Outcome of young adult patients with very-high-risk acute lymphoblastic leukemia treated with pediatric-type chemotherapy – a single institute experience

Cheng, Chao‐Neng; Li, Sin-Syue; Hsu, Ya-Ting; Chen, Yaping; Chen, Tsai-Yun; Chen, Jiann‐Shiuh

doi:10.1016/j.jfma.2021.07.019

Cited by 3 publications

(8 citation statements)

References 38 publications

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“…A total of 168 potentially relevant full-text articles were retrieved for further evaluation. Among these, 26 met the inclusion criteria for our systematic review ( Figure 1 , Table 1 , Supplementary Data ) [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 ]. Fifteen of the included studies (57%) had a prospective design [ 9 , 14 , 16 , 19 , 20 , 22 , 23 , 25 , 26 , 27 , 28 , 29 , 30 , 32 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…Twelve studies comparing the outcomes and/or toxicity of PIR vs. conventional adult-type regimens are summarized in Table 2 [ 10 , 11 , 12 , 15 , 17 , 18 , 21 , 22 , 24 , 29 , 30 , 31 ]. None of the studies were randomized controlled trials.…”

Section: Resultsmentioning

confidence: 99%

“…Five studies had a median follow-up shorter than two years for at least one analyzed group [ 12 , 15 , 17 , 18 , 31 ], and one study did not specify the duration of follow-up [ 21 ]. Additionally, two studies had significantly longer follow-ups for the patients treated with conventional adult protocols [ 12 , 24 ], whereas another had significantly longer follow-ups for the patients treated with PIR [ 15 ]. In most studies, the compared groups had well-matched age distributions.…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen of the included studies (57%) had a prospective design [9,14,16,19,20,22,23,[25][26][27][28][29][30]32,33]. Twelve studies comparing the outcomes and/or toxicity of PIR vs. conventional adult-type regimens are summarized in Table 2 [10][11][12]15,17,18,21,22,24,[29][30][31]. None of the studies were randomized controlled trials.…”

Section: Description Of Studies and Regimensmentioning

confidence: 99%

“…Two studies contain data gathered during two different periods [9,12]. Twelve studies comparing the outcomes and/or toxicity of PIR vs. conventional adult-type regimens are summarized in Table 2 [10][11][12]15,17,18,21,22,24,[29][30][31]. None of the studies were randomized controlled trials.…”

Section: Description Of Studies and Regimensmentioning

confidence: 99%

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Pediatric-Inspired Regimens in the Treatment of Acute Lymphoblastic Leukemia in Adolescents and Young Adults: A Systematic Review

Zeckanovic,

Fuchs,

Heesen

et al. 2023

Current Oncology

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Adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) have significantly worse outcomes than their younger counterparts. Current treatment guidelines rely mostly on non-randomized retrospective studies. We performed a systematic review of studies published within the last 15 years comparing pediatric-inspired regimens (PIR) versus adult-type regimens or performing an age-stratified analysis of outcomes in the AYA population. Due to the heterogeneity of data, a meta-analysis was not possible. However, the gathered data show a trend toward improvement in outcomes and an acceptable toxicity profile in patients treated with PIRs compared to conventional adult-type regimens. There is still room for further improvement, as older patients within the AYA population tend to perform poorly with PIR or conventional adult-type chemotherapy. Further randomized studies are needed to develop an optimal treatment strategy for AYA with ALL.

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