Outcomes and patterns of failure of sarcomatoid carcinoma of the larynx: The Mayo Clinic experience

Gamez, M.E.; Jeans, Elizabeth B.; Hinni, Michael L.; Moore, Eric J.; Young, Geoffrey D.; Ma, Daniel; McGee, L.A.; Buras, Matthew R.; Patel, Samir H.

doi:10.1002/lary.26725

Cited by 10 publications

(21 citation statements)

References 38 publications

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“…The disease had maximum occurrence between the fifth and seventh decades of life and showed an apparent male predominance. It had been noted that alcohol consumption and tobacco use were strong causative agents for the development of squamous carcinoma in general, as well as for SaCa . All these factors were also seen in our study.…”

Section: Discussionsupporting

confidence: 84%

“…However, although clinically suspicious nodes were noted in 15 patients, the true incidence rate of neck node metastasis was only 20%. Possible explanations were the limited reliability of lymph neck node size in predicting cancer metastasis and the exact low node metastasis rate in SaCa . During our follow‐up, only one patient had regional recurrence.…”

Section: Discussionmentioning

confidence: 94%

“…SaCa has now been proven to be biphasic; it usually contains both a sarcomatous spindle cell component and a conventional epithelial squamous cell component. The sarcomatoid as well as conventional squamous carcinoma components have now been proven to arise monoclonally from a single stem cell . The disease is characterized by invasive growth, local recurrence, and poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

“…The disease is characterized by invasive growth, local recurrence, and poor prognosis. The tumor shows morphologic epithelial changes, where areas of squamous and spindle cell differentiation are demonstrated …”

Section: Introductionmentioning

confidence: 99%

“…The sarcomatoid as well as conventional squamous carcinoma components have now been proven to arise monoclonally from a single stem cell. [3][4][5][6][7] The disease is characterized by invasive growth, local recurrence, and poor prognosis. The tumor shows morphologic epithelial changes, where areas of squamous and spindle cell differentiation are demonstrated.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

Niu

2018

The Laryngoscope

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

Niu

2018

The Laryngoscope

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The predictive role of neutrophil-to-lymphocyte ratio in the outcomes of patients with sarcomatoid carcinoma of oral cavity

Pandit

Palwe

Patil

et al. 2021

Eur Arch Otorhinolaryngol

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Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity

Colizza

Gilardi

Greco

et al. 2021

Eur Arch Otorhinolaryngol

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Purpose Carcinosarcoma, also known as Spindle Cell Carcinoma (SpCC), is a rare type of malignant tumor. Generally, this type of pathology occurs in the urogenital tract, the gastrointestinal tract, respiratory tract and mammary gland; in the larynx, SpCC represents only 2–3% of all malignancies. Due to its rarity, there is currently no generally acceptable treatment guideline for this disease. The aim of this study was to systematically review the literature of SpCC of larynx and report epidemiologic, clinicopathologic and main therapeutic approaches for this entity. Methods A systematic literature review was performed using MEDLINE, EMBASE, PubMed and Scopus databases. For this review, the results were extrapolated in the period between January 1990 to September 2020. Data extraction was performed using a standard registry database. The clinical and pathological staging were recalculated according to the Eight Edition of AJCC Cancer Staging Manual and statistical analyses were performed using SPSS Version 25.0. Results A total of 111 patients affected by laryngeal carcinosarcoma were included. From our review arises that surgery is the main treatment for primary laryngeal carcinosarcoma. In this way, various techniques such as minimally invasive laryngoscopy excision, laser CO2 cordectomy, partial laryngectomy (vertical and horizontal) and total laryngectomy. The role of radiotherapy is still controversial. The overall survival (OS) for T1 stage tumor at 5 years of follow-up is 82.9%, the OS for T2 and T3 tumor is 74% and 73.4%. The OS at 5 years of follow-up is 91.7% for supraglottic tumor, 69.3% for glottic tumor and 50% for transglottic site. Subglottic site is described in only 2 cases [12–13], so the OS at 5 years is not statistically significant. The 5-year overall survival in patients without lymph nodes involvement (N0) is 90.2%, 66.7% and 50%, respectively, for N1 and N2 lesions. Conclusion Primary laryngeal carcinosarcoma is a very rare malignancy. There are no clear guidelines in the management but in the literature, surgery is described as the best modality of therapy; radiation only can be a reasonable alternative with controversial efficacy. The most important prognostic factor is the nodal metastasis.

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Outcomes and patterns of failure of sarcomatoid carcinoma of the larynx: The Mayo Clinic experience

Abstract: 4. Laryngoscope, 128:373-377, 2018.

Cited by 10 publications

References 38 publications

Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

Sarcomatoid Carcinoma in the Parotid Gland: A Review of 30 Years of Experience

The predictive role of neutrophil-to-lymphocyte ratio in the outcomes of patients with sarcomatoid carcinoma of oral cavity

Carcinosarcomas of the larynx: systematic review of the literature of a rare nosologic entity

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