai biomarker untuk diagnostik sepsis neonatorum awitan dini. Hingga saat ini belum diketahui peran neopterin sebagai biomarker untuk memprediksi luaran sepsis neonatorum awitan dini maupun awitan lanjut. Tujuan penelitian ini menentukan neopterin serum sebagai biomarker prediktor sepsis neonatorum awitan dini dan lanjut. Penelitian dilakukan pada bulan Mei-Juli 2017 di RSUP Dr. Hasan Sadikin Bandung. Seluruh neonatus yang memenuhi kriteria sepsis neonatorum, yaitu didapatkan skor Tollner ≥10, dilakukan pemeriksaan neopterin serum menggunakan metode ELISA. Subjek kemudian diikuti dan dikelompokkan menjadi luaran perbaikan dan perburukan. Analisis menggunakan receiver operating characteristic (ROC) untuk mendapatkan luas area under curve, menentukan titik potong serta sensitivitas dan spesifisitas. Subjek penelitian terdiri atas 42 neonatus, mayoritas karakteristik neonatus yang mengalami luaran perburukan berjenis kelamin laki-laki (10 subjek), sepsis awitan dini (11 subjek), cara persalinan dengan operasi (11 subjek), dan tempat persalinan di RS (14 subjek). Temuan kadar neopterin pada luaran perburukan lebih tinggi dibanding dengan luaran perbaikan dan disimpulkan terdapat perbedaan yang bermakna (p<0,01). Kadar neopterin rata-rata yang didapatkan pada sepsis luaran perburukan 60,97 ng/mL dengan rentang kadar 40,63-92,04 ng/mL. Luas area di bawah kurva ROC kadar neopterin adalah 0,981 (95% IK=0,882-1,000; p<0,001). Kadar titik potong neopterin >43,13 dengan sensitivitas 94,1% dan spesifisitas 96,0%. Simpulan, kadar titik potong neopterin adalah 43,13 ng/mL serta memiliki sensitivitas 94,1% dan spesifisitas 96,0%. Biomarker ini dapat menjadi salah satu parameter dalam memprediksi dini luaran perburukan sepsis neonatorum awitan dini dan awitan lanjut. Kata kunci: Luaran, neopterin, sepsis neonatorum Neopterin Serum as Early Predictor of Poor Outcome in Neonatal Sepsis AbstractNeopterin was known as the biomarker for diagnosed early onset neonatal sepsis. Nowadays it has been proven for neopterin as predictors of poor outcome in early and late neonatal sepsis. The objective of this study was to determine serum levels of neopterin as predictors of poor outcome in early and late neonatal sepsis. The study held from May to July 2017 in Dr. Hasan Sadikin General Hospital Bandung. All subjects were neonatal sepsis with Tollner score ≥10 observed for serum levels of neopterin with ELISA method and then followed during hospitalization. The outcome defined as good and poor outcomes. The data were analyzed using receiver operating characteristic (ROC) for getting area under curved, cut-off point and also sensitivity, specificity. Research subjects consisted of 42 neonates, the majority which experienced poor outcomes were male (10 subjects), early onset sepsis (11 subjects), section cesarean procedure (11 subjects) and were born in a hospital (14 subjects). Serum neopterin levels findings significantly correlated with poor outcomes. Mean of poor outcomes in sepsis was 60.97 ng/mL with ...
Purpose In children, chronic kidney disease (CKD) has been known to affect neurocognitive function which can impair the quality of life. This study aims to determine the factors and treatment modalities which might affect neurocognitive function in pediatric population with CKD. Patients and Methods A systematic review was done using 3 electronic databases: PubMed, ScienceDirect, SpringerLink, and carried out based on PRISMA guidelines. Our review included articles published in the last 10 years (2011–2021) in English, on children aged 0–18 years with CKD. Factors affecting the children’s neurocognitive function were assessed. Results Eight articles were included in this study. Three articles reported that parent’s education, especially maternal education affect the neurocognitive function of children with CKD. In relation with modalities, in general, children with CKD who had kidney transplant had a better neurocognitive outcome. A longer duration of hemodialysis (HD) was associated with poorer neurocognitive outcomes. Other factors that can affect the neurocognitive function included depression, a history of abnormal births, seizures, and hypertension. Conclusion In children, CKD might cause neurocognitive function disorders through various complex and interconnected mechanisms. Further studies are needed to determine the mechanism and prevention of neurocognitive disorders, as well as the best choice of therapeutic modality to improve both kidney function and neurocognitive function in children with CKD.
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